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membrane receptor OxeR1 is involved in StAR protein induction and activation of steroidogenesis triggered by cAMP or angiotensin II, acting, at least in part, through ERK1/2 activation.
OXER1 has a role in regulating the survival-promoting effects of arachidonate 5-lipoxygenase (show ALOX5 Proteins) in prostate cancer cells
identification and cloning of a novel GPCR, R527; 5-oxo-ETE was identified as the ligand for R527; very high level of mRNA expression in eosinophils with high expression also detected in neutrophils and lung macrophages
Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins.
5-oxo-ETE G-protein coupled receptor
, 5-oxo-ETE acid G-protein-coupled receptor 1
, G-protein coupled receptor 170
, G-protein coupled receptor R527
, G-protein coupled receptor TG1019
, oxoeicosanoid receptor 1