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Mouse (Murine) IL6ST Protein expressed in HEK-293 Cells - ABIN2181399
Tanaka, Hara, Copeland, Gilbert, Jenkins, Miyajima: Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit. in Blood 1999
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The expression of IL-6 (show IL6 Proteins), IL-6R and gp130 transcripts were detected very early, increased during the first week of life and were predominantly expressed in the head, epidermis and neuromasts of the anterior and posterior lateral line system.
EBI3 can mediate IL-6 (show IL6 Proteins) trans-signaling in a process that involves gp130 (show LRPPRC Proteins)
data suggest that the different sgp130 forms are released from cells into their immediate surroundings and appear to form cell-associated gradients to modulate their own susceptibility for IL-6 (show IL6 Proteins) trans-signaling.
Blocking IL-6 (show IL6 Proteins) trans-signaling in the CNS abrogates the ability of IL-6 (show IL6 Proteins) to suppress feeding. Furthermore, gp130 (show LRPPRC Proteins) expression is enhanced in the paraventricular nucleus of the hypothalamus (PVH) of obese mice, and deletion of gp130 (show LRPPRC Proteins) in the PVH attenuates the beneficial central IL-6 (show IL6 Proteins) effects on metabolism
C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 (show LRPPRC Proteins) expression following lipoic acid treatment or heat shock.
Results suggest that the protective role of gp130 (show LRPPRC Proteins)-dependent STAT3 (show STAT3 Proteins) activation in experimental colitis involves the expansion and activation of mucosal myeloid-derived suppressor cells.
IL-6 (show IL6 Proteins)/gp130 (show LRPPRC Proteins) signalling in the osteoclast is not essential for normal bone resorption in vivo, but maintains both trabecular and periosteal bone formation in male mice by promoting osteoblast activity through the stimulation of osteoclast-derived coupling factors and osteotransmitters
gp130 (show LRPPRC Proteins)-mediated adipose tissue lipolysis promotes hepatic steatosis and insulin (show INS Proteins) resistance.
differences exist in the expression of receptors utilized by the IL-6 (show IL6 Proteins)/gp130 (show LRPPRC Proteins) family of cytokines in astrocytes and microglia, and (2) the findings provide a molecular basis for the differential response to oncostatin M (show OSM Proteins) by astrocytes versus microglia
Deregulation of gp130 (show LRPPRC Proteins)/STAT3 (show STAT3 Proteins) signalling augments the acute phase reponse and macrophage infiltration during atherosclerosis without impacting on the development of aortic plaques.
Significant differential expression (both increases and decreases) of multiple IL-6 (show IL6 Proteins)/gp130 (show LRPPRC Proteins) cytokines, such as LIF (show LIF Proteins), oncostatin-M (show OSM Proteins), and ciliary neurotrophic factor (show CNTF Proteins), occurred after Muller cell ablation
IL-6sR and gp130 (show ANPEP Proteins), but not IL-6R alpha (show IL6R Proteins), play important roles in regulation of granulosa cell survival
IL-15 alone, similarly to IL-18, has no significant ability for regulation of both soluble IL-6 receptors, sIL-6R and sgp130, released by human neutrophils.
IL-6 signal transducing molecule
interleukin-6 receptor subunit beta
, interleukin 6 signal transducer
, IL-6 receptor subunit beta
, IL-6R subunit beta
, interleukin-6 signal transducer
, membrane glycoprotein 130
, oncostatin-M receptor subunit alpha
, glycoprotein 130