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Browse our COPS6 Proteins (COPS6)

Full name:
COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis) Proteins (COPS6)
On www.antibodies-online.com are 11 COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis) (COPS6) Proteins from 4 different suppliers available. Additionally we are shipping COPS6 Antibodies (37) and many more products for this protein. A total of 52 COPS6 products are currently listed.
Synonyms:
CG6932, CH6, CSN6, Dch6, Dmel\\CG6932, MOV34-34KD, Sgn3, VIP/MOV34, zgc:112075
list all proteins Gene Name GeneID UniProt
Rat COPS6 COPS6 304343  
COPS6 26893 O88545
COPS6 10980 Q7L5N1

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COPS6 Proteins (COPS6) by Origin

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More Proteins for COPS6 Interaction Partners

Fruit Fly (Drosophila melanogaster) COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis) (COPS6) interaction partners

  1. the 2.5A crystal structure of MPN (show PRSS27 Proteins) domain from Drosophila melanogaster CSN6.

Zebrafish COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis) (COPS6) interaction partners

  1. Findings indicate that cops6 plays an anti-apoptotic role during segmentation.

Mouse (Murine) COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis) (COPS6) interaction partners

  1. results define a mechanism for the regulation of Myc (show MYC Proteins) stability through the CSN-Cullin-Fbxw7 (show FBXW7 Proteins) axis and provide insights into the correlation of CSN6 overexpression with Myc (show MYC Proteins) stabilization/activation during tumorigenesis

  2. loss of CSN6 enhances p53 (show TP53 Proteins)-mediated tumor suppression in vivo and CSN6 plays an important role in regulating DNA damage-associated apoptosis and tumorigenesis through control of the MDM2 (show MDM2 Proteins)-p53 (show TP53 Proteins) signaling pathway

Human COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis) (COPS6) interaction partners

  1. CSN6 positively regulates c-Jun (show JUN Proteins) in a MEKK1 (show MAP3K1 Proteins)-dependent manner

  2. our results indicate that CSN6 is a positive regulator of E6AP (show ube3a Proteins) and is important for cervical cancer development.

  3. CSN6 interacts with p27(Kip1 (show CDKN1B Proteins)) and facilitates ubiquitin-mediated degradation of p27(Kip1 (show CDKN1B Proteins)).

  4. Findings indicate that the deregulation of beta-catenin (show CTNNB1 Proteins) by extracellular signal-regulated kinase 2 (ERK2 (show MAPK1 Proteins))-activated CSN6 protein is important for colorectal cancer (CRC (show CALR Proteins)) development.

  5. Analyses of the pseudo metal-binding motif in CSN6 suggest that the loss of two key histidine residues may contribute to the lack of catalytic activity in CSN6.

  6. Data suggest that CSN6 is an important negative regulator of p57 (Kip2 (show CDKN1C Proteins)) , and that overexpression of CSN6 in many types of cancer could lead to decreased expression of p57 (Kip2 (show CDKN1C Proteins)) and result in promoted cancer cell growth.

  7. COPS6 is a target gene of the BACH1 (show BACH1 Proteins) transcription factor according to ChIP-seq analysis in HEK (show EPHA3 Proteins) 293 cells.

  8. loss of CSN6 enhances p53 (show TP53 Proteins)-mediated tumor suppression in vivo and CSN6 plays an important role in regulating DNA damage-associated apoptosis and tumorigenesis through control of the MDM2 (show MDM2 Proteins)-p53 (show TP53 Proteins) signaling pathway

  9. critical role of caspase 8 (show CASP8 Proteins) in the processing of CSN6.

  10. For the first time our data demonstrate that CSN-mediated deneddylation can be regulated by active Casp3 (show CASP3 Proteins) and that the CSN executes a specific function during the apoptotic process.

COPS6 Protein Profile

Protein Summary

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.

Alternative names and synonyms associated with COPS6

  • COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) (COPS6)
  • COP9 signalosome subunit 6 (Cops6)
  • COP9 complex homolog subunit 6 (CSN6)
  • COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) (cops6)
  • COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana) (Cops6)
  • COP9 signalosome subunit 6 (COPS6)
  • Protein CSN-6 (csn-6)
  • CG6932 protein
  • CH6 protein
  • CSN6 protein
  • Dch6 protein
  • Dmel\\CG6932 protein
  • MOV34-34KD protein
  • Sgn3 protein
  • VIP/MOV34 protein
  • zgc:112075 protein

Protein level used designations for COPS6

COP9 (constitutive photomorphogenic) homolog, subunit 6 , COP9 constitutive photomorphogenic homolog subunit 6 , COP9 signalosome complex subunit 6 , CG6932-PA , CSN6-PA , drosophila COP9 signalosome homolog 6 , COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) , COP9 (constitutive photomorphogenic), subunit 6 , COP9 complex S6 , JAB1-containing signalosome subunit 6 , SGN6 , signalosome subunit 6 , COP9 signalosome subunit 6 , COP9 subunit 6 (MOV34 homolog, 34 kD) , H_NH0506M12.12 , MOV34 homolog, 34 kD , hVIP , vpr-interacting protein

GENE ID SPECIES
479738 Canis lupus familiaris
304343 Rattus norvegicus
42661 Drosophila melanogaster
463587 Pan troglodytes
550465 Danio rerio
26893 Mus musculus
512756 Bos taurus
100125954 Sus scrofa
100171609 Pongo abelii
10980 Homo sapiens
178289 Caenorhabditis elegans
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