Chemerin Protein (Fc Tag)
-
- Target See all Chemerin (RARRES2) Proteins
- Chemerin (RARRES2) (Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2))
- Protein Type
- Recombinant
-
Origin
- Human
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Chemerin protein is labelled with Fc Tag.
- Purpose
- Recombinant Human RARRES2/TIG2 Protein
- Sequence
- ELTEAQRRGL QVALEEFHKH PPVQWAFQET SVESAVDTPF PAGIFVRLEF KLQQTSCRKR DWKKPECKVR PNGRKRKCLA CIKLGSEDKV LGRLVHCPIE TQVLREAEEH QETQCLRVQR AGEDPHSFYF PGQFAFS
- Specificity
- Glu21-Ser157
- Purity
- > 95 % by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- < 0.01EU/μg
- Top Product
- Discover our top product RARRES2 Protein
-
Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 21-157) protein (His tag)
RARRES2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 17-163) protein (GST tag)RARRES2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 65-163) protein (GST tag)RARRES2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 1-163) protein (GST tag)RARRES2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- Concentration
- 0.8 mg/mL
- Buffer
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
-
- Target
- Chemerin (RARRES2) (Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2))
- Alternative Name
- RARRES2/TIG2 (RARRES2 Products)
- Synonyms
- HP10433 Protein, TIG2 Protein, 0610007L05Rik Protein, AI303516 Protein, retinoic acid receptor responder 2 Protein, retinoic acid receptor responder (tazarotene induced) 2 Protein, RARRES2 Protein, Rarres2 Protein
- Background
-
Description: Retinoic acid receptor responder protein 2 (RARRES2) is a small secreted protein involved in multiple cancers, including adrenocortical carcinoma (ACC). Serum RARRES2 may be used as a novel prognostic marker for ACC. Retinoic acid receptor responder 2 (RARRES2) is transcriptionally downregulated in multiple cancer types. Previous studies suggested that it can serve as an immune-dependent tumor suppressor by acting as a chemoattractant to recruit anticancer immune cells expressing its receptor, the chemerin chemokine receptor 1 (CMKLR1), to sites of tumor. Mechanistically, RARRES2 overexpression in ACC cells inhibited Wnt/beta-catenin pathway activity by promoting beta-catenin phosphorylation and degradation, it also inhibited the phosphorylation of p38 mitogen-activated protein kinase. Thus RARRES2 is a novel tumor suppressor for ACC, which can function through an immune-independent mechanism.
Name: TIG2, HP10433,RARRES2
- Gene ID
- 5919
- UniProt
- Q99969
- Pathways
- Brown Fat Cell Differentiation
-
