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Data suggest that primary cells from papillary renal cell carcinoma (show MOK Proteins) secrete the chemokines IL8 (show IL8 Proteins), CXCL16 (show CXCL16 Proteins), and chemerin; these chemokines attract primary human monocytes and induce shift/transdifferentiation in monocytes toward M2 macrophage/foam cell phenotype. (IL8 (show IL8 Proteins) = interleukin-8 (show IL8 Proteins); CXCL16 (show CXCL16 Proteins) = C-X-C motif chemokine (show CCL1 Proteins) ligand 16)
Chemerin-CMKLR1 (show CMKLR1 Proteins) activates Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) and ERK (show EPHB2 Proteins) pathways and facilitates preadipocyte proliferation, adipogenesis, and angiogenesis. Gax (show MEOX2 Proteins) weakens the effect of chemerin on preadipocyte biofunctions.
RARRES2 overexpression in adrenocortical carcinoma cells inhibited Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway activity by promoting beta-catenin (show CTNNB1 Proteins) phosphorylation and degradation, it also inhibited the phosphorylation of p38 mitogen-activated protein kinase (show MAPK14 Proteins). Thus our study identifies RARRES2 as a novel tumor suppressor for adrenocortical carcinoma, which can function through an immune-independent mechanism.
study reveals the tumor-inhibitory effect of chemerin by suppressing inflammatory tumor microenvironment with therapeutic implications for inflammation-associated cancer-like Hepatocellular carcinoma.
Further analysis of chemerin functions in vivo might constitute a crucial step toward optimizing Mesenchymal stromal cells-based therapy for inflammatory diseases.
Stimulation of mesenchymal stromal cells (MSCs) by chemerin increases phosphorylation of p42 (show EPB42 Proteins)/44, p38 (show CRK Proteins) and JNK (show MAPK8 Proteins)-II kinases and inhibitors of these kinases and PKC (show PRRT2 Proteins) reverse chemerin-stimulated MSC (show MSC Proteins) migration.
Elevated chemerin levels in colons from ulcerative colitis patients correlate with disease severity
cathepsin S (show CTSS Proteins) and chemerin only correlated positively with insulin (show INS Proteins) resistance and inflammation
Cathepsin L (show CTSL1 Proteins)- and K-cleaved chemerin trigger robust migration of human blood-derived plasmacytoid dendritic cells ex vivo
Plasma chemerin levels are correlated with obesity, blood pressure, and high-density lipoprotein cholesterol, suggesting that it may play a role in the pathogenesis of metabolic syndrome.
endogenously secreted chemerin plays an autocrine/paracrine role in white adipose tissue, identifying chemerin as a therapeutic target to modulate adipose remodelling.
elevated levels of chemerin were found in colons of mice with experimental colitis, and a neutralizing anti-chemerin antibody improved intestinal inflammation
Data suggest a potential role for chemerin and CMKLR1 (show CMKLR1 Proteins) in the regulation of inflammatory responses in the tumor microenvironment.
Suggest reduction of chemerin could contribute to the antiobesity/antidiabetic properties described for alpha-lipoic acid.
Study indicates that Chemerin plays a role in the negative cross-talk between skeletal muscle and adipose tissue. Specifically, Chemerin promotes the adipogenic differentiation potential and alters the myoblast cell fate from myogenesis to adipogenesis.
Data indicate that chemerin may play an important role in regulating mitochondrial remodelling and function in skeletal muscle.
The chemerin15 (C15) precursor, chemerin, and its receptor, ChemR23, are both upregulated after skin damage and the receptor is expressed by macrophages, neutrophils, and keratinocytes. C15 delivery dampens immediate inflammatory events.
findings reveal previously uncharacterized regulators of chemerin expression in skin and identify a physiologic role for chemerin in skin barrier defense against microbial pathogens.
A novel autocrine/paracrine role for chemerin in regulating osteoclast differentiation of hematopoietic stem cells
this study reports that retinoic acid-activated endothelial cells can promote myeloid and plasmacytoid dendritic cell transmigration across endothelial cell monolayers through the endogenous production of chemerin
Chemerin regulates energy metabolism partly through the Akt and ERK1/2 signaling pathways.
These results suggest that Chemerin promotes lipolysis in mature adipocytes and induces adipogenesis during preadipocyte re-differentiation, further indicating a dual role for Chemerin in the deposition of intramuscular fat in ruminant animals.
chemerin is a novel regulator of lactogenesis via its own receptor in bovine mammary epithelial cells
This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine, and is truncated on both termini from the proprotein.
RAR-responsive protein TIG2
, retinoic acid receptor responder protein 2
, tazarotene-induced gene 2 protein
, CHO functionally unknown type II transmembrane protein
, Tazarotene-induced gene 2 protein