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anti-Human APLP1 Antibodies:
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These data reveal a conserved mechanism for the binding of APP (show APP Antibodies)-family proteins to HS and imply a specific regulatory role of HS modifications in the biology of APP (show APP Antibodies) and APP-like (show APP Antibodies) proteins.
APLP1 and APLP2 (show APLP2 Antibodies), behave similarly to APP (show APP Antibodies) in that they both associate with assembled NMDA receptors in the endoplasmic reticulum
CSF (show CSF2 Antibodies) levels of 3 endogenous peptides derived from APLP1 (APL1beta25, APL1beta27 and APL1beta28) were decreased in Down syndrome.
APLP1 has a regulatory role in the nuclear translocation of APP (show APP Antibodies) family intracellular domains due to the sequestration of Fe65 (show APBB1 Antibodies).
[review] APP (show APP Antibodies) and its mammalian homologs, amyloid precursor-like proteins APLP1 and APLP2 (show APLP2 Antibodies), participate under physiological conditions via trans-cellular dimerization in synaptogenesis.
APLP1 binds the II-III loop of the Ca(v)2.3 calcium channel and that this binding promotes internalization of the channel.
Both APLP1 and APLP2 (show APLP2 Antibodies), form transcriptionally active triple protein complexes with Mint3 (show APBA3 Antibodies) and transcriptional co-activators Taz (show TAZ Antibodies) andYap.
Human cerebrospinal fluid contains three APLP1-derived Abeta (show APP Antibodies)-like peptides that are generated by beta- and gamma-cleavages at a concentration of approximately 4.5 nM.
APLP1 and APLP2 (show APLP2 Antibodies) are processed by the gamma-secretase in a Presenilin 1 (show PSEN1 Antibodies)-dependent manner and the extreme carboxyl-terminal fragments produced by this processing (APP-like (show APP Antibodies) Intracellular Domain) are able to enhance Fe65 (show APBB1 Antibodies)-dependent gene activation
APLP1 does not undergo the same type of regulated processing as APP (show APP Antibodies) and APLP2 (show APLP2 Antibodies).
APLP1 exhibits synaptogenic activity, involving trans-synaptic dimerization. APLP1 knock-out mice show impaired basal transmission and a reduced mEPSC frequency.
Results suggest that APLP1 deficiency on its own does not lead to defects in synaptic plasticity, but affects synaptic transmission and network inhibition in the dentate gyrus
[review] A role of APP (show APP Antibodies) and its two closely related homologues APLP1 and APLP2 (show APLP2 Antibodies) has been determined in various aspects of nervous system development and function, in particular, for synapse formation and function.
findings demonstrated that NB-2 (show CNTN5 Antibodies) interacts with APLP and that both NB-2 (show CNTN5 Antibodies) and APLP1 are localized at presynaptic sites, suggesting that NB-2 (show CNTN5 Antibodies) associates with APLP1 in a cis (show CISH Antibodies) manner on the presynaptic membrane
Crystal structure of the E2 domain of amyloid precursor protein-like (show APP Antibodies) protein 1 in complex with sucrose octasulfate.
The 5' UTR (show UTS2R Antibodies) of the Aplp1 gene lacks any type of CAGA (show S100A8 Antibodies) box. This may explain its inability to form amyloid plaques.
Cytoplasmic polyadenylation element (CPE (show CPE Antibodies)) binding factor binds the small intracellular domain (ICD) of APLP1.
The results demonstrated that cell viability and neurite outgrowth of N2a cells undergoing knockdown of Aplp1 were significantly reduced, compared with N2a cells undergoing knockdown of either App (show APP Antibodies) or Aplp2 (show APLP2 Antibodies).
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
amyloid-like protein 1
, amyloid beta (A4) precursor-like protein 1
, amyloid-like protein 1-like
, amyloid precursor-like protein 1