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PIP4K2B couples the cellular GTP (show AK3 Proteins) concentration to the levels of the stress-regulated phosphoinositide PtdIns5P, to impact on tumor cell growth.
Suppression of PIP4K expression selectively prevents tumor cell growth in vitro and prevents tumor development in mice that have lost the tumor suppressor p53 (show TP53 Proteins). (Review)
Association between low PIP4K2B expression and poor patient survival.Analysis of gene expression datasets confirmed the association between low PIP4K2B and low CDH1expression.
Knocking down PI5P4Kalpha and beta in a breast cancer cell line bearing an amplification of the gene encoding PI5P4K beta and deficient for p53 (show TP53 Proteins) impaired growth on plastic and in xenografts.
These results indicate that PIPKIIbeta-mediated PI(4,5)P(2) signaling is important for E-cadherin upregulation and inhibition of cellular motility induced by VDR activation.
The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor.
phosphatidylinositol-4-phosphate 5-kinase, type II, beta
, phosphatidylinositol-5-phosphate 4-kinase type-2 beta
, phosphatidylinositol-5-phosphate 4-kinase, type II, beta
, phosphatidylinositol-4-phosphate 5-kinase type II beta
, phosphatidylinositol-5-phosphate 4-kinase type-2 beta-like
, 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta
, 1-phosphatidylinositol-4-phosphate kinase
, 1-phosphatidylinositol-5-phosphate 4-kinase 2-beta
, PI(5)P 4-kinase type II beta
, diphosphoinositide kinase 2-beta
, phosphatidylinositol 5-phosphate 4-kinase type II beta
, phosphatidylinositol 5-phosphate 4-kinase type-2 beta
, ptdIns(5)P-4-kinase isoform 2-beta
, 1-phosphatidylinositol-5-phosphate 4-kinase B
, phosphatidylinositol-phosphate kinase IIgamma