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anti-Human CDK3 Antibodies:
anti-Mouse (Murine) CDK3 Antibodies:
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These results provided evidence supporting the oncogenic potential of NFAT3 (show NFATC4 Antibodies) and suggested that CDK3-mediated phosphorylation of NFAT3 (show NFATC4 Antibodies) has an important role in skin tumorigenesis.
The analysis of tumor and matched normal lung tissues indicates that miR (show MLXIP Antibodies)-150 downregulation in lung tumors correlates with higher CDK3 levels. In addition, miR (show MLXIP Antibodies)-150 transfection experiments with cancer-derived cell lines reveal that miR (show MLXIP Antibodies)-150-mediated CDK3 suppression directly induces growth inhibition.
High Cdk3-promoted epithelial-mesenchymal transition through activating AP-1 (show FOSB Antibodies) is involved in colorectal cancer metastasis.
Data indicate that microRNA miR (show MLXIP Antibodies)-214 has tumor-suppressive activity in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) through inhibition of E2F2 transcription factor (E2F2 (show E2F2 Antibodies)), cyclin (show PCNA Antibodies)-dependent kinases CDK3 and CDK6 (show CDK6 Antibodies).
Mir (show MLXIP Antibodies)-873 inhibits ESR1 (show ESR1 Antibodies) activity and cell growth via targeting CDK3.
CDK3 is associated with the progression of NPC (show NPC1 Antibodies), and may be a potential biomarker for prediction of the prognosis of patients with NPC (show NPC1 Antibodies).
The Walleye dermal sarcoma virus cyclin (show PCNA Antibodies) functions as a structural ortholog of cyclin C (show CCNC Antibodies) in spite of its limited amino acid sequence identity with C cyclins or with any known cyclins and activates Cdk8 (show CDK8 Antibodies) and Cdk3.
A non-cdk8 (show CDK8 Antibodies)-associated cellular pool of cyclin C (show CCNC Antibodies) combines with cdk3 to stimulate pRb (show RB1 Antibodies) phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently.
Expression level of cdk3 is higher in human cancer cell lines and glioblastoma tissue compared with normal brain tissue. cdk3 phosphorylates activating transcription factor 1 (ATF1 (show AFT1 Antibodies))and enhances the transactivation and transcriptional activities of ATF1 (show AFT1 Antibodies).
Results indicated that CDKL3 (show CDKL3 Antibodies) may be involved in proliferation of cells surrounding the brain ventricle where neuronal progenitor cells are enriched during the late embryo st
CDKL3 (show CDKL3 Antibodies) is involved in neuronal morphogenesis during development.
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0.
cyclin-dependent kinase 3
, cell division protein kinase 3