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|Application / Reactivity||Rat (Rattus)||Mouse (Murine)|
|ELISA||14 Antibodies||16 Antibodies|
|ELISA (Capture)||4 Antibodies||4 Antibodies|
|ELISpot (Capture) (ELISPOT (Capture))||2 Antibodies||2 Antibodies|
|Flow Cytometry (FACS)||2 Antibodies||15 Antibodies|
|Immunocytochemistry (ICC)||5 Antibodies|
|Immunofluorescence (IF)||2 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||5 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||5 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||8 Antibodies|
|Intracellular Flow Cytometry (ICFC)||4 Antibodies|
|Neutralization (Neut)||2 Antibodies|
|Western Blotting (WB)||17 Antibodies|
|Blocking Reagent (BR)||2 Antibodies|
|Functional Studies (Func)||2 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Antigen||Interleukin-6 Receptor (IL6R) Antibodies|
|Reactivity||Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This IL-6 Receptor antibody is conjugated to PE Alternatives|
ELISA (Capture), Immunofluorescence (IF)
|11 references available|
|Supplier||Log in to see|
Product Details anti-IL-6 Receptor AntibodyTarget Details IL-6 Receptor Application Details Handling References for anti-IL-6 Receptor Antibody (ABIN2662993) Images
|Purification||The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.|
Target Details IL-6 ReceptorProduct Details anti-IL-6 Receptor Antibody Application Details Handling References for anti-IL-6 Receptor Antibody (ABIN2662993) Images back to top
|Alternative Name||CD126 (IL6R Antibody Abstract)|
|Background||CD126 is an 80 kD IL-6 receptor α chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on activated T and B cells, monocytes, hepatocytes, and plasma cells. High affinity IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor β chain (CD130 or gp130). CD126 binds IL-6 with low affinity, but does not signal. The β chain (gp130, CD130) does not bind IL-6 by itself, but associates with the α-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. The D7715A7 (15A7) antibody blocks IL-6/IL-6 receptor interactions.|
Application DetailsProduct Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Handling References for anti-IL-6 Receptor Antibody (ABIN2662993) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details References for anti-IL-6 Receptor Antibody (ABIN2662993) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-IL-6 Receptor Antibody (ABIN2662993)Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details Handling Images back to top
Sintes, Romero, de Salort et al.: "Mouse CD84 is a pan-leukocyte cell-surface molecule that modulates LPS-induced cytokine secretion by macrophages." in: Journal of leukocyte biology, Vol. 88, Issue 4, pp. 687-97, 2010 (PubMed).
Yadav, Rosenbaum, Goetzl: "Cutting edge: vasoactive intestinal peptide (VIP) induces differentiation of Th17 cells with a distinctive cytokine profile." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 5, pp. 2772-6, 2008 (PubMed).
Walker, Zhang, Matthews et al.: "IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice." in: Blood, Vol. 111, Issue 8, pp. 3978-85, 2008 (PubMed).
Koizumi, Yamaguchi, Kawabata et al.: "Fiber-modified adenovirus vectors decrease liver toxicity through reduced IL-6 production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 3, pp. 1767-73, 2007 (PubMed).
Weigert, Hennige, Lehmann et al.: "Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells." in: The Journal of biological chemistry, Vol. 281, Issue 11, pp. 7060-7, 2006 (PubMed).
Sun, Tian, Kulkarni et al.: "IL-6 prevents T cell-mediated hepatitis via inhibition of NKT cells in CD4+ T cell- and STAT3-dependent manners." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 9, pp. 5648-55, 2004 (PubMed).
Boulanger, Chow, Brevnova et al.: "Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex." in: Science (New York, N.Y.), Vol. 300, Issue 5628, pp. 2101-4, 2003 (PubMed).
McKinney, Jaskot, Richards et al.: "Cytokine mediation of ozone-induced pulmonary adaptation." in: American journal of respiratory cell and molecular biology, Vol. 18, Issue 5, pp. 696-705, 1998 (PubMed).
Taga, Kishimoto: "Gp130 and the interleukin-6 family of cytokines." in: Annual review of immunology, Vol. 15, pp. 797-819, 1997 (PubMed).
Vink, Coulie, Warnier et al.: "Mouse plasmacytoma growth in vivo: enhancement by interleukin 6 (IL-6) and inhibition by antibodies directed against IL-6 or its receptor." in: The Journal of experimental medicine, Vol. 172, Issue 3, pp. 997-1000, 1990 (PubMed).
Coulie, Vink, Van Snick: "A monoclonal antibody specific for the murine IL-6-receptor inhibits the growth of a mouse plasmacytoma in vivo." in: Current topics in microbiology and immunology, Vol. 166, pp. 43-6, 1991 (PubMed).
ImagesProduct Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details Handling References for anti-IL-6 Receptor Antibody (ABIN2662993) back to top