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BAX antibody (AA 84-175)

BAX Reactivity: Human, Mouse, Rat, Pig, Cow, Rabbit, Chicken, Zebrafish (Danio rerio) WB, ELISA, FACS, IP, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN725390
  • Target See all BAX Antibodies
    BAX (BCL2-Associated X Protein (BAX))
    Binding Specificity
    • 40
    • 31
    • 20
    • 18
    • 15
    • 11
    • 11
    • 10
    • 10
    • 9
    • 8
    • 7
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 84-175
    Reactivity
    • 260
    • 156
    • 142
    • 45
    • 30
    • 27
    • 24
    • 17
    • 16
    • 10
    • 9
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Pig, Cow, Rabbit, Chicken, Zebrafish (Danio rerio)
    Host
    • 170
    • 98
    • 4
    • 2
    Rabbit
    Clonality
    • 183
    • 91
    Polyclonal
    Conjugate
    • 141
    • 16
    • 13
    • 13
    • 10
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BAX antibody is un-conjugated
    Application
    • 194
    • 113
    • 71
    • 65
    • 51
    • 51
    • 51
    • 42
    • 41
    • 14
    • 11
    • 8
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Chicken, Cow, Human, Mouse, Pig, Rabbit, Rat, Zebrafish (Danio rerio)
    Predicted Reactivity
    Dog,Cow,Sheep
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Bax
    Isotype
    IgG
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    IP(1-2 μg)
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Zeng, Yi, Huang, An, Wang: "Long-term arsenite exposure induces testicular toxicity by redox imbalance, G2/M cell arrest and apoptosis in mice." in: Toxicology, Vol. 411, pp. 122-132, (2019) (PubMed).

    Si, Zhou, Zhao, Xie, Gan, Zhang, Wang, Zhou, Ren, Zhang: "Effects of ionizing radiation and HLY78 on the zebrafish embryonic developmental toxicity." in: Toxicology, Vol. 411, pp. 143-153, (2019) (PubMed).

    Liu, Li, Yang, Niu, Zhao, Zhao, Wang: "Valproic acid attenuates inflammation of optic nerve and apoptosis of retinal ganglion cells in a rat model of optic neuritis." in: Biomedicine & pharmacotherapy, Vol. 96, pp. 1363-1370, (2018) (PubMed).

    Abdel-Hamid, El-Azab, Moustafa: "Macrolide antibiotics differentially influence human HepG2 cytotoxicity and modulate intrinsic/extrinsic apoptotic pathways in rat hepatocellular carcinoma model." in: Naunyn-Schmiedeberg's archives of pharmacology, Vol. 390, Issue 4, pp. 379-395, (2017) (PubMed).

    Rahman, Ukiana, Uson-Lopez, Sikder, Saito, Kurasaki: "Cytotoxic effects of cadmium and zinc co-exposure in PC12 cells and the underlying mechanism." in: Chemico-biological interactions, Vol. 269, pp. 41-49, (2017) (PubMed).

    Liu, Su, Hao, Chen, Liu, Liao, Li: "Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice." in: International journal of molecular sciences, Vol. 17, Issue 1, (2016) (PubMed).

    Aksu, Özkaraca, Kandemir, Ömür, Eldutar, Küçükler, Çomaklı: "Mitigation of paracetamol-induced reproductive damage by chrysin in male rats via reducing oxidative stress." in: Andrologia, Vol. 48, Issue 10, pp. 1145-1154, (2016) (PubMed).

    Daverey, Agrawal: "Curcumin alleviates oxidative stress and mitochondrial dysfunction in astrocytes." in: Neuroscience, Vol. 333, pp. 92-103, (2016) (PubMed).

    Yang, Lu, Guo: "Platelet-rich plasma protects rat chondrocytes from interleukin-1β-induced apoptosis." in: Molecular medicine reports, Vol. 14, Issue 5, pp. 4075-4082, (2016) (PubMed).

    She, Zhao, Zhu, Han, Xia, Bai, Zhang, Li: "Aluminum Trichloride Disorders Bile Acid Secretion and Induces Hepatocyte Apoptosis in Rats." in: Cell biochemistry and biophysics, (2015) (PubMed).

    Huang, Zou, Shi, Zhang, Peng, Zhang, Gao, Wang, Zhang: "Electroacupuncture stimulates remodeling of extracellular matrix by inhibiting apoptosis in a rabbit model of disc degeneration." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2015, pp. 386012, (2015) (PubMed).

    Li, Zhang, Liu, Ren, Song, Rao, Takahashi, Zhou, Li, Chen: "Deficits of learning and memory in Hemojuvelin knockout mice." in: The Journal of veterinary medical science / the Japanese Society of Veterinary Science, (2015) (PubMed).

    Park, Kim, Choi, Heo, Park: "New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitro." in: Cellular signalling, Vol. 27, Issue 9, pp. 1831-9, (2015) (PubMed).

    He, Han, Hu, Zhang, Hua, Peng: "Canonical Wnt signaling pathway contributes to the proliferation and survival in porcine pancreatic stem cells (PSCs)." in: Cell and tissue research, Vol. 362, Issue 2, pp. 379-88, (2015) (PubMed).

    Han, Ji, Chen, Yin, Xu, Li, Chen, Zhu, Peng: "Protective effects of tao-Hong-si-wu decoction on memory impairment and hippocampal damage in animal model of vascular dementia." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2015, pp. 195835, (2015) (PubMed).

    Mori, Akita, Tanida, Ishida, Toda, Inoue, Yashiro, Sawada, Hirakawa, Nakada et al.: "MUC1 protein induces urokinase-type plasminogen activator (uPA) by forming a complex with NF-κB p65 transcription factor and binding to the uPA promoter, leading to enhanced invasiveness of cancer ..." in: The Journal of biological chemistry, Vol. 289, Issue 51, pp. 35193-204, (2015) (PubMed).

    Peng, Fu, Guo, Zhang, Di, Jiang, Li: "Effects and Mechanism of Baicalin on Apoptosis of Cervical Cancer HeLa Cells I n -v itro." in: Iranian journal of pharmaceutical research : IJPR, Vol. 14, Issue 1, pp. 251-61, (2015) (PubMed).

    He, Song, Liu, Chen, Hua: "Rapamycin inhibits acrolein-induced apoptosis by alleviating ROS-driven mitochondrial dysfunction in male germ cells." in: Cell proliferation, Vol. 47, Issue 2, pp. 161-71, (2014) (PubMed).

    Ye, Li, Li, Yang, Niu, Wang: "Anti-tumor activity and relative mechanism of ethanolic extract of Marsdenia tenacissima (Asclepiadaceae) against human hematologic neoplasm in vitro and in vivo." in: Journal of ethnopharmacology, Vol. 153, Issue 1, pp. 258-67, (2014) (PubMed).

    Lin, Wang, Wang, Fang, Zhang, Yang, Guo, Lin, Zhang, Wang: "Lithocarpus polystachyus REHD leaf aqueous extract inhibits human breast cancer growth in vitro and in vivo." in: Nutrition and cancer, Vol. 66, Issue 4, pp. 613-24, (2014) (PubMed).

  • Target
    BAX (BCL2-Associated X Protein (BAX))
    Alternative Name
    Bax (BAX Products)
    Synonyms
    BAX-ALPHA antibody, bax-A antibody, xBax antibody, xlbax antibody, BAX antibody, bax antibody, fj16e01 antibody, wu:fc50b10 antibody, wu:fj16e01 antibody, BCL2L4 antibody, zgc:112983 antibody, BCL2 associated X, apoptosis regulator antibody, BCL2-associated X protein L homeolog antibody, BCL2-associated X protein antibody, bcl2-associated X protein, a antibody, bcl2-associated X protein, b antibody, BAX antibody, bax.L antibody, bax antibody, baxa antibody, Bax antibody, baxb antibody
    Background

    Synonyms: BCL2L4, Apoptosis regulator BAX, Bcl-2-like protein 4, Bcl2-L-4, BAX

    Background: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

    Gene ID
    581
    UniProt
    Q07812
    Pathways
    p53 Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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