Browse our VAPB Proteins (VAPB)

Full name:
VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C Proteins (VAPB)
On www.antibodies-online.com are 14 VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C (VAPB) Proteins from 7 different suppliers available. Additionally we are shipping VAPB Antibodies (91) and VAPB Kits (4) and many more products for this protein. A total of 115 VAPB products are currently listed.
Synonyms:
AI225786, AI840687, AI848259, ALS8, D2Abb2e, R75548, VAMP-B, Vamp33b, VAP-B, VAP33b
list all proteins Gene Name GeneID UniProt
VAPB 9217 O95292
Rat VAPB VAPB 60431 Q9Z269
Mouse VAPB VAPB 56491  

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VAPB Proteins (VAPB) by Origin

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Top referenced VAPB Proteins

  1. Human VAPB Protein expressed in Escherichia coli (E. coli) - ABIN2003347 : Choudhary, Kumar, Gnad, Nielsen, Rehman, Walther, Olsen, Mann: Lysine acetylation targets protein complexes and co-regulates major cellular functions. in Science (New York, N.Y.) 2009 (PubMed)
    Show all 4 references for 2003347

  2. Human VAPB Protein expressed in Escherichia coli (E. coli) - ABIN2181890 : Fujimoto, Hamamoto, Taniguchi, Chikahira, Okabe: Molecular epidemiology of adenovirus type 3 detected from 1994 to 2006 in Hyogo Prefecture, Japan. in Japanese journal of infectious diseases 2008 (PubMed)
    Show all 4 references for 2181890

  3. Human VAPB Protein expressed in Escherichia coli (E. coli) - ABIN667277 : Nishimura, Mitne-Neto, Silva, Richieri-Costa, Middleton, Cascio, Kok, Oliveira, Gillingwater, Webb, Skehel, Zatz: A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis. in American journal of human genetics 2004 (PubMed)
    Show all 2 references for 667277

More Proteins for VAPB Interaction Partners

Human VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C (VAPB) interaction partners

  1. ACBD5 (show ACBD5 Proteins)-VAPB interaction regulates peroxisome-endoplasmic reticulum associations. Loss of PO-ER association perturbs PO membrane expansion and increases PO movement.

  2. VAP (show F10 Proteins)-ACBD5 (show ACBD5 Proteins)-mediated contact between the endoplasmic reticulum and peroxisomes mediate organelle maintenance and lipid homeostasis.

  3. Effects of the combined absence of VAPA (show VAPA Proteins) and VAPB in human cells were studied; cells lacking VAP (show F10 Proteins) accumulate high levels of PI4P, actin comets, and trans-Golgi proteins on endosomes. Such defects are mimicked by downregulation of OSBP (show OSBP Proteins), a VAP (show F10 Proteins) interactor and PI4P transporter that participates in VAP (show F10 Proteins)-dependent endoplasmic reticulum-endosomes tethers.

  4. this is the first study to report Amyotrophic lateral sclerosis caused by a VAPB mutation in a Chinese population.

  5. Our work revealed that VAP-A/B knockdown impaired the processing and secretion of PAUF, which is one of the cargo proteins of carriers of the trans-Golgi network to the cell surface.

  6. Heterozygous P56S Vapb knock-in mice show mild age-dependent defects in motor behaviors as characteristic features of the disease. The homozygous P56S Vapb knock-in mice show more severe defects compared with heterozygous mice reflecting the dominant and dose-dependent effects of P56S mutation.

  7. VAPB inhibited the degradation of DeltaF508-CFTR in the ER through interactions with the RMA1-Derlin-BAP31-VCP pathway.

  8. Study characterizes the human VAPB-HCV NS5B interaction and reveals that NS5B C-linker is intrinsically disordered in solution but capable of binding the human VAPB-MSP (show MSMB Proteins) domain which overlaps with those for binding HCV NS5A and human Eph (show EPHA1 Proteins) receptors.

  9. The VAPB and its interacting partners cooperatively regulate protein trafficking through the ERGIC by modulating PtdIns4P levels.

  10. results suggest that the binding of vesicle-associated membrane protein-associated protein B(VAP-B) to Rab3 GTPase activating protein 1(RAB3GAP1 (show RAB3GAP1 Proteins)) is implicated in the regulation of nuclear envelope formation through ER-Golgi intermediate compartment

Mouse (Murine) VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C (VAPB) interaction partners

  1. To identify pathological defects in animals expressing the P56S mutant VAPB protein at physiological levels in the appropriate tissues, we have generated Vapb knock-in mice

  2. The disruption of the IRE1 (show ERN1 Proteins)-XBP1 (show XBP1 Proteins) pathway is a cause for the reduced myotube formation in P56S-VAPB-mutation expressing cells.

  3. Vapb knock-out mice exhibit abnormal muscular triacylglycerol levels and FoxO (show FOXO3 Proteins) target gene transcriptional responses to fasting and refeeding

  4. Mice knocked-out for Vapb showed mild motor deficits after 18 months of age.

  5. VapB positively regulates RANKL (show TNFSF11 Proteins)-mediated osteoclastogenesis via PLCgamma2 (show PLCG2 Proteins)-Ca(2 (show CA2 Proteins)+)-NFAT (show NFATC1 Proteins) signaling

  6. Co-expression of mutant protein-associated protein B (show LEPREL2 Proteins) (VAPB) enhances the transactive response DNA-binding protein (show HSF4 Proteins)-43 (TDP-43 (show TARDBP Proteins))-induced motor neuronal cell death while that of wild type-VAPB attenuates it.

  7. Adeno (show ADORA2A Proteins)-associated viral-mediated over-expression of both wild-type and mutated form of human VAPB selectively induces death of primary motor neurons, albeit with different kinetics.

  8. However, VAPBP56S but not VAPBwt transgenic mice develop cytoplasmic TDP-43 (show TARDBP Proteins) accumulations within spinal cord motor neurons that were first detected at 18 months of age.

  9. The total loss of VAPB function in unfolded protein response, induced by one P56S mutant allele, may contribute to the development of P56SVAPB- induced amyotrophic lateral sclerosis.

VAPB Protein Profile

Protein Summary

The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.

Alternative names and synonyms associated with VAPB

  • vesicle-associated membrane protein-associated protein B/C (Tsp_07972)
  • VAMP (vesicle-associated membrane protein)-associated protein B and C (VAPB)
  • VAMP-associated protein B/C (LOC788595)
  • VAMP-associated protein B/C (LOC100350714)
  • VAMP (vesicle-associated membrane protein)-associated protein B and C (Vapb)
  • vesicle-associated membrane protein, associated protein B and C (Vapb)
  • AI225786 protein
  • AI840687 protein
  • AI848259 protein
  • ALS8 protein
  • D2Abb2e protein
  • R75548 protein
  • VAMP-B protein
  • Vamp33b protein
  • VAP-B protein
  • VAP33b protein

Protein level used designations for VAPB

vesicle-associated membrane protein-associated protein B/C , VAMP (vesicle-associated membrane protein)-associated protein B and C , VAMP-associated protein B/C , VAMP-associated 33 kDa protein , VAMP-B , VAMP-associated protein B , VAP-B , vesicle-associated membrane protein-associated protein B , vesicle-associated membrane protein, associated protein B and C , VAMP-associated protein 33b

GENE ID SPECIES
10906529 Trichinella spiralis
469984 Pan troglodytes
788595 Bos taurus
100350714 Oryctolagus cuniculus
9217 Homo sapiens
419317 Gallus gallus
100144536 Sus scrofa
326580 Bos taurus
60431 Rattus norvegicus
56491 Mus musculus
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