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Data suggest that PINCH1 (show LIMS1 Proteins) and Nck2 critically participate in the regulation of cellular radiosensitivity and EGFR (show EGFR Proteins) function and downstream signaling in a cellular model of human squamous cell carcinoma.
Tir-Intimin interaction recruits the Nck (show NCK1 Proteins) adaptor to a Tir tyrosine phosphorylated residue where it activates neural Wiskott-Aldrich syndrome protein (N-WASP (show WASL Proteins)).
Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics.
NCK2 is involved in the susceptibility to opiates addiction.
The hNck2 SH3 domain also exhibited pH dependent monomer-dimer transition.
Data show that both HK2 (show HK2 Proteins) and NCK2 are expressed in the retinal ganglion cell layer.
Nck2 effectively influences human melanoma phenotype progression.
p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor.
Nck2 is an adaptor protein composed of 3N-SH3 domains followed by a unique Cterminal SH2 domain. It interacts with PINCH (show LIMS1 Proteins) in integrin signal transduction, cell migratio and survival. Review.
biophysical analysis of Nck2 SH3 domain
Inactivation of NCK2 (and NCK1 (show NCK1 Proteins)) inhibits endothelial cell polarity.
These results reveal that Nck (show NCK1 Proteins) regulates preosteoblastic/osteoblastic migration and bone mass.
we show that the non-catalytic region of tyrosine kinase (show NCK1 Proteins) adaptor (NCK (show NCK1 Proteins)) proteins 1 and 2 are distributed in the developing spinal cord
Mouse embryos lacking endothelial Nck1 (show NCK1 Proteins)/2 expression develop extensive angiogenic defects that result in lethality at about embryonic day 10.
Data show that only Nck2 is required for the Slit1 (show SLIT1 Proteins)-induced changes in cortical neuron morphology in vitro.
These results revealed an essential role for HSF4-mediated SKAP2 expression in the regulation of actin reorganization during lens differentiation.
The Cas (show CTNND1 Proteins) utilizes Nck2 to activate Cdc42 (show CDC42 Proteins) and induce cell polarization in response to wound healing.
Nck1 (show NCK1 Proteins) and Nck2 have roles in cell movement and cytoskeletal organization
Nck (show NCK1 Proteins) beta interacts with tyrosine-phosphorylated disabled 1 (show DAB1 Proteins) and redistributes in Reelin (show RELN Proteins)-stimulated neurons
nephrin (show NPHS1 Proteins) selectively binds the Src (show SRC Proteins) homology 2 (SH2)/SH3 domain-containing Nck (show NCK1 Proteins) adaptor proteins, which in turn control the podocyte cytoskeleton in vivo
This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
NCK adaptor protein 2
, cytoplasmic protein NCK2-like
, SH2/SH3 adaptor protein NCK-beta
, cytoplasmic protein NCK2
, growth factor receptor-bound protein 4
, noncatalytic region of tyrosine kinase, beta
, non-catalytic region of tyrosine kinase adaptor protein 2