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Eicosapentaenoic acid prevents TNF-alpha (show TNF ELISA Kits)-induced decrease of alpha-methylglucose uptake and AMPK (show PRKAA1 ELISA Kits) phosphorylation in Caco-2 cells via GPR120 and AMPK (show PRKAA1 ELISA Kits) activation.
P.R270H of FFAR4 impairs Gq and Gi signalling of FFAR4 in vitro.
G protein-coupled receptor 120 (GPR120) represents a promising target for the treatment of obesity-related metabolic disorders for its involvement in the regulation of adipogenesis, inflammation, glucose uptake, and insulin (show INS ELISA Kits) resistance. This review summarizes recent studies and advances regarding the systemic role of GPR120 in adipose tissue, including both white and brown adipocytes. [review]
p.R270H variant of GPR120 modulates the risk of type 2 diabetes in interaction with dietary fat intake.
These results indicated that GPR120 enhanced and GPR40 (show FFAR1 ELISA Kits) inhibited the cell motile activity of highly migratory osteosarcoma cells.
LPA1 (show LPAR1 ELISA Kits) plays a critical role in EGF (show EGF ELISA Kits) responses and that FFA4 agonists inhibit proliferation by suppressing positive cross-talk between LPA1 (show LPAR1 ELISA Kits) and the EGF receptor (show EGFR ELISA Kits)
Ligands for FFAR4 comprise the family of long chain polyunsaturated fatty acids, suggesting that many of the long-known beneficial effects of these fats may be receptor mediated. (Review)
It promotes the secretion of glucagon-like peptide-1 (GLP-1 (show GCG ELISA Kits)) in the intestine, and also acts as a lipid sensor in adipose tissue to sense dietary fat and control energy balance.(review)
demonstrated a GPR120-mediated novel anti-inflammatory pathway in specific intestinal epithelial cell types that could be of therapeutic relevance to intestinal inflammatory disorders
GPR120 negatively and GPR40 (show FFAR1 ELISA Kits) positively regulate cellular functions during tumor progression in lung cancer cells.
These data reveal important structure-function and signaling differences between the two FFA4 isoforms, and for the first time link FFA4 to modulation of ROS (show ROS1 ELISA Kits) in macrophages.
Results provide evidence that GPR120 promotes adipogenesis by increasing PPARgamma (show PPARG ELISA Kits) expression via [Ca(2 (show CA2 ELISA Kits)+)]i and ERK1/2 (show MAPK1/3 ELISA Kits) signal pathway in 3T3-L1 adipocytes.
GPR120-induced incretin glucse-dependent insulinotropic polypeptide secretion is indirectly mediated by cholecystokinin (show CCK ELISA Kits).
Leukocyte GPR120/FFAR4 WT or KO mice in the LDL receptor (show LDLR ELISA Kits) KO background were generated by bone marrow transplantation.leukocyte GPR120 expression has minimal effects on dietary PUFA-induced plasma lipid/lipoprotein reduction and atheroprotection, and there is no distinction between n-3 versus n-6 PUFAs in activating anti-inflammatory effects of leukocyte GPR120/FFAR4 in vivo
Collectively, these findings showed that SA suppressed mammary gland development of pubertal mice, which was coincident with the SA-inhibited HC11 (show CCL2 ELISA Kits) proliferation, and was associated with inhibition of PI3K/Akt (show AKT1 ELISA Kits) signaling pathway through activation of GPR120.
GPR120 silencing in adipocytes inhibited the expression of PPARgamma (show PPARG ELISA Kits) and miR (show MLXIP ELISA Kits)-143, whereas GPR120 overexpression led to increased expressions of PPARgamma (show PPARG ELISA Kits) and miR (show MLXIP ELISA Kits)-143.
GPR120 expression in beta-cells and GPR120-mediated insulinotropic effects are altered in obesity and diabetic states in distinct ways, and these alterations may be mediated by PPARgamma (show PPARG ELISA Kits).
Data show that agonizing G protein-coupled receptor 120 (GPR120) differentially regulates the pro-inflammatory adipocytokines.
work identifies a novel function of Ffar4 in modulating brown adipogenesis partly through a mechanism involving cAMP activation and up-regulation of miR (show MLXIP ELISA Kits)-30b and miR (show MLXIP ELISA Kits)-378.
GPR120 is a negative modulator of osteoclast development.
GPR120 is highly expressed in porcine mature adipose tissue and is positively associated with adipose tissue development. 5 CpG islands across GPR120 gene exhibit different methylation states. DNA methylation (show HELLS ELISA Kits) of GPR120 5'-untranslated and first exon regions can negatively regulate its expression levels.
C/EBP-beta (show CEBPB ELISA Kits) plays a vital role in regulating GPR120 transcription.
This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene.
G-protein coupled receptor 120
, G-protein coupled receptor 129
, G-protein coupled receptor GT01
, G-protein coupled receptor PGR4
, omega-3 fatty acid receptor 1
, G protein-coupled receptor 120
, G-protein-coupled receptor GT01