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anti-Human GLI2 Antibodies:
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Human Polyclonal GLI2 Primary Antibody for IHC, WB - ABIN2777474
Ikram, Neill, Regl, Eichberger, Frischauf, Aberger, Quinn, Philpott: GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter. in The Journal of investigative dermatology 2004
Show all 24 Pubmed References
Human Polyclonal GLI2 Primary Antibody for ChIP, ELISA - ABIN269891
Won, Kim, Lim, Sung, Kim, Park, Lee, Choi: Autophagy is related to the hedgehog signaling pathway in human gastric adenocarcinoma: prognostic significance of Beclin-1 and Gli2 expression in human gastric adenocarcinoma. in Pathology, research and practice 2015
Show all 3 Pubmed References
Human Polyclonal GLI2 Primary Antibody for ELISA, IHC - ABIN251273
Haycraft, Banizs, Aydin-Son, Zhang, Michaud, Yoder: Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. in PLoS genetics 2005
Human Polyclonal GLI2 Primary Antibody for IHC, WB - ABIN5516755
Enzenhofer, Parzefall, Haymerle, Schneider, Kadletz, Heiduschka, Pammer, Oberndorfer, Wrba, Loader, Grasl, Perisanidis, Erovic: Impact of Sonic Hedgehog Pathway Expression on Outcome in HPV Negative Head and Neck Carcinoma Patients after Surgery and Adjuvant Radiotherapy. in PLoS ONE 2016
Human Polyclonal GLI2 Primary Antibody for ICC, IF - ABIN4314278
Martinez, Kobayashi, Krishnan, Webber, Christie, Guo, Singh, Zochodne: Intrinsic facilitation of adult peripheral nerve regeneration by the Sonic hedgehog morphogen. in Experimental neurology 2015
Human Polyclonal GLI2 Primary Antibody for IHC, ELISA - ABIN1043881
Roessler, Ermilov, Grange, Wang, Grachtchouk, Dlugosz, Muenke: A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2. in Human molecular genetics 2005
GLI2 is a dosage-sensitive gene that may be responsible for the agenesis of corpus callosum observed in the proband.
This inhibitory effect on cell growth was partially rescued by exogenous KRT17 (show KRT17 Antibodies) expression. In the KRT17 (show KRT17 Antibodies)-positive regions in OSCCs, GLI-1 (show GLI1 Antibodies) or GLI-2 was frequently detected, and the number of cells with cleaved caspase-3 (show CASP3 Antibodies) positive was decreased. CONCLUSIONS: KRT17 (show KRT17 Antibodies) promotes tumor cell growth, at least partially, through its anti-apoptotic effect as a result of the KRT17 (show KRT17 Antibodies) overexpression by GLIs in OSCC
Data suggest that Nrp1 (neuropilin-1 (show NRP1 Antibodies)) regulates Hedgehog (show SHH Antibodies) signaling specifically at the level of activation of GLI2 transcriptional activator function; Nrp1 (show NELL1 Antibodies) localization to primary cilium does not correlate with Hedgehog (show SHH Antibodies) signal promotion. These studies were conducted in various cell types.
studies identify a novel molecular mechanism of regulation of CD40L (show CD40LG Antibodies) by the transcription factor GLI2 in the tumor microenvironment downstream of CCR3 (show CCR3 Antibodies) signaling
the data suggest that CCRK (show CDK20 Antibodies) positively regulates the kinetics by which ciliary proteins such as Smoothened (show SMO Antibodies) and Gli2 are imported into the cilium, and that the efficiency of ciliary recruitment allows for potent responses to Hedgehog (show SHH Antibodies) signaling over long time periods.
GLI2 is a regulator of beta-catenin (show CTNNB1 Antibodies) and provides insights into its role in tumorigenesis.
bioinformatics analysis and luciferase reporter assay predicted the direct binding to miR (show MLXIP Antibodies)-125b-5p, which has been reported to function as a tumor suppressor in osteosarcoma. Furthermore, functional experiments validated that cir (show KCNJ5 Antibodies)-GLI2 exerted the tumor-promoting effects on osteosarcoma cells via negatively targeting miR (show MLXIP Antibodies)-125b-5p.
GANT61, which is a targeted inhibitor of Gli1 (show GLI1 Antibodies) and Gli2, decreased cell viability and promoted cell apoptosis. Thus, TGF-b1 induced EMT (show ITK Antibodies) in neuroblastoma (show ARHGEF16 Antibodies) cells to increase their migration. Specifically, EMT (show ITK Antibodies) induced by TGF-b1 in neuroblastoma (show ARHGEF16 Antibodies) cells did not depend on the Smad (show SMAD1 Antibodies) signaling pathway, and the transcription factor Gli (show GLI1 Antibodies) participated in TGF-b1-induced EMT (show ITK Antibodies) independent of Smad (show SMAD1 Antibodies) signaling.
These results demonstrate that miR (show MLXIP Antibodies)-124 is an important downstream target gene of Hh signaling, and the Gli2/miR (show MLXIP Antibodies)-124/AURKA (show AURKA Antibodies) axis is essential for the proliferation and growth of human glioma cells.
in trophoblasts, GLI2 not only directly bound to the promoter region of gene hsd11b2 (show HSD11B2 Antibodies) to transactivate hsd11b2 (show HSD11B2 Antibodies) but also formed a heterodimer with RNA polymerase II, resulting in up-regulation of hsd11b2 (show HSD11B2 Antibodies) gene transcription
Data indicate that the expression levels of transcription factors Gli1 (show GLI1 Antibodies) and Gli2 in muscle were the lowest of the 13 tissues.
The 12 SNPs of GLI2 encompassing exon 4 to exon 8 showed strong association with in the anorectal atresia in pigs.
Gli2 and Gli3 (show GLI3 Antibodies) are dephosphorylated and activated in cilia and that impaired Gli2 and Gli3 (show GLI3 Antibodies) processing in Ta3 (show HSP90B1 Antibodies) mutant is at least in part due to a decrease in Gli2 and Gli3 (show GLI3 Antibodies) phosphorylation.
Sufu (show SUFUH Antibodies) is upregulated in active Shh (show SHH Antibodies) responding tissues and accompanies Gli (show GLI1 Antibodies) activators translocating into and Gli (show GLI1 Antibodies) repressors out of the nucleus.
Gli2+/-;Gli3Delta699/+ mice can serve as a genetic mouse model for common DSD (show FADS1 Antibodies).
Despite increased production of full-length GLI2 and GLI3 (show GLI3 Antibodies) isoforms, previously identified GLI (show GLI1 Antibodies) targets important for mandibular and glossal development (Foxf1 (show FOXF1 Antibodies), Foxf2 (show FOXF2 Antibodies), Foxd1 (show FOXD1 Antibodies) and Foxd2 (show FOXD2 Antibodies)) were transcriptionally downregulated in Kif3a (show KIF3A Antibodies)(f/f);Wnt1 (show WNT1 Antibodies)-Cre embryos.
Gli1 and Gli2 exhibited different functions in the regulation of p63 expression or proliferation of p63(+) cells in Kras-AR driven tumors.
the GLI2 protein level could serve as a feasible marker of ligand-dependent hedgehog (show SHH Antibodies) activation in pancreatic neoplasms.
Study suggested that loss of Gli2 mRNA mediated the anterior-restricted defect in conditional Dicer (show DICER1 Antibodies) knockdown mice and showed that miR (show MLXIP Antibodies)-106b positively regulated Gli2 mRNA expression
Sufu (show SUFUH Antibodies) deletion early in embryogenesis resulted in unstable Gli2 and Gli3 (show GLI3 Antibodies) activity, leading to the ectopic activation of Shh (show SHH Antibodies) signaling.
the three GLI (show GLI1 Antibodies) factors(GLI1 (show GLI1 Antibodies), GLI2, and GLI3 (show GLI3 Antibodies)) in mature hepatocytes form an interactive transcriptional network that is involved in the control of target genes associated with metabolic zonation as well as with lipid and drug metabolism
This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.
GLI-Kruppel family member GLI2
, glioma-associated oncogene family zinc finger 2
, oncogene GLI2
, tax helper protein 1
, tax helper protein 2
, tax-responsive element-2 holding protein
, tax-responsive element-25-bp sequence binding protein
, zinc finger protein GLI2
, Zn finger transcription factor
, zinc finger protein GLI3
, Tax helper protein