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Human LRG1 Protein expressed in Wheat germ - ABIN1309718
Boström, Wu, Jedrychowski, Korde, Ye, Lo, Rasbach, Boström, Choi, Long, Kajimura, Zingaretti, Vind, Tu, Cinti, Højlund, Gygi, Spiegelman: A PGC1-?-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. in Nature 2012
This study shows that TNF-alpha (show TNF Proteins) is the predominant proinflammatory cytokine that induces the secretion of LRG1. LRG1 contributes to angiogenesis-coupled de novo bone formation by increasing angiogenesis and recruiting MSCs in the subchondral bone of osteoarthritis joints.
the expression of 3 miRs and 9 mRNAs associate with the PIK3CA (show PIK3CA Proteins) status. Expression of LRG1 is independent of luminal (A or B) subtype, decreased after neo-adjuvant aromatase (show CYP19A1 Proteins) inhibitor treatment.
Plasma LRG1 predicts both albuminuria and Chronic kidney disease progression beyond traditional risk factors. It may play a role in the pathologic pathway leading to progression of diabetic kidney disease in T2 Diabetes mellitus.
LRG1 may be a key regulatory factor of allergic responses.
Results find serum LRG1 levels are significantly associated with LRG1 expression in gastric tumors. Its inhibition suppresses gastric cancer cell growth and invasion suggesting that LRG1 is implicating in gastric tumorigenesis.
LRG1 plays a crucial role in the proliferation and apoptosis of colorectal cancer (CRC (show CALR Proteins)) by regulating RUNX1 (show RUNX1 Proteins) expression. LRG1 may be a potential detection biomarker as well as a marker for monitoring recurrence and therapeutic target for CRC (show CALR Proteins).
These findings suggest that sputum LRG is a promising biomarker of local inflammation in asthma.
combination of modified whole blood LRG1 mRNA levels, plasma LRG1 protein and Alvarado score at the ED may be useful to diagnose simple and complicated acute appendicitis from other causes of abdominal pain
Downregulation of LRG1 is associated with head and neck squamous cell carcinoma.
Results suggest that serum LRG-1 is a promising biomarker for pancreatic cancer.
Hippocampal LRG overexpression contributes to synaptic dysfunction, which leads to memory impairment with advance of age.
findings reveal a novel and essential role of Lrig1 (show Lrig1 Proteins) in regulating morphogenic events that shape the hippocampal circuits and establish that the assembly of TrkB (show NTRK2 Proteins) with Lrig1 (show Lrig1 Proteins) represents a key mechanism for understanding how specific neuronal populations expand the repertoire of responses to BDNF (show BDNF Proteins) during brain development
Loss of LRG is associated with Lewis lung carcinoma.
Human LRG (hLRG) concentration in the cerebrospinal fluid (CSF (show CSF2 Proteins)) was measured and hLRG expression in post-mortem human cerebral cortex and mouse LRG (mLRG) in the brain were examined.
Mice lacking Lrg1 develop a mild retinal vascular phenotype but exhibit a significant reduction in pathological ocular angiogenesis.
cDNA clones for murine leucine-rich alpha2-glycoprotein were isolated. Expression of LRG during differentiation of 32Dcl3G cells preceded the expression of lactoferrin (show LTF Proteins) and gelatinase but followed myeloperoxidase (show MPO Proteins).
The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002
, leucine-rich alpha-2-glycoprotein 1
, leucine-rich alpha-2-glycoprotein-like
, leucine rich alpha 2 glycoprotein