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anti-Human TRIB3 Antibodies:
anti-Mouse (Murine) TRIB3 Antibodies:
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Human Polyclonal TRIB3 Primary Antibody for ICC, IF - ABIN252371
Loewen, Chen, Dudley, Sarthy, Mathura: Genomic response of hypoxic Müller cells involves the very low density lipoprotein receptor as part of an angiogenic network. in Experimental eye research 2009
Show all 3 Pubmed References
study proposes that Trb3 governs left-right (LR) axis patterning as a component of TGF-signaling in embryonic development
TRIB3, a single-domain protein with impaired kinase catalytic activity, has been described to perform a complex of roles, many of which are likely to be cell type-specific. (Review)
High TRB3 (show TAS2R13 Antibodies) expression is associated with basal-like breast cancer.
TRIB3 promotes acute promyelocytic leukemia (show PML Antibodies) progression through stabilization of the oncoprotein PML (show PML Antibodies)-RARalpha (show RARA Antibodies) and inhibition of p53 (show TP53 Antibodies)-mediated senescence.
Downregulation of TRIB3 is associated with lung cancer.
This study aims to investigate whether the Tribbles 3 Q84R polymorphism has profound effects on serum semaphorin 3E (show SEMA3E Antibodies) and what effect semaphorin 3E (show SEMA3E Antibodies) exerts on carotid atherosclerosis.
overexpression of TRIB3 is associated with tumor angiogenesis and a poor prognosis in patients with gastric cancer (GC) . Our findings indicate that TRIB3 is a promising target for antiangiogenic therapy in GC.
Our findings suggest that good glucose and blood pressure control exhibited greater benefits on vascular outcomes in patients with TRIB3 (rs2295490) G allele.
In this exploratory analysis, IRS1 (show IRS1 Antibodies), ENNP1 and TRIB3, known to be associated with type 2 diabetes and harboring genes playing a prominent role in mediating insulin (show INS Antibodies) signaling, may modulate a number of cardiometabolic phenotypes in patients of Italian ancestry with newly-diagnosed type 2 diabetes.
TRIB3 acts as a crucial 'stress adjusting switch' that links homeostasis, metabolic disease and cancer; and is being actively investigated as a disease biomarker and therapeutic target
TRB3 (show TAS2R13 Antibodies) is upregulated in macrophages upon treatment with ox-LDL. TRB3 (show TAS2R13 Antibodies) promotes lipid accumulation and suppresses cytokine expression, suggesting inflammation and foam cell formation can be reciprocally regulated.
TRB3 regulates protein synthesis and breakdown via the Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies)/FoxO (show FOXO3 Antibodies) pathways in skeletal muscle.
Chac1 (show CHAC1 Antibodies) expression is detrimental to arsenite-treated cell survival and TRIB3 is critical for restraining the pro-death potential of Chac1 (show CHAC1 Antibodies) during arsenite stress.
Under physiological conditions, muscle TRIB3 also influences energy expenditure and substrate metabolism, indicating that the decrease and increase in muscle TRIB3 under fasting and nutrient excess, respectively, are critical for metabolic homeostasis.
In a knockout mouse model, Trib3 disruption modestly increased steady-state erythrocyte numbers and decreased mean corpuscular volume.
Palmitate increased TRB3 expression, activated IRE1alpha (show ERN1 Antibodies) signaling, and reduced the insulin (show INS Antibodies)-dependent Akt (show AKT1 Antibodies) phosphorylation. Knocking down TRB3 or IRE1alpha (show ERN1 Antibodies) did not prevent the inhibitory effect of palmitate on Akt (show AKT1 Antibodies) phosphorylation. Results support the idea that ER stress is not responsible for lipid-induced IR in C2C12 myotubes.
These data demonstrate that TRB3 inhibits insulin (show INS Antibodies) signaling in BAT (show BAAT Antibodies), resulting in impaired differentiation and function.
TRB3 is a novel profibrotic mediator in SSc (show CYP11A1 Antibodies). TGF-beta (show TGFB1 Antibodies) induces TRB3, which in turn activates canonical TGF-beta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) signaling and stimulates the release of collagen, creating a positive feedback loop that may contribute to aberrant TGF-beta (show TGFB1 Antibodies) signalling in SSc (show CYP11A1 Antibodies).
study presents the finding that activation of the NF-kappaB (show NFKB1 Antibodies) pathway by Porphyromonas endodontalis LPS (show TLR4 Antibodies) is important for Wnt5a (show WNT5A Antibodies) expression in osteoblasts, and that TRIB3 may modulate the sustained expression of Wnt5a (show WNT5A Antibodies) in osteoblasts stimulated by P. endodontalis
TRIB1 (show TRIB1 Antibodies) and TRIB3 are more strongly expressed than TRIB2 (show TRIB2 Antibodies) in cumulus cells (CC) surrounding oocytes from preovulatory follicles than in CC of immature ones.
This work aimed to study the porcine tribbles homolog 3 (TRIB3) gene and to evaluate its association with meat quality and carcass traits in pigs.
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1.
tribbles homolog 3
, tribbles homolog 3 (Drosophila)
, tribbles homolog 3-like
, neuronal cell death inducible putative kinase
, neuronal cell death-inducible putative kinase
, p65-interacting inhibitor of NF-kappa-B
, p65-interacting inhibitor of NF-kappaB
, induced in fatty liver dystrophy 2
, Neuronal cell death Inducible Putative Kinase
, tribbles 3