9530092O11Rik antibody, ADAM-TS5 antibody, ADAMTS1 antibody, ADAMTS11 antibody, AI481094 antibody, ASMP-2 antibody, ADAM-TS 11 antibody, ADAM-TS 5 antibody, ADAMTS-11 antibody, ADAMTS-5 antibody, ADMP-2 antibody, ADAM metallopeptidase with thrombospondin type 1 motif 5 antibody, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) antibody, ADAM metallopeptidase with thrombospondin type 1 motif, 5 antibody, ADAMTS5 antibody, adamts5 antibody, Adamts5 antibody
Background
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis.,ADAMTS5,ADAM-TS 11,ADAM-TS 5,ADAM-TS5,ADAMTS-11,ADAMTS-5,ADAMTS11,ADMP-2,ADAM-TS11,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,ADAM Protein Family,MMPs,Ubiquitin,ADAMTS5