FKBP4 Protein (Myc-DYKDDDDK Tag)
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- Target See all FKBP4 Proteins
- FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This FKBP4 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human FKBP4 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product FKBP4 Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))
- Alternative Name
- Fkbp4 (FKBP4 Products)
- Synonyms
- HBI Protein, p52 Protein, hsp56 Protein, PPIase Protein, fkbp52 Protein, fkbp59 Protein, MGC81078 Protein, wu:fb34f09 Protein, 59kDa Protein, AL022792 Protein, AW208983 Protein, FKBP-4 Protein, FKBP-52 Protein, FKBP52 Protein, FKPB52 Protein, p59 Protein, FKBP51 Protein, FKBP59 Protein, Hsp56 Protein, P59 Protein, FK506 binding protein 4 Protein, FK506 binding protein 4 S homeolog Protein, FKBP4 Protein, fkbp4.S Protein, fkbp4 Protein, Fkbp4 Protein
- Background
- The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene.
- Molecular Weight
- 51.6 kDa
- NCBI Accession
- NP_002005
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway
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