Browse our anti-Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C) Antibodies

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anti-Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit Antibodies (CACNA1C)
On www.antibodies-online.com are 190 Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C) Antibodies from 19 different suppliers available. Additionally we are shipping Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit Proteins (10) and Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit Kits (4) and many more products for this protein. A total of 207 Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit products are currently listed.
Synonyms:
C-LTCC, ca(v)1.2, CACH2, CACH2C, CACN2, Cacna1c, CACNL1A1, CAV1.2, Cchl1a1, CHCACHA1C, ICA, isl, LQT8, MBC, MELC-CC, RATIVS302, TS
list all antibodies Gene Name GeneID UniProt
CACNA1C 775 Q13936
CACNA1C 12288 Q01815
CACNA1C 24239 P22002

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All available anti-Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit Antibodies

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Top referenced anti-Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit Antibodies

  1. Hamster Monoclonal CACNA1C Primary Antibody for AA, ICC - ABIN361759 : Krey, Moussay, Thiel, Ruemenapf: Role of the low-density lipoprotein receptor in entry of bovine viral diarrhea virus. in Journal of virology 2006 (PubMed)
    Show all 3 references for 361759

  2. Human Polyclonal CACNA1C Primary Antibody for EIA, IP - ABIN1105621 : Lemke, Welling, Christel, Blaich, Bernhard, Lenhardt, Hofmann, Moosmang: Unchanged beta-adrenergic stimulation of cardiac L-type calcium channels in Ca v 1.2 phosphorylation site S1928A mutant mice. in The Journal of biological chemistry 2008 (PubMed)

  3. Human Polyclonal CACNA1C Primary Antibody for BP, IP - ABIN452092 : Eden, Meder, Völkers, Poomvanicha, Domes, Branchereau, Marck, Will, Bernt, Rangrez, Busch, Hrabě de Angelis, Heymes, Rottbauer, Most, Hofmann, Frey: Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression. in Nature communications 2016 (PubMed)

  4. Human Polyclonal CACNA1C Primary Antibody for ELISA, WB - ABIN449706 : Saud, Minobe, Wang, Han, Horiuchi, Hao, Kameyama: Calpastatin binds to a calmodulin-binding site of cardiac Cav1.2 Ca2+ channels. in Biochemical and biophysical research communications 2007 (PubMed)

  5. Human Polyclonal CACNA1C Primary Antibody for IHC, WB - ABIN1742110 : Kreuzberg, Theissen, Schicha, Schröder, Mehlhorn, de Vivie, Bokník, Neumann, Grohé, Herzig: Single-channel activity and expression of atrial L-type Ca(2+) channels in patients with latent hyperthyroidism. in American journal of physiology. Heart and circulatory physiology 2000 (PubMed)

  6. Human Monoclonal CACNA1C Primary Antibody for ICC, IF - ABIN447361 : Carnevale, Vecchione, Mascio, Esposito, Cifelli, Martinello, Landolfi, Selvetella, Grieco, Damato, Franco, Haase, Maffei, Ciraolo, Fucile, Frati, Mazzoni, Hirsch, Lembo: PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism. in Cardiovascular research 2011 (PubMed)

More Antibodies against Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit Interaction Partners

Xenopus laevis Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C) interaction partners

  1. Competitive and non-competitive regulation of calcium-dependent inactivation in CaV1.2 L-type Ca2 (show CA2 Antibodies)+ channels by calmodulin and Ca2 (show CA2 Antibodies)+-binding protein 1.

Rabbit Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C) interaction partners

  1. Surface biotinylation and flow cytometry assays revealed that L-type calcium channel alpha(1C) channels composed of the corresponding alpha-actinin (show ACTN1 Antibodies)-binding-deficient mutants result in a 35-40% reduction in surface expression compared to that of wild-type channels.

  2. a direct physical interaction between the N terminus (NT) and C terminus (CT) of the main subunit of the L-type Ca(2 (show CA2 Antibodies)+) channel CaV1.2, alpha1C, is reported.

  3. These results reveal a new dimension of regulation of Ca(V)1.2 channels through phosphorylation of the Hook domains of their beta subunits.

  4. These findings suggest that N-glycosylation contributes to the surface expression and voltage-dependent gating of Cav1.2.

  5. Data show that cardiac L-type calcium (CaV1.2) channels form clusters that undergo dynamic, reciprocal, allosteric interactions.

  6. these findings provide evidence for a new role of Homer1 (show HOMER1 Antibodies) supporting the regulation of Cav1.2 channels by STIM1 (show STIM1 Antibodies).

  7. structural flexibility of CaV1.2 and CaV2.2 (show CACNA1B Antibodies) I-II proximal linker

  8. These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.

  9. There were substantial transmural gradients in Cav1.2, KChIP2 (show KCNIP2 Antibodies), ERG (show KCNH2 Antibodies), KvLQT1 (show KCNQ1 Antibodies), Kir2.1 (show KCNJ2 Antibodies), NCX1 (show SLC8A1 Antibodies), SERCA2a (show ATP2A2 Antibodies) and RyR2 (show RYR2 Antibodies) at the mRNA and, in some cases, protein level-in every case the mRNA or protein was more abundant in the epicardium than the endocardium.

  10. Ca v1.2 binding site for PP2A and PP2B

Human Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C) interaction partners

  1. CACNA1C variants for psychiatric disorders were found to be associated with long sleep latency among 8-month-old infants.

  2. In type 2 diabtes beta cells, exocytosis was slower and not synchronized with membrane depolarizations, and neither Ca2 (show CA2 Antibodies)+ influx nor CaV1.2 was concentrated at insulin (show INS Antibodies) granules.

  3. the loss-of-function CACNA1C-Q1916R mutation contributed to Early repolarization syndrome-related sudden cardiac death.

  4. BIMU8 is a potent blocker of hERG (show KCNH2 Antibodies), NaV1.5 (show SCN5A Antibodies) and CaV1.2 cardiac ion channels, inducing cardiac arrhythmias.

  5. CACNA1C rs1006737 SNP and SNPs in linkage disequilibrium with it may influence the risk of QTc prolongation in patients treated with psychotropic drugs with cardiovascular risk

  6. Functional Characterization of Schizophrenia-Associated Variation in CACNA1C

  7. Authors assessed the effect across the human brain of the CACNA1C rs1006737 genotype on FA, in a Caucasian clinical sample as well as in health, and whether this genotype effect was different between diagnostic groups and whether it interacted with the ZNF804A rs1344706 genotype.

  8. The study supports the association of SNP rs1006737 with bipolar disorder-I (BD-I) and suggests that CACNA1C SNP rs1006737 and Bcl-2 SNP rs956572, or specific causal variants in linkage disequilibrium with these proxies, act independently to increase risk and Intracellular Ca(2+) dyshomeostasis (ICDH) in BD-I.

  9. The Ca channel alpha 1C (CACNA1C) mRNA and protein expressions were noticeably elevated in H-Cd group. These findings suggest that CACNA1C might be implicated in Cd transport in human placenta.

  10. Rare CACNA1C genetic variants may contribute to the underlying pathogenic basis for some cases of sudden explaned dealth in the young in either a gain or loss-of-function mechanism.

Mouse (Murine) Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C) interaction partners

  1. The present study shows that ANO1 (show ANO1 Antibodies) and CavL play a central role in the generation of slow waves, phasic contractions and tone in the internal anal sphincter and that this pathway can occur in the absence of stretch

  2. Cacna1c haploinsufficient mice lack normal sensitivity to inhibition of the dopamine transporter. Cacna1c is crucial for normal behavioral responses to DA stimulants.

  3. Data (including data from studies using transgenic/knockout mice) suggest Cacna1c is involved in specific aspects of learning (behavioral strategies for increasing reward rate); majority of Cacna1c knockout mice manage to increase reward feedback across trials but appear to do so by adapting outcome-based behavioral strategy, while majority of control mice appear to adopt experimentally intended cue-association behavior.

  4. This study showed that Cav1.2, but not Cav1.3 (show CACNA1D Antibodies), L-type calcium channel subtype mediates nicotine-induced conditioned place preference in mice.

  5. We report that the protein densin-180 (show LRRC7 Antibodies) is highly enriched at excitatory synapses in the brain and enhances the cell surface trafficking and postsynaptic localization of Cav1.2 L-type Ca(2 (show CA2 Antibodies)+) channels in neurons. This interaction promotes coupling of Cav1.2 channels to activity-dependent gene transcription.

  6. These results indicate that Cav1.2 modulates oligodendrocyte development and suggest that Ca(2 (show CA2 Antibodies)+) influx mediated by L-type voltage-operated Ca(2 (show CA2 Antibodies)+) channels inoligodendrocyte progenitor cells is necessary for normal myelination

  7. The authors show that phosphorylation of S1928 displaces the beta-2 adrenergic receptor (show ADRB2 Antibodies) from Cav1.2 upon beta-adrenergic stimulation rendering Cav1.2 refractory for several minutes from further beta-adrenergic stimulation.

  8. findings suggest that Hap1 (show HAP1 Antibodies) is important for insulin (show INS Antibodies) secretion of pancreatic beta-cells via regulating the intracellular trafficking and plasma membrane localization of Cav1.2, providing new insight into the mechanisms that regulate insulin (show INS Antibodies) release from pancreatic beta-cells.

  9. these data indicate for the first time a functional interaction between Orai1 (show TMEM132A Antibodies), TRPC1 (show TRPC1 Antibodies), and CaV1.2 channels in Vascular Smooth Muscle Cells, confirming that upon agonist stimulation, vessel contraction involves Ca(2 (show CA2 Antibodies)+) entry due to co-activation of Orai1 (show TMEM132A Antibodies)- and TRPC1 (show TRPC1 Antibodies)-dependent store-operated Ca(2 (show CA2 Antibodies)+) channels and L-type Ca(2 (show CA2 Antibodies)+) channels.

  10. These findings suggest that Trpc3 (show TRPC3 Antibodies) is a mediator of pathologic cardiac hypertrophy not only through mediating part of the Ca(2 (show CA2 Antibodies)+) influx, but also through control of CaV1.2 expressions.

Cow (Bovine) Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C) interaction partners

  1. These results suggest that structural rearrangements of CaV1.2 generated through the binding of BayK8644 or FPL64176, by altering the channel activity, could affect depolarization-evoked catecholamine secretion prior to cation transport.

  2. CaV3.1 (show CACNA1G Antibodies) structural analysis and comparison to CaV1.2 channel

Guinea Pig Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C) interaction partners

  1. findings suggested that the expressions of the cardiac CACNA1C were under the CLOCK-BMAL1 (show ARNTL Antibodies) regulation, probably through the PI3K-Akt (show AKT1 Antibodies) signal pathway

  2. These results suggest that PKA and phosphatase(s) attached on or near the Ca(V)1.2 channel regulate the basal channel activity, presumably through modulation of the dynamic CaM (show CALM Antibodies) interaction with the channel.

  3. CaM (show CALM Antibodies) may tether to the channel with its single lobe, leading to multiple CaM (show CALM Antibodies) molecule binding to increase the grade of Ca(2 (show CA2 Antibodies)+)-dependent regulation of Cav1.2

Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C) Antigen Profile

Antigen Summary

This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits.

Alternative names and synonyms associated with Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C)

  • calcium channel, voltage-dependent, L type, alpha 1C subunit (cacna1c) antibody
  • calcium channel, voltage-dependent, L type, alpha 1C subunit (CACNA1C) antibody
  • calcium channel (CACB) antibody
  • calcium channel, voltage-dependent, L type, alpha 1C subunit (Cacna1c) antibody
  • cardiac L-type calcium channel (CACH2C) antibody
  • Red blood cell count (RBC) antibody
  • C-LTCC antibody
  • ca(v)1.2 antibody
  • CACH2 antibody
  • CACH2C antibody
  • CACN2 antibody
  • Cacna1c antibody
  • CACNL1A1 antibody
  • CAV1.2 antibody
  • Cchl1a1 antibody
  • CHCACHA1C antibody
  • ICA antibody
  • isl antibody
  • LQT8 antibody
  • MBC antibody
  • MELC-CC antibody
  • RATIVS302 antibody
  • TS antibody

Protein level used designations for CACNA1C

ZfCav1.2 , island beat , voltage-dependent L-type calcium channel subunit alpha-1C , L-type Ca channel alpha 1 subunit , L-type calcium channel CaV1.2 , atrium L-type calcium channel , calcium channel, voltage-dependent, L type, alpha 1C subunit , voltage-dependent L-type calcium channel subunit alpha-1C-like , calcium channel voltage-dependent L type Cav1.2, alpha 1c subunit , CaCB receptor , smooth muscle calcium channel blocker , DHPR, alpha-1 subunit , calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle , calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit , voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10* , L-type Cav1.2 , brain class C , calcium channel voltage-dependent alpha1c subunit , neuronal voltage-gated calcium channel alpha 1C subunit , skeletal muscle-specific calcium channel , voltage-gated calcium channel subunit alpha Cav1.2 , L-type calcium channel alpha-1 subunit , RBC , calcium channel, voltage-dependent, alpha 1C subunit , voltage-gated calcium channel alpha 1C subunit , L-type voltage-gated calcium channel alpha1C subunit ChCaChA1C , L-type voltage-dependent calcium channel alpha-1 subunit , cardiac L-type calcium channel , Voltage-dependent L-type calcium channel subunit alpha-1C

GENE ID SPECIES
170581 Danio rerio
403516 Canis lupus familiaris
100442085 Pongo abelii
100462911 Xenopus laevis
100101555 Oryctolagus cuniculus
775 Homo sapiens
12288 Mus musculus
24239 Rattus norvegicus
408015 Bos taurus
395891 Gallus gallus
100135490 Cavia porcellus
100144322 Oryctolagus cuniculus
101180626 Sus scrofa
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