Chemerin Protein (His tag)

Catalog No. ABIN7318984

Product Details

Target: Chemerin (RARRES2) (Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This Chemerin protein is labelled with His tag.

Purpose: Recombinant Human RARRES2/TIG2 Protein (His Tag)

Sequence: Glu21-Ser157

Characteristics: Recombinant Human Retinoic acid receptor responder protein 2 is produced by our Mammalian expression system and the target gene encoding Glu21-Ser157 is expressed with a 6His tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Chemerin (RARRES2) (Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2))

Alternative Name: RARRES2/TIG2 (RARRES2 Products)

Synonyms: HP10433 Protein, TIG2 Protein, 0610007L05Rik Protein, AI303516 Protein, retinoic acid receptor responder 2 Protein, retinoic acid receptor responder (tazarotene induced) 2 Protein, RARRES2 Protein, Rarres2 Protein

Background:

Background: Retinoic acid receptor responder protein 2(RARRES2) is a secreted protein that in humans is encoded by the RARRES2 gene. It is highly expressed in skin, also found in pancreas, liver, spleen, prostate, ovary, small intestine and colon. It is a chemoattractant protein that acts as a ligand for the G protein-coupled receptor CMKLR1. RARRES2 is secreted in an inactive form as prochemerin and is activated through cleavage of the C-terminus by inflammatory and coagulation serine proteases. It is thought to act as a cell surface receptor, found to stimulate chemotaxis of dendritic cells and macrophages to the site of inflammation. RARRES2 is inhibited in psoriatic lesions,it is activated by tazarotene in skin rafts and in the epidermis of psoriatic lesions.

Synonym: Retinoic acid receptor responder protein 2, Chemerin, RAR-responsive protein TIG2, Tazarotene-induced gene 2 protein, RARRES2, TIG2

Molecular Weight: 16.9 kDa

UniProt: Q99969

Pathways: Brown Fat Cell Differentiation