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Browse our Nkx2-2 Proteins (Nkx2-2)

Full name:
NK2 Homeobox 2 Proteins (Nkx2-2)
On are 7 NK2 Homeobox 2 (Nkx2-2) Proteins from 5 different suppliers available. Additionally we are shipping Nkx2-2 Antibodies (229) and many more products for this protein. A total of 245 Nkx2-2 products are currently listed.
id:ibd5090, nk2.2, Nkx-2.2, nkx2-2, nkx2-2-A, Nkx2.2, NKX2B, tinman, wu:fc83b01, XeNK-2, Xnkx2.2, zgc:136536
list all proteins Gene Name GeneID UniProt
Nkx2-2 4821 O95096
Nkx2-2 18088 P42586
Nkx2-2 366214  

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Nkx2-2 Proteins (Nkx2-2) by Origin

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More Proteins for Nkx2-2 Interaction Partners

Human NK2 Homeobox 2 (Nkx2-2) interaction partners

  1. nuclear import of Nkx2-2 is mediated not only by the classical import pathway but also directly by imp (show IMPA1 Proteins) beta1 or imp 13 (show IPO13 Proteins)

  2. NKX2-2 positivity was defined as moderate-to-strong nuclear immunoreactivity in at least 5% of cells

  3. Our study suggests that CGT (show UGT8 Proteins) expression is controlled by balanced expression of the negative modulator OLIG2 (show OLIG2 Proteins) and positive regulator Nkx2.2, providing new insights into how expression of GalCer is tightly regulated in cell-type- and stage-specific manners.

  4. lentiviral overexpression of transcription factors ASCL1 (show ASCL1 Proteins), SOX10 (show SOX10 Proteins), and NKX2.2 in NPCs was sufficient to induce Sox10 (show SOX10 Proteins) enhancer activity, OPC mRNA, and protein expression consistent with OPC fate

  5. NKX2-2 and MNX1 (show MNX1 Proteins) are etiological genes for neonatal diabetes.

  6. NKX2.2 is a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.

  7. The NKX2-2 can induce desired neuronal lineages from most expressing neural progenitor cells by a mechanism resembling developmental binary cell-fate switching.

  8. NKX2-1 (show NKX2-1 Proteins), NKX2-2, and MEF2C (show MEF2C Proteins) define oncogenic pathways in T cell acute lymphoblastic leukemia (T-ALL).

  9. Functional analysis revealed that NKX2.2 is an EWS (show EWSR1 Proteins)/FLI (show FLII Proteins)-regulated gene that is necessary for oncogenic transformation in Ewing's sarcoma.

  10. EWS (show EWSR1 Proteins)/FLI (show FLII Proteins) mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma

Mouse (Murine) NK2 Homeobox 2 (Nkx2-2) interaction partners

  1. nuclear import of Nkx2-2 is mediated not only by the classical import pathway but also directly by imp (show BRAP Proteins) beta1 or imp 13 (show IPO13 Proteins)

  2. Demonstrate that a rare mature enteroendocrine cell subpopulation that is demarcated by Nkx2.2 expression display stem cell properties during normal intestinal epithelial homeostasis, but is not easily activated upon injury.

  3. that Nkx2.2 and Nkx2.9 proteins play no role in the development of branchiovisceral motor neurons in hindbrain rostral to rhombomere 4.

  4. These data identify Nkx2.2 as key regulator to determine neuronal subtypes in the p3 domain of the central nervous system.

  5. The study demonstrates a previously unrecognized mechanism that controls insulin (show INS Proteins) expression through c-Abl (show ABL1 Proteins)-regulated NKx2.2 and GLUT2 (show SLC2A2 Proteins).

  6. Our studies reveal that a subset of mouse perineurial cells are CNS-derived, express Nkx2.2, and are essential for motor nerve development.

  7. NKX2-2 and MNX1 (show MNX1 Proteins) are etiological genes for neonatal diabetes.

  8. Nato3 (show FERD3L Proteins) induces ectopic Foxa2 (show FOXA2 Proteins)-positive cells and indirectly downregulates Nkx2.2 expression.

  9. Nkx2.2 functions as a major 'switch' to turn off Pdgfra (show PDGFRA Proteins) signaling in oligodendrocyte precursor cells and initiate the intrinsic program for oligodendrocyte differentiation.

  10. Nkx2.2 must repress Neurod1 (show NEUROD1 Proteins) in a Pdx1 (show PDX1 Proteins)+ pancreatic progenitor population to appropriately commit a subset of Neurog3 (show NEUROG3 Proteins)+ endocrine progenitor cells to the alpha cell lineage.

Zebrafish NK2 Homeobox 2 (Nkx2-2) interaction partners

  1. Nkx2.2 promotes timely specification and differentiation of myelinating oligodendrocyte lineage cells from species representing different vertebrate taxa.

  2. Nkx2.2 coordinately activates NeuroD1 with Ngn3 in the endocrine progenitor cell and plays a role in the maintenance of NeuroD1 expression to regulate beta cell function in the mature islet.

Nkx2-2 Protein Profile

Protein Summary

The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.

Alternative names and synonyms associated with Nkx2-2

  • NK2 homeobox 2 (nkx2-2)
  • NK2 homeobox 2 (NKX2-2)
  • NK2 homeobox 2 (Nkx2-2)
  • NK2 transcription factor related 2a (nkx2.2a)
  • id:ibd5090 protein
  • nk2.2 protein
  • Nkx-2.2 protein
  • nkx2-2 protein
  • nkx2-2-A protein
  • Nkx2.2 protein
  • NKX2B protein
  • tinman protein
  • wu:fc83b01 protein
  • XeNK-2 protein
  • Xnkx2.2 protein
  • zgc:136536 protein

Protein level used designations for NK2 Homeobox 2 Proteins (Nkx2-2)

NK2 transcription factor related, locus 2 , homeobox protein XENK-2 , NK-2 homolog B , NK2 transcription factor-like protein B , homeobox protein NK-2 homolog B , homeobox protein Nkx-2.2 , Drosophila NK2 transcription factor related, locus 2 , glycoprotein GP330, renal , homeobox protein Nkx2-2 , homeobox protein NK-2 homolog B-A , homeobox protein Nkx-2.2a

373624 Xenopus laevis
428549 Gallus gallus
4821 Homo sapiens
485744 Canis lupus familiaris
531695 Bos taurus
18088 Mus musculus
366214 Rattus norvegicus
30697 Danio rerio
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