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Claudin 4 Proteins (CLDN4)
On www.antibodies-online.com are 7 Claudin 4 (CLDN4) Proteins from 4 different suppliers available. Additionally we are shipping Claudin 4 Antibodies (142) and Claudin 4 Kits (36) and many more products for this protein. A total of 193 Claudin 4 products are currently listed.
Synonyms:
Cep-r, CLDN4, CPE-R, CPER, Cpetr, Cpetr1, hCPE-R, WBSCR8
list all proteins Gene Name GeneID UniProt
CLDN4 1364 O14493
CLDN4 12740 O35054
Rat CLDN4 CLDN4 304407  

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Claudin 4 Proteins (CLDN4) by Origin

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Human Claudin 4 (CLDN4) interaction partners

  1. Claudin-4 functionally contributes to both ovarian tumor cell apoptosis resistance and migration and targeting extracellular loop interactions of claudin-4 may have therapeutic implications for reducing ovarian tumor burden.

  2. Fluorescence-based flow cytometry and xenon magnetic resonance imaging (MRI (show C7ORF49 Proteins)) indicate binding of the biosensor specifically to claudin 4 (Cldn4)-expressing cells.

  3. Studies indicate that Grainyhead-like transcription factor 2 (show HNF1B Proteins) (GRHL2 (show GRHL2 Proteins)) controls the expression of E-cadherin (CDH1 (show CDH1 Proteins)) required for adherens junctions and possibly regulates the expression of claudin-4 (CLDN4) in tight junctions.

  4. Studies indicate claudin 1 (CLDN-1 (show CLDN1 Proteins)) as a target for improving epidermal drug absorption and preventing HCV infection and of claudin 4 (CLDN-4) as a target for anticancer therapeutics.

  5. Mislocalization claudin-3 (show CLDN3 Proteins) to nucleus in colon cancer and mislocalization claudin-4 to nucleus in adenomas of the colon were detected for the first time. The potential reasons for the paradoxical expression are discussed and a review of the literature, related all the alleged mechanisms of this mislocalization is provided.

  6. Reg (show EXTL3 Proteins) I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4.

  7. claudin-4 may represent different mechanisms of lymphatic vessel invasion with both biomarkers is related to poor prognosis

  8. These results suggested that increase of Cldn4-expression may be involved in early molecular events during carcinogenesis of adenocarcinoma, whereas increase of Cldn7 (show CLDN7 Proteins)-expression may be associated with tumor invasion or progression.

  9. that claudin-4 can be helpful at least in making a reliable differential diagnosis of spiradenoma when overlapping morphologic features do not allow to further subclassification in the overwhelming variety of the adnexal tumors.

  10. Results showed overexpression of CLDN4 in endometrial cancer cells. Its intracellular presence coupled with the biphasic effects of E2 on its expression in the cytoskeleton suggest that it may be involved in cell signaling to and from tight junctions.

Mouse (Murine) Claudin 4 (CLDN4) interaction partners

  1. Reg (show KCNH2 Proteins) I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4.

  2. a Grhl2 (show GRHL2 Proteins)/Ovol2 (show OVOL2 Proteins) network controls Cldn4 and Rab25 (show RAB25 Proteins) expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia

  3. Data show that claudin-4 and claudin-7 (show CLDN7 Proteins) were observed in hepatocytes of severely damaged mouse and human livers.

  4. The claudin-4-mediated chloride conductance can be regulated endogenously by a protease-channel-activating protease 1 (cap1 (show PRSS8 Proteins)).

  5. Claudin 4 has little effect on normal lung physiology but may function to protect against acute lung injury in mice.

  6. The results suggest that progressive hydronephrosis in Cldn4(-/-) mice arises from urinary tract obstruction due to urothelial hyperplasia, and that Cld4 plays an important role in maintaining the homeostatic integrity of normal urothelium.

  7. the results indicate that Grhl2 (show GRHL2 Proteins) regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 (show CLDN3 Proteins) and Cldn4, as well as of Rab25 (show RAB25 Proteins), which increases the Cldn4 protein and its localization at TJs

  8. Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3 (show CLDN3 Proteins)/-4 protein suggests structural modifications of the toxin to target specific claudins

  9. Claudin-3 (show CLDN3 Proteins) in the apical-most regions maintains the impermeable tight junctions during lactation, and claudin-4 contributes

  10. Claudin-4 overexpression is associated with epigenetic derepression in gastric carcinoma.

Pig (Porcine) Claudin 4 (CLDN4) interaction partners

  1. Tumor necrosis factor-alpha (show TNF Proteins) increases claudin-1 (show CLDN1 Proteins), 4, and 7 expression in renal tubular cells, altering permeability and transepithelial electrical resistance.

  2. Claudin-4 expression shows age-dependent change in cellular localization on pig jejunal villous epithelial cells

  3. These findings indicate that claudin-4 and -7 may play a role in the gingiva junctional epithelium even in the absence of tight junctions.

Claudin 4 (CLDN4) Protein Profile

Protein Summary

This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.

Alternative names and synonyms associated with Claudin 4 (CLDN4)

  • claudin 4 (CLDN4)
  • claudin-4-like (LOC100059948)
  • claudin 4 (cldn4)
  • claudin 4 (Cldn4)
  • claudin 4-like (LOC100340963)
  • claudin-4-like (LOC100856416)
  • RIKEN cDNA 4930412D23 gene (4930412D23Rik)
  • similar to claudin 4 (LOC688420)
  • Cep-r protein
  • CLDN4 protein
  • CPE-R protein
  • CPER protein
  • Cpetr protein
  • Cpetr1 protein
  • hCPE-R protein
  • WBSCR8 protein

Protein level used designations for Claudin 4 Proteins (CLDN4)

claudin-4 , claudin 4 , CPE-receptor , Clostridium perfringens enterotoxin receptor 1 , Williams-Beuren syndrome chromosomal region 8 protein , CPE-R , clostridium perfringens enterotoxin receptor , tight junction-associated protein , uncharacterized protein LOC73934

GENE ID SPECIES
780477 Ovis aries
100059948 Equus caballus
463464 Pan troglodytes
489802 Canis lupus familiaris
549417 Xenopus (Silurana) tropicalis
734640 Xenopus laevis
1364 Homo sapiens
12740 Mus musculus
304407 Rattus norvegicus
395144 Gallus gallus
733578 Sus scrofa
414921 Bos taurus
100720244 Cavia porcellus
100340963 Oryctolagus cuniculus
100856416 Canis lupus familiaris
73934 Mus musculus
688420 Rattus norvegicus
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