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MTA (show CHKA Proteins)1s interacts with CKI-gamma2, which can phosphorylate MTA1s in an antiestrogen-dependen (show CSNK1A1L Proteins)t manner.Estrogen stimulates CKI-gamma2. CKI-gamma2 phosphorylates and modulates the functions of MTA1s.
Data indicate that SNPs rs740423, rs2277737, rs1059684 of CSNK1G2 gene may contribute to familial febrile convulsions in children.
CK1epsilon (show CSNK1E Proteins) and CK1gamma2 were found to bind to Per1 (show PER1 Proteins) and to promote its degradation
Ligand-dependent ubiquitination of Smad3 (show SMAD3 Proteins) is regulated by CK1g2, an inhibitor of TGF-beta (show TGFB1 Proteins) signaling.
These results indicate that CKIgamma2 hyperphosphorylates the serine-repeat motif of CERT (show COL4A3BP Proteins), thereby inactivating CERT (show COL4A3BP Proteins) and down-regulating the synthesis of sphingomyelin.
CKI-gamma2 could further potentiate the ER corepressive function of MTA1s. Kinase dead CK1-gamma2 could not repress estrogen-induced ER transactivation functions.
monomeric protein kinase\; expressed only in testis
casein kinase 1, gamma 2
, casein kinase I isoform gamma-2-like
, CKI-gamma 2
, casein kinase 1 isoform gamma-2
, casein kinase I isoform gamma-2
, casein kinase 1 gamma 2 isoform