FRS2 antibody (Center)
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- Target See all FRS2 Antibodies
- FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))
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Binding Specificity
- Center
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FRS2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Characteristics
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Rabbit Polyclonal antibody to FRS2 (fibroblast growth factor receptor substrate 2)
FRS2 antibody - Purification
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the center region of human FRS2. The exact sequence is proprietary.
- Isotype
- IgG
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- Application Notes
- Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*
- Comment
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Positive Control: H1299 , HeLaS3
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
- Preservative
- Thimerosal (Merthiolate)
- Precaution of Use
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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Targeting extracellular and juxtamembrane FGFR2 mutations in chemotherapy-refractory cholangiocarcinoma." in: NPJ precision oncology, Vol. 5, Issue 1, pp. 80, (2021) (PubMed).
: "
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Targeting extracellular and juxtamembrane FGFR2 mutations in chemotherapy-refractory cholangiocarcinoma." in: NPJ precision oncology, Vol. 5, Issue 1, pp. 80, (2021) (PubMed).
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- Target
- FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))
- Alternative Name
- FRS2 (FRS2 Products)
- Synonyms
- frs2 antibody, wu:fd21h10 antibody, zgc:91973 antibody, FRS2A antibody, FRS2alpha antibody, SNT antibody, SNT-1 antibody, SNT1 antibody, 4732458E18 antibody, C330018A15Rik antibody, Frs2alpha antibody, fibroblast growth factor receptor substrate 2 antibody, fibroblast growth factor receptor substrate 2b antibody, FRS2 antibody, frs2b antibody, Frs2 antibody
- Background
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Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Cellular Localization: Endomembrane system - Molecular Weight
- 57 kDa
- Gene ID
- 10818
- Pathways
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Signaling Events mediated by VEGFR1 and VEGFR2
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