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Human FKBP4 Protein expressed in Wheat germ - ABIN1354126
Ardi, Alexander, Johnson, McAlpine: Macrocycles that inhibit the binding between heat shock protein 90 and TPR-containing proteins. in ACS chemical biology 2011
Study demonstrates that FKBP52 by itself does not directly affect cognition and may play an indirect, modulatory role in the functional pathology of Alzheimer's disease, whereas it directly affects motor coordination, an early sign of neurodegenerative damages to the brain.
identify a novel steroid-responsive FKBP52-dependent pathway suppressing the expression and activity of tryptophan-2,3-dioxygenase (show TDO2 Proteins)
study identifies Fkbp4 and Fkbp5 as novel components of the Ago2 RISC loading complex
FKBP52 is not involved in all branches of GR signaling, but rather acts in a gene-specific manner to regulate GR transcriptional activation.
FKBP52 regulates androgen receptor (show AR Proteins) function through the BF3 surface.
Findings suggest that Fkbp52 deficiency diminishes the threshold against OS by reducing PRDX6 (show PRDX6 Proteins) levels.
Fkbp52 is an important molecular regulator in the androgen-mediated pathway of urethra morphogenesis.
Data propose a model in which FKBP52 loss reduces GR control of gluconeogenesis, predisposing the liver to steatosis under HF-diet conditions attributable to a shunting of metabolism from glucose production to lipogenesis.
a Hoxa10 (show HOXA10 Proteins)-FKBP52 signaling axis is critical to uterine receptivity and implantation
FKBP52 is an AR folding factor that has critically important physiological roles in some male reproductive tissues
ID4 (show ID4 Proteins) selectively regulates AR activity through direct interaction with FKBP52.
FKBP52 could be abnormally released from NFTs negative neurons in AD brains in correlation with the early pathologic Tau-D(421) neuronal accumulation.
Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP's capability to dephosphorylate AKT (show AKT1 Proteins).
Low expression of FKBP4 is associated with Progesterone Resistance in Endometriosis.
Results provide a molecular mechanism by which FKBP52 modulates telomerase activity by promoting dynein-dynactin (show DCTN1 Proteins)-dependent nuclear import of hTERT.
The Hsp90 (show HSP90 Proteins)-associated FKBP52 cochaperone has become increasingly associated with aberrant steroid hormone receptor (show NR4A1 Proteins) signaling in disease. [review]
The capacity FKBP52 to oligomerize Tau is not linked to its peptidyl-prolyl isomerase activity.
FKBP52 and beta-catenin (show CTNNB1 Proteins) interact directly in vitro. FKBP52 promotes beta-catenin (show CTNNB1 Proteins) interaction with androgen receptor (show AR Proteins) signaling.
FKBP4 was not differentially expressed in PTSD patients with low HPA (show HPSE Proteins) axis reactivity compared to PTSD patients with high HPA (show HPSE Proteins) axis reactivity.
FKBP51 is the major target accounting for the neuritotrophic effect of neuroimmunophilin ligands. Selectivity against the homolog FKBP52 is essential for optimal neuritotrophic efficacy.
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene.
peptidyl-prolyl cis-trans isomerase FKBP4
, FK506-binding protein 4
, FK506 binding protein 4, 59kDa
, peptidyl-prolyl cis-trans isomerase FKBP4-like
, 52 kDa FK506-binding protein
, 52 kDa FKBP
, 59 kDa immunophilin
, HSP-binding immunophilin
, PPIase FKBP4
, immunophilin FKBP52
, FK506 binding protein 52
, FKBP52 protein
, 51 kDa FK506-binding protein
, FK506-binding protein 4 (59kD)
, HSP binding immunophilin
, T-cell FK506-binding protein, 59kD
, peptidylprolyl cis-trans isomerase
, hsp90 binding protein
, p59 protein