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Nibrin antibody (C-Term)

Name: Nibrin antibody (C-Term)
SKU: ABIN3043282
Price: 370 USD
Availability: InStock

NBN Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated

Western Blotting (WB) image for anti-Nibrin (NBN) (AA 714-745), (C-Term) antibody (ABIN3043282) (Nibrin antibody (C-Term))

Anti-p95 NBS1 Picoband antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue (Nibrin antibody (C-Term))

IHC

IHC analysis of p95 NBS1 using anti-p95 NBS1 antibody . (Nibrin antibody (C-Term))

IHC

5 images

Catalog No. ABIN3043282

Datasheet as PDF

Target See all Nibrin (NBN) Antibodies

Nibrin (NBN)
Binding Specificity
37

15

11

8

7

5

5

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 714-745, C-Term
Reactivity
101

61

35

2

1

1

1

1
Human, Mouse, Rat
Host
120

15
Rabbit
Compatible Secondaries
Clonality
108

27
Polyclonal
Conjugate
69

8

6

6

6

6

6

6

5

3

2

2

2

2

2

2

2
This Nibrin antibody is un-conjugated
Application
106

45

30

27

26

26

25

18

12

11

6

4

2

2

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose

Rabbit IgG polyclonal antibody for Nibrin(NBN) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Sequence

RKNTELEEWL RQEMEVQNQH AKEESLADDL FR

Cross-Reactivity (Details)

No cross reactivity with other proteins.

Characteristics

Rabbit IgG polyclonal antibody for Nibrin(NBN) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: nibrin
Protein Name: Nibrin

Purification

Immunogen affinity purified.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human p95 NBS1 (714-745aa RKNTELEEWLRQEMEVQNQHAKEESLADDLFR), different from the related mouse sequence by three amino acids, and from the related rat sequence by five amino acids.

Isotype

IgG

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anti-Nibrin (NBN) (AA 467-615) antibody
NBN Reactivity: Human WB, ELISA, IHC, FACS, ICC Host: Mouse Monoclonal 7E4C2 unconjugated

anti-Nibrin (NBN) (AA 467-615) antibody
NBN Reactivity: Human, Rat WB, ELISA, IHC, FACS, ICC Host: Mouse Monoclonal 7E4A2 unconjugated

anti-Nibrin (NBN) (AA 461-754) antibody
NBN Reactivity: Human WB, IHC, IHC (p) Host: Mouse Monoclonal 3A2 unconjugated

anti-Nibrin (NBN) (AA 461-754) antibody
NBN Reactivity: Human WB, IHC, IHC (p) Host: Mouse Monoclonal 3A9 unconjugated

anti-Nibrin (NBN) (AA 183-460) antibody
NBN Reactivity: Human WB, IHC, IHC (p) Host: Mouse Monoclonal 8E7 unconjugated

anti-Nibrin (NBN) (AA 183-460) antibody
NBN Reactivity: Human WB, IHC, IHC (p) Host: Mouse Monoclonal 2F5 unconjugated

anti-Nibrin (NBN) (AA 183-460) antibody
NBN Reactivity: Human WB, IHC, IHC (p) Host: Mouse Monoclonal 6E11 unconjugated

anti-Nibrin (NBN) (AA 435-754) antibody
NBN Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated

anti-Nibrin (NBN) (AA 645-754) antibody
NBN Reactivity: Human WB, ELISA Host: Mouse Monoclonal 3E4 unconjugated

anti-Nibrin (NBN) antibody
KO Validated NBN Reactivity: Human WB, IF, ICC, IP Host: Rabbit Polyclonal unconjugated

Application Notes

WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions

For Research Use only
Format

Lyophilized

Reconstitution

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration

500 μg/mL

Buffer

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice

Avoid repeated freezing and thawing.

Storage

4 °C/-20 °C

Storage Comment

At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Target

Nibrin (NBN)

Alternative Name

NBN (NBN Products)

Synonyms

NBN antibody, AT-V1 antibody, AT-V2 antibody, ATV antibody, NBS antibody, NBS1 antibody, P95 antibody, Nbs1 antibody, im:6911679 antibody, zgc:194152 antibody, nibrin antibody, NBN antibody, nbn antibody, Nbn antibody

Background

P95 NBS1, also known as NBN or Nibrin, is a protein which in humans is encoded by the NBN gene. Nibrin is a protein associated with the repair of double strand breaks (DSBs) which pose serious damage to a genome. It is a 754 amino acid protein identified as a member of the NBS1/hMre11/RAD50(N/M/R, more commonly referred to asMRN) double strand DNA break repair complex. This complex recognizes DNA damage and rapidly relocates to DSB sites and forms nuclear foci. It also has a role in regulation of N/M/R (MRN) protein complex activity which includes end-processing of both physiological and mutagenic DNA double strand breaks (DSBs).

Synonyms: AT V1 antibody|AT V2 antibody|ATV antibody|ATV antibody|Cell cycle regulatory protein p95 antibody|FLJ10155 antibody|MGC87362 antibody|NBN antibody|NBN_HUMAN antibody|NBS 1 antibody|NBS antibody|NBS antibody|NBS1 antibody|Nibrin antibody|Nibrin antibody| Nijmegen breakage syndrome 1 (nibrin) antibody|Nijmegen breakage syndrome antibody|Nijmegen breakage syndrome protein 1 antibody|p95 antibody|p95 antibody|p95 protein of the MRE11/RAD50 complex antibody

Gene ID

4683

UniProt

O60934

Pathways

DNA Damage Repair, Production of Molecular Mediator of Immune Response