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Browse our anti-Minichromosome Maintenance Complex Component 2 (MCM2) Antibodies

Full name:
anti-Minichromosome Maintenance Complex Component 2 Antibodies (MCM2)
On www.antibodies-online.com are 265 Minichromosome Maintenance Complex Component 2 (MCM2) Antibodies from 28 different suppliers available. Additionally we are shipping Minichromosome Maintenance Complex Component 2 Kits (11) and Minichromosome Maintenance Complex Component 2 Proteins (4) and many more products for this protein. A total of 289 Minichromosome Maintenance Complex Component 2 products are currently listed.
Synonyms:
AA959861, AW476101, BM28, cb737, CCNL1, cdc19, CDCL1, CG7538, chunp6905, D3S3194, dMCM2, Dmel\\CG7538, DmeMCM2, DmMcm2, l(3)rL074, McM2, MCM2-7, MCM2_DROME, MCM7, Mcmd2, MITOTIN, mKIAA0030, PCR3, XMcm2
list all antibodies Gene Name GeneID UniProt
MCM2 4171 P49736
MCM2 312538  
MCM2 17216 P97310

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Top referenced anti-Minichromosome Maintenance Complex Component 2 Antibodies

  1. Human Polyclonal MCM2 Primary Antibody for IHC (p), WB - ABIN653324 : Liaw, Boyd: MCM 2 Expression in Basal Cell Carcinomas and Trichoepitheliomas. in Journal of cutaneous pathology 2009 (PubMed)
    Show all 6 references for ABIN653324

  2. Human Polyclonal MCM2 Primary Antibody for EIA, WB - ABIN401335 : Shukla, Navadgi, Mallikarjuna, Rao: Interaction of hRad51 and hRad52 with MCM complex: a cross-talk between recombination and replication proteins. in Biochemical and biophysical research communications 2005 (PubMed)
    Show all 6 references for ABIN401335

  3. Chicken Monoclonal MCM2 Primary Antibody for IF, IP - ABIN968121 : Cook, Park, Burke, Leone, DeGregori, Engel, Nevins: Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 5 references for ABIN968121

  4. Human Polyclonal MCM2 Primary Antibody for EIA, IHC (p) - ABIN953352 : Im, Ki, Farina, Jung, Hurwitz, Lee: Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. in Proceedings of the National Academy of Sciences of the United States of America 2009 (PubMed)
    Show all 4 references for ABIN953352

  5. Human Monoclonal MCM2 Primary Antibody for FACS, IHC - ABIN969280 : Chuang, Teixeira, Wohlschlegel, Henze, Yates, Méndez, Reed: Phosphorylation of Mcm2 by Cdc7 promotes pre-replication complex assembly during cell-cycle re-entry. in Molecular cell 2009 (PubMed)
    Show all 2 references for ABIN969280

  6. Human Polyclonal MCM2 Primary Antibody for IP, WB - ABIN318931 : Forsburg: Eukaryotic MCM proteins: beyond replication initiation. in Microbiology and molecular biology reviews : MMBR 2004 (PubMed)
    Show all 2 references for ABIN318931

  7. Human Polyclonal MCM2 Primary Antibody for WB - ABIN318933 : Tsuji, Ficarro, Jiang: Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells. in Molecular biology of the cell 2006 (PubMed)
    Show all 2 references for ABIN318933

  8. Human Polyclonal MCM2 Primary Antibody for WB - ABIN2774882 : Yu, Feng, Liang: Pairwise interactions of the six human MCM protein subunits. in Journal of molecular biology 2004 (PubMed)
    Show all 2 references for ABIN2774882

  9. Chicken Polyclonal MCM2 Primary Antibody for WB - ABIN2774881 : Boyd, Shakhtour, Shyr: Minichromosome maintenance protein expression in benign nevi, dysplastic nevi, melanoma, and cutaneous melanoma metastases. in Journal of the American Academy of Dermatology 2008 (PubMed)

More Antibodies against Minichromosome Maintenance Complex Component 2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Minichromosome Maintenance Complex Component 2 (MCM2) interaction partners

  1. Data show the structure of the Cdc45 (show CDC45 Antibodies)/Mcm2-7/Psf1 (show GINS1 Antibodies) GINS (CMG (show CASK Antibodies)) helicase (show DNA2 Antibodies) in the presence of ATPgammaS and a DNA duplex bearing a 3' single-stranded tail.

Zebrafish Minichromosome Maintenance Complex Component 2 (MCM2) interaction partners

  1. the foxn1 (show FOXN1 Antibodies)-mcm2 axis plays a central role in the genetic regulatory network controlling thymus development in zebrafish

Human Minichromosome Maintenance Complex Component 2 (MCM2) interaction partners

  1. PTEN (show PTEN Antibodies) regulates DNA replication through MCM2 and loss of PTEN (show PTEN Antibodies) function leads to replication defects and genomic instability.

  2. MCM2 expression is higher in ovarian and endometrial high-grade serous carcinomas (HGSC) than in ovarian or endometrial endometrioid carcinoma. Knockdown in ovarian HGSC cell line decreased cell proliferation.

  3. quaternary complex of histone H3 (show HIST3H3 Antibodies)-H4 heterodimer with chaperone ASF1 (show SRSF1 Antibodies) and the replicative helicase subunit MCM2

  4. MCM2 is a novel gene responsible for nonsyndromic hearing loss of autosomal dominant inheritance in a Chinese family.

  5. The findings indicated that Mcm-2 could be a useful marker for early detection of oral squamous cell carcinoma

  6. MCM2 may be a novel therapeutic target of lovastatin treatment in NSCLCs.

  7. minichromosome maintenance protein-2 may serve as a useful marker in the screening of cervical carcinoma and precancerous lesions and improve the diagnosis of atypical squamous cell of undetermined significance

  8. Data indicate that minichromosome maintenance protein 2 (MCM2) binding is not required for incorporation of histone H3.1 (show HIST1H3A Antibodies)-H4 into chromatin but is important for stability of H3.1-H4.

  9. The data suggest that MCM2 is not a good biomarker when comparing the different clinical stages of cervical cancer.

  10. Thermodynamic analysis of the quaternary complex together with structural modeling support that ASF1 (show SRSF1 Antibodies) and MCM2 could form a chaperoning module for histones H3 and H4 protecting them from promiscuous interactions.

Xenopus laevis Minichromosome Maintenance Complex Component 2 (MCM2) interaction partners

  1. Data show that MRE11 (show MRE11A Antibodies)- and RAD51-dependent fork repair leading to reloading of the GINS onto the MCM-CDC45 (show CDC45 Antibodies) complex still engaged with the DNA could be sufficient to restore a functional CDC45 (show CDC45 Antibodies)-MCM-GINS (CMG (show CASK Antibodies)) helicase (show DNA2 Antibodies) complex.

  2. Mcm2-7 associate with Cdc45 (show CDC45 Antibodies) and GINS to form a relatively stable CMG (show CASK Antibodies) (Cdc45 (show CDC45 Antibodies)-MCM-GINS) complex.

  3. ATM (show ATM Antibodies) and ATR (show ATR Antibodies) phosphorylate the functionally critical replication protein Mcm2 during both DNA damage and replication checkpoint responses in Xenopus egg extracts

  4. MCM2-7 is the replicative helicase (show DNA2 Antibodies), dispensable for chromatin loading and pre-replicative complex (pre-RC) assembly, but required for origin unwinding during DNA replication

Mouse (Murine) Minichromosome Maintenance Complex Component 2 (MCM2) interaction partners

  1. MCM2 deficiency reduces DNA replication initiation in gene-rich regions of the genome.

  2. these data demonstrate that active MCM2-7 repression is a physiologically important mechanism for RS-induced cell cycle arrest and genome maintenance on an organismal level.

  3. Hematopoietic cells originally express higher levels MCM 2 protein and undergo more frequent apoptosis following doxorubicin-induced DNA-damage in the presence of the FLV envelope protein gp70 (show EMB Antibodies).

  4. Mcm2 deficiency results in short deletions allowing high resolution identification of genes contributing to lymphoblastic lymphoma.

  5. Accumulation and dynamics of Mcm2 are described during oogenesis and the first embryonic cell cycle.

  6. gp70 (show EMB Antibodies) enhances cellular DNA-damage-induced signaling in association with host-specific cellular proteins including acinus (show ACIN1 Antibodies) and MCM2 resulting in the activation of DNA-PK to phosphorylate P53 (show TP53 Antibodies).

Minichromosome Maintenance Complex Component 2 (MCM2) Antigen Profile

Antigen Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.

Alternative names and synonyms associated with Minichromosome Maintenance Complex Component 2 (MCM2)

  • Minichromosome maintenance 2 (Mcm2) antibody
  • minichromosome maintenance complex component 2 (mcm2) antibody
  • MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) (mcm2) antibody
  • minichromosome maintenance complex component 2 (MCM2) antibody
  • minichromosome maintenance complex component 2 (Mcm2) antibody
  • minichromosome maintenance deficient 2 mitotin (S. cerevisiae) (Mcm2) antibody
  • AA959861 antibody
  • AW476101 antibody
  • BM28 antibody
  • cb737 antibody
  • CCNL1 antibody
  • cdc19 antibody
  • CDCL1 antibody
  • CG7538 antibody
  • chunp6905 antibody
  • D3S3194 antibody
  • dMCM2 antibody
  • Dmel\\CG7538 antibody
  • DmeMCM2 antibody
  • DmMcm2 antibody
  • l(3)rL074 antibody
  • McM2 antibody
  • MCM2-7 antibody
  • MCM2_DROME antibody
  • MCM7 antibody
  • Mcmd2 antibody
  • MITOTIN antibody
  • mKIAA0030 antibody
  • PCR3 antibody
  • XMcm2 antibody

Protein level used designations for MCM2

CG7538-PA , Mcm2-PA , minichromosome maintenance 2 , DNA replication licensing factor mcm2 , MCM2 minichromosome maintenance deficient 2, mitotin , minichromosome maintenance protein 2 , DNA replication licensing factor MCM2 , cell devision cycle-like 1 , cyclin-like 1 , minichromosome maintenance deficient 2 (mitotin) , minichromosome maintenance protein 2 homolog , nuclear protein BM28 , minichromosome maintenance deficient 2 mitotin , BM28-homolog , p112 , xMCM2 , minichromosome maintenance complex component 7 , mini chromosome maintenance deficient 2

GENE ID SPECIES
40973 Drosophila melanogaster
448458 Xenopus (Silurana) tropicalis
192338 Danio rerio
4171 Homo sapiens
312538 Rattus norvegicus
380451 Xenopus laevis
416027 Gallus gallus
484622 Canis lupus familiaris
510120 Bos taurus
17216 Mus musculus
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