PRKAR1A antibody (AA 1-250)
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- Target See all PRKAR1A Antibodies
- PRKAR1A (Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))
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Binding Specificity
- AA 1-250
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PRKAR1A antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Sequence
- MESGSTAASE EARSLRECEL YVQKHNIQAL LKDSIVQLCT ARPERPMAFL REYFERLEKE EAKQIQNLQK AGTRTDSRED EISPPPPNPV VKGRRRRGAI SAEVYTEEDA ASYVRKVIPK DYKTMAALAK AIEKNVLFSH LDDNERSDIF DAMFSVSFIA GETVIQQGDE GDNFYVIDQG ETDVYVNNEW ATSVGEGGSF GELALIYGTP RAATVKAKTN VKLWGIDRDS YRRILMGSTL RKRKMYEEFL
- Cross-Reactivity
- Human, Mouse
- Characteristics
- Polyclonal Antibodies
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human PRKAR1A (NP_002725.1).
- Isotype
- IgG
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- Application Notes
- WB,1:500 - 1:2000,IF,1:50 - 1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid freeze / thaw cycles
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- PRKAR1A (Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))
- Alternative Name
- PRKAR1A (PRKAR1A Products)
- Synonyms
- ACRDYS1 antibody, ADOHR antibody, CAR antibody, CNC antibody, CNC1 antibody, PKR1 antibody, PPNAD1 antibody, PRKAR1 antibody, TSE1 antibody, 1300018C22Rik antibody, RIalpha antibody, Tse-1 antibody, Tse1 antibody, RIIA antibody, prkar1a antibody, zgc:92515 antibody, im:7047729 antibody, cnc1 antibody, pkr1 antibody, ppnad1 antibody, prkar1 antibody, tse1 antibody, protein kinase cAMP-dependent type I regulatory subunit alpha antibody, protein kinase, cAMP dependent regulatory, type I, alpha antibody, protein kinase cAMP-dependent type 1 regulatory subunit alpha antibody, protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a antibody, cAMP-dependent protein kinase type I-alpha regulatory subunit pseudogene antibody, protein kinase cAMP-dependent type I regulatory subunit alpha S homeolog antibody, PRKAR1A antibody, Prkar1a antibody, prkar1aa antibody, LOC707275 antibody, prkar1a.S antibody
- Background
- CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed.,PRKAR1A,ACRDYS1,ADOHR,CAR,CNC,CNC1,PKR1,PPNAD1,PRKAR1,TSE1,Cancer,Signal Transduction,G protein signaling,G2/M DNA Damage Checkpoint,Kinase,Serine/threonine kinases,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Inhibition of Apoptosis,Cytoskeleton,Microtubules,Actins,Hedgehog Signaling Pathway,Endocrine & Metabolism,AMPK Signaling Pathway,Insulin Receptor Signaling Pathway,Immunology & Inflammation,Neuroscience,Neurodegenerative Diseases,Dopamine Signaling in Parkinson's Disease,PRKAR1A
- Molecular Weight
- 38 kDa/42 kDa
- Gene ID
- 5573
- UniProt
- P10644
- Pathways
- Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
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