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Human NUMA1 ELISA Kit for Sandwich ELISA - ABIN418573
Zhou, Wei, Chen, Dong, Lai, Fang, Jiang, Lu, Zhou, Xie, Luo, Chen: Identification and validation of AIB1 and EIF5A2 for noninvasive detection of bladder cancer in urine samples. in Oncotarget 2016
The function of nuclear mitotic apparatus protein (NuMA) in rDNA transcription and p53 (show TP53 ELISA Kits)-independent nucleolar stress response suggests a central role for NuMA in cellular homeostasis.
Importin-alpha/-beta regulates the NuMA functioning required for assembly of higher-order microtubule structures including the mitotic spindle.
Low post translational modifications of NuMA protein is associated with neoplasms.
Seven NuMA isoforms generated by alternative splicing were categorized into 3 groups: long, middle and short. Both exons 15 and 16 in long NuMA were "hotspot" for alternative splicing. Lower expression of short NuMA was observed in cancer cells compared with nonneoplastic controls.
Chimeric proteins constructed by fusion of LANA of Kaposi's sarcoma-associated herpesvirus with the NuMA could bind with ori-P and enhance replication of an ori-P-containing plasmid.
findings reveal a direct physical link between two important regulators of mitotic progression and demonstrate the critical role of the NuMA-Astrin (show SPAG5 ELISA Kits) interaction for accurate cell division.
Aurora-A (show AURKA ELISA Kits) governs the dynamic exchange between the cytoplasmic and the spindle pole-localized pools of NuMA. Aurora-A (show AURKA ELISA Kits) phosphorylates directly the C terminus of NuMA on three Ser (show SIGLEC1 ELISA Kits) residues, of which Ser1969 determines the dynamic behavior and the spindle orientation functions of NuMA.
Suppressor APC domain containing 2 negatively regulates the localization of LGN (show GPSM2 ELISA Kits) at the cell cortex, likely by competing with NuMA for its binding
NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane.During anaphase correct NuMA localization is mediated by direct membrane phospholipid binding.
Retinoblastoma protein (pRB (show RB1 ELISA Kits)) have a novel function in regulating the mitotic function of NuMA and spindle organization, which are required for proper cell cycle progression.
This study demonstrates that the FGF19 (show FGF19 ELISA Kits)-SHP (show LAMC1 ELISA Kits)-LSD1 (show KDM1A ELISA Kits) axis maintains homeostasis by suppressing unnecessary autophagic breakdown of cellular components, including lipids, under nutrient-rich postprandial conditions.
These results reveal an additional and direct function of NuMA during mitotic spindle positioning, as well as a reiterative use of spindle orientation in the skin to build diverse structures.
a new function for spectrins in the stability of invadosomes and the coupling between actin regulation and ECM (show MMRN1 ELISA Kits) degradation
Calcium plays a role in regulating the expression and function of beta-adducin to sustain normal organization of the spectrin-based cytoskeleton and the differentiation properties in keratinocytes through the calmodulin/EGFR/cadherin signaling pathway.
Loss of 4.1/NuMA interaction results in spindle orientation defects and inhibition of Cdk1 (show CDK1 ELISA Kits) causes increase in cortical NuMA localization
ectopic expression of BRAP2 (show BRAP ELISA Kits) inhibits nuclear localization of HMG20A (show HMG20A ELISA Kits) and NuMA1, and prevents nuclear envelope accumulation of SYNE2 (show SYNE2 ELISA Kits).
organization of a spectrin-like cytoskeleton is associated with keratinocyte differentiation, and cytoskeleton disruption is mediated by either PKCdelta (show PKCd ELISA Kits)(Thr505) phosphorylation associated with phosphorylated adducin or due to reduction of endogenous adducin
Results of this study provide evidence for a role for spectrin in different steps of megakaryocyte development through its participation in the formation of invaginated membranes and in the maintenance of proplatelet structure.
Analysis of 3 new alleles reveals previously unknown consequences of red blood cell (RBC (show CACNA1C ELISA Kits)) spectrin deficiency, resulting in markedly reduced RBC (show CACNA1C ELISA Kits) membrane spectrin content, decreased band 3 (show SLC4A1 ELISA Kits), and absent beta-adducin (show ADD2 ELISA Kits).
The present data indicate that bovine dialyzable leukocyte extract can block the AP-1 (show JUN ELISA Kits) DNA-binding activity and expression of several transcriptions factors in breast cancer cells.
MCAK (show KIF2C ELISA Kits) colocalized with NuMA and XMAP215 (show CKAP5 ELISA Kits) at the center of Ran asters where its activity is regulated by Aurora A (show AURKA ELISA Kits)-dependent phosphorylation of S196, which contributes to proper pole focusing
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
, centrophilin stabilizes mitotic spindle in mitotic cells
, structural nuclear protein
, alpha-spectrin 1, erythroid
, erythroid alpha-spectrin
, hemolytic anemia
, neuroscience mutagenesis facility, 4
, spectrin alpha 1
, spectrin alpha chain, erythrocyte
, spectrin alpha chain, erythrocytic 1
, nuclear mitotic apparatus protein 1
, nuclear mitotic apparatus protein 1-like
, nuclear mitotic apparatus protein 1 S homeolog
, nuclear/mitotic apparatus protein