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Human MCM7 Protein expressed in Wheat germ - ABIN1310563
Henderson, Hall, Prpic, Hessling, Parker, Sampson, Simkins, Brough, Dixon, Lenz, Knapp, Murphy, Taylor, Fischer, Malinowski: The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia. in Journal of immunological methods 2011
Results proved that MCM7 proliferative index is a better method for identifying patients with risk of recurrence in patients surgically resected for meningiomas compared with the traditional methods used in the current clinical practice.
MCM7-cyclin D1 (show CCND1 Proteins) pathway may participate in cancer progression.
The MCM7 directly binds to the centrosomal linker protein (show LAT Proteins) Cep68 in vitro and complexes with Cep68 and VHL (show VHL Proteins) in vivo.
The results clearly demonstrate 7q21-22 amplification, MCM7, and its intronic miR (show MLXIP Proteins)-25 are the major molecular switches involved in the complex oncogenic circuits of gastric cancer.
High MCM7 expression is associated with non-small cell lung cancer.
MCM4 (show MCM4 Proteins) and MCM7 expression is significantly correlated with Ki-67 (show MKI67 Proteins), Bmi1 (show BMI1 Proteins), and cyclin E (show CCNE1 Proteins) expression in esophageal adenocarcinoma, squamous cell carcinoma and precancerous lesions.
Data suggest that interaction of Mcm10 (show MCM10 Proteins) with Mcm2-7 (show MCM2 Proteins) multimer requires Mcm10 (show MCM10 Proteins) domain that contains amino acids 530-655, which overlaps with domain required for stable retention of Mcm10 (show MCM10 Proteins) on chromatin; Mcm10 (show MCM10 Proteins) conserved domain (amino acids 200-482) is essential for DNA replication; both conserved domain and Mcm2-7 (show MCM2 Proteins)-binding domain are required for full activity of Mcm10 (show MCM10 Proteins).
Results show that the expression of MCM7 gene and its microRNA, miR (show MLXIP Proteins)-106b-25 cluster is reduced under hypoxia.
This MCM4 (show MCM4 Proteins) mutation affected human MCM4 (show MCM4 Proteins)/6/7 complex formation, since the complex containing the mutant MCM4 (show MCM4 Proteins) protein is unstable and the mutant MCM4 (show MCM4 Proteins) protein is tend to be degraded.
Authors found that MCM7 highly expressed in K562 cells rather than that in normal neutrophils. Thus, lentivirus-mediated shRNA targeting MCM7 was used to suppress its endogenous expression in K562 cells and develop a novel therapeutic strategy for leukemia.
Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote.
cyclin D1 (show CCND1 Proteins)/CDK4 (show CDK4 Proteins) complexes play a direct role in altering an inhibitory RB.MCM7 complex possibly allowing for setting of the origin in preparation for DNA replication
MCM7 may be a highly informative biomarker for cervical cancer.
Substrate preference and helicase actions of mouse MCM4/6/7 helicase complexes.
Accumulation and dynamics of Mcm7 are described during oogenesis and the first embryonic cell cycle.
cellular DNA replication factor (show CDT1 Proteins) MCM7 is involved in prostate cancer (CaP) and MCM7 gene expression was reduced by green tea catechins
DNA binding and helicase activities of Mcm4 (show MCM4 Proteins)/6/7 are significantly stimulated by Cdt1 (show CDT1 Proteins)
Mcm2-7 (show MCM2 Proteins) associate with Cdc45 (show CDC45 Proteins) and GINS to form a relatively stable CMG (show CASK Proteins) (Cdc45 (show CDC45 Proteins)-MCM-GINS) complex.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
, DNA replication licensing factor MCM7
, homolog of S. cerevisiae Cdc47
, minichromosome maintenance deficient 7
, hypothetical protein
, minichromosome maintenance protein 7
, minichromosome maintenance complex component 7
, minichromosome maintenance protein 2
, MCM7 minichromosome maintenance deficient 7
, minichromosome maintenance complex component 2
, DNA replication licensing factor MCM7-like
, mini chromosome maintenance deficient 7
, CDC47 homolog B
, DNA replication licensing factor mcm7-B
, minichromosome maintenance protein 7-B
, minichromosome maintenance 7
, minichromosome maintenance-PCR1
, CDC47 homolog A
, DNA replication licensing factor mcm7-A
, minichromosome maintenance protein 7-A
, Minichromosome maintenance protein 7