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It promotes the secretion of glucagon-like peptide-1 (GLP-1 (show GCG ELISA Kits)) in the intestine, and also acts as a lipid sensor in adipose tissue to sense dietary fat and control energy balance.(review)
demonstrated a GPR120-mediated novel anti-inflammatory pathway in specific intestinal epithelial cell types that could be of therapeutic relevance to intestinal inflammatory disorders
GPR120 negatively and GPR40 (show FFAR1 ELISA Kits) positively regulate cellular functions during tumor progression in lung cancer cells.
the low-frequency p.R270H variant which inhibits GPR120 activity might influence fasting glucose levels in a normal physiological range.
GPR120 functions as a receptor for omega-3 fatty acid, involving in regulating the secretion of gastrointestinal peptide (show SPINK4 ELISA Kits) hormone, adipogenesis, adipogenic differentiation and anti-inflammatory process. [review]
Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40 (show FFAR1 ELISA Kits)/FFA1 and GPR120/FFA4
Findings demonstrate the novel functional properties of GPR120 on human eosinophils and indicate the previously unrecognized link between nutrient metabolism and the immune system.
These results suggest that distinct effects of GPR120 and GPR40 (show FFAR1 ELISA Kits) are involved in the acquisition of malignant property in pancreatic cancer cells.
TNFa (show TNF ELISA Kits) decreases GLP-2 (show GCG ELISA Kits) expression by up-regulating GPR120 in Crohn disease
Morbidly obese subjects had lower GPR120 mRNA and protein levels in visceral adipose tissue and a lower mRNA expression after a high-fat meal in peripheral blood mononuclear cells.
Data suggest phosphorylation of Ffar4 occurs at 3 serine and 2 threonine residues clustered in 2 separable regions of C-terminal tail; recruitment of arrestin 3 (show ARRB2 ELISA Kits), receptor internalization, and activation of Akt (show AKT1 ELISA Kits) are regulated by Ffar4 phosphorylation.
GPR120-mediated cellular signalling determines the bi-potential differentiation of BMMSCs in a dose-dependent manner.
GPR 40 (show FFAR1 ELISA Kits)/120 double-knockout mice are impaired in post-oral fat sensing.
co-transfection of GPR120 enhanced eicosapentaenoic acid-induced PPARgamma (show PPARG ELISA Kits) binding to PPAR (show PPARA ELISA Kits)-response element in VEGF-A (show VEGFA ELISA Kits) promoter region.
results indicated that the beneficial metabolic role of DHA was attributed to its ability to regulate glucose via the GPR120-mediated AMPK (show PRKAA1 ELISA Kits) pathway in the skeletal muscles
The GPR120 in mouse pituitary gonadotropes is upregulated by fasting and that it may play a role in controlling gonadotropin secretion.
Results suggest that GPR120 is not indispensable for the improved metabolic profile associated with intake of a diet enriched in n-3 polyunsaturated fatty acids.
GPR120 is expressed abundantly in K cells of the upper small intestine and plays a critical role in lipid-induced GIP (show GIP ELISA Kits) secretion.
The results imply that GPR120 is selectively present within the delta cells of murine islets and that it regulates somatostatin (show SST ELISA Kits) secretion.
GPR120 is highly expressed in porcine mature adipose tissue and is positively associated with adipose tissue development. 5 CpG islands across GPR120 gene exhibit different methylation states. DNA methylation (show HELLS ELISA Kits) of GPR120 5'-untranslated and first exon regions can negatively regulate its expression levels.
C/EBP-beta (show CEBPB ELISA Kits) plays a vital role in regulating GPR120 transcription.
This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene.
G-protein coupled receptor 120
, G-protein coupled receptor 129
, G-protein coupled receptor GT01
, G-protein coupled receptor PGR4
, omega-3 fatty acid receptor 1
, G protein-coupled receptor 120
, G-protein-coupled receptor GT01