Browse our MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) ELISA Kits

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MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) ELISA Kits (MRE11A)
On www.antibodies-online.com are 4 MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) ELISA Kits from 2 different suppliers available. Additionally we are shipping MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) Antibodies (198) and MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) Proteins (7) and many more products for this protein. A total of 220 MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) products are currently listed.
Synonyms:
ATLD, HNGS1, MRE11, MRE11B, wu:faa63d12, zgc:64018
list all ELISA KIts Gene Name GeneID UniProt
MRE11A 17535 Q61216
MRE11A 4361 P49959
MRE11A 64046 Q9JIM0

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MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) ELISA Kits by Reactivity

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More ELISA Kits for MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) Interaction Partners

Mouse (Murine) MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) interaction partners

  1. cyclin A2 (show CCNA2 ELISA Kits) controlled Mre11 abundance through a C-terminal RNA binding domain that selectively and directly binds Mre11 transcripts to mediate polysome loading and translation.

  2. MRE11 complex influences the elimination of oocytes with unrepaired meiotic double-strand breaks post-natally, in addition to its previously described role in double-strand break repair and homologous synapsis during female meiosis.

  3. Inhibiting MRE11 by mirin during meiotic maturation results in anaphase bridges and also increases the number of gammaH2AX (show H2AFX ELISA Kits) foci in metaphase II. Compromised DNA integrity in mirin-treated oocytes indicates a role for MRE11 in chromosome integrity during meiotic maturation.

  4. The authors demonstrate that ATM (show ATM ELISA Kits) can be activated by DNA double-strand breaks in the absence of the Mre11-Rad50 (show RAD50 ELISA Kits)-NBS1 (show NBN ELISA Kits) (MRN) sensor complex.

  5. TRIP13 (show TRIP13 ELISA Kits)-deficient spermatocytes also progress to an H1t (show HIST1H1T ELISA Kits)-positive stage if ATM (show ATM ELISA Kits) activity is attenuated by hypomorphic mutations in Mre11 or Nbs1 (show NBN ELISA Kits) or by elimination of the ATM (show ATM ELISA Kits)-effector kinase CHK2 (show CHEK2 ELISA Kits)

  6. Impairment of Mre11 complex functions promotes the progression of mammary hyperplasias into invasive and metastatic breast cancers

  7. results suggest that the MRE11-RAD50 (show RAD50 ELISA Kits) complex plays important roles in recognition of dsDNA and initiation of STING-dependent signaling, in addition to its role in DNA-damage responses

  8. The critical role of the MRE11 GAR motif in DSB repair is a mechanistic link between post-translational modifications at the MRE11 GAR motif and DSB processing, as well as the ATR (show ATR ELISA Kits)/CHK1 (show CHEK1 ELISA Kits) checkpoint signaling.

  9. Mre11 is present in mitochondria where it binds to mtDNA and that the amount in mitochondria varies depending on cellular stress and differentiation.

  10. Data show that CS-mediated SCC (show CYP11A1 ELISA Kits) lethality was mitigated in irradiated gain-of-function Rad50 (show RAD50 ELISA Kits)(s/s) mice, and epistasis studies order Rad50 (show RAD50 ELISA Kits) upstream of Mre11.

Human MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) interaction partners

  1. we show that Plk1 (show PLK1 ELISA Kits) phosphorylates Mre11 at S649 during G2 DNA damage recovery and Mre11 phosphorylation at S649/S689 drives premature checkpoint termination and reduced DNA repair

  2. In the absence of RAD51 (show RAD51 ELISA Kits), the unprotected newly replicated genome is degraded by the exonuclease (show EXO1 ELISA Kits) activity of MRE11, and the fragmented nascent DNA accumulates in the cytosol, initiating an innate immune response.

  3. Both the genome instability and cell death of MRE11-null and MRE11-mutated H129N cells are significantly reversed by overexpression of Tdp2 (show TDP2 ELISA Kits), an enzyme that eliminates covalent Top2 (show TOP2A ELISA Kits) conjugates; thus, the essential role of Mre11 nuclease (show DCLRE1C ELISA Kits) activity is likely to remove the DNA lesions.

  4. The results illuminate the important role of Nbs1 (show NBN ELISA Kits) and CtIP (show RBBP8 ELISA Kits) in determining the substrates and consequences of human Mre11/Rad50 (show RAD50 ELISA Kits) nuclease (show DCLRE1C ELISA Kits) activities on protein-DNA lesions.

  5. Cdk-dependent phosphorylation of TRF1 on threonine 371 promotes TRF1 to interact with APBs in S and G2 phases independently of its binding to telomeric DNA. We have demonstrated that the interaction of (pT371)TRF1 with APBs is dependent upon ATM and homologous-recombination-promoting factors such as Mre11 and BRCA1.

  6. Ataxia (show USP14 ELISA Kits)-telangiectasia-like disease (A-TLD (show BMP1 ELISA Kits)) is clinically similar to mild Ataxia (show USP14 ELISA Kits)-telangiectasia and caused by hypomorphic mutations in the MRE11 gene.

  7. although Mre11 is required for efficient HR-dependent repair of ionizing-radiation-induced DSBs, Mre11 is largely dispensable for DSB resection in both chicken DT40 and human TK6 B cell lines.

  8. The aim of this study was to assess the interaction between MRE11 and clinicopathologic variables in breast cancer.

  9. The high expression of MRE11-RAD50 (show RAD50 ELISA Kits)-NBS1 (show NBN ELISA Kits) complex constituents could be a predictor for poor prognosis and chemoresistance in gastric cancer

  10. The expression of DSB repair proteins such as RAD51 (show RAD51 ELISA Kits) and MRE11 was investigated by immunohistochemistry, and associations between RAD51 (show RAD51 ELISA Kits) and MRE11 expression and clinicopathological factors or chemotherapeutic effect were assessed

MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) Antigen Profile

Antigen Summary

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog\; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Alternative names and synonyms associated with MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A)

  • meiotic recombination 11 homolog A (S. cerevisiae) (mre11a) Elisa Kit
  • MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (MRE11A) Elisa Kit
  • meiotic recombination 11 homolog A (S. cerevisiae) (Mre11a) Elisa Kit
  • MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (Mre11a) Elisa Kit
  • ATLD Elisa Kit
  • HNGS1 Elisa Kit
  • MRE11 Elisa Kit
  • MRE11B Elisa Kit
  • wu:faa63d12 Elisa Kit
  • zgc:64018 Elisa Kit

Protein level used designations for MRE11A

meiotic recombination 11 homolog A , MRE11 meiotic recombination 11 homolog A (S. cerevisiae) , MRE11 homolog 1 , MRE11 homolog A , double-strand break repair protein MRE11A , meiotic recombination 11 homolog 1 , mmMRE11A , AT-like disease , DNA recombination and repair protein , endo/exonuclease Mre11 , meiotic recombination 11-like protein

GENE ID SPECIES
406637 Danio rerio
737902 Pan troglodytes
100356946 Oryctolagus cuniculus
17535 Mus musculus
4361 Homo sapiens
64046 Rattus norvegicus
494006 Canis lupus familiaris
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