|Application / Reactivity||Human|
|Enzyme Immunoassay (EIA)||1 Antibodies|
|Flow Cytometry (FACS)||17 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies|
|Immunofluorescence (IF)||1 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||10 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||4 Antibodies|
|Neutralization (Neut)||1 Antibodies|
|Western Blotting (WB)||53 Antibodies|
|Antigen||Interleukin 2 Receptor, gamma (IL2RG) Antibodies|
|Conjugate||This IL2RG antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)
|6 references available|
|Supplier||Log in to see|
Product Details anti-IL2RG AntibodyTarget Details IL2RG Application Details Handling References for anti-IL2RG Antibody (ABIN2665537) Images
|Purification||The LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.|
|Sterility||0.2 μm filtered|
Endotoxin level is <0.1 EU/μg of the protein (<0.01 ng/μg of the protein) as determined by the LAL test.
Target Details IL2RGProduct Details anti-IL2RG Antibody Application Details Handling References for anti-IL2RG Antibody (ABIN2665537) Images back to top
|Alternative Name||CD132 (IL2RG Antibody Abstract)|
|Background||CD132 is a 64-70 kD type I transmembrane glycoprotein of the Ig superfamily, also known as common γ chain (γc), or IL-2 receptor γ subunit. It is expressed broadly on T- and B-lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an essential component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21. Ligand binding induces tyrosine phosphorylation and initiates signaling through a JAK/STAT pathway. CD132 mutation results in X-linked severe combined immune deficiency (XSCID).|
Application DetailsProduct Details anti-IL2RG Antibody Target Details IL2RG Handling References for anti-IL2RG Antibody (ABIN2665537) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL2RG Antibody Target Details IL2RG Application Details References for anti-IL2RG Antibody (ABIN2665537) Images back to top
|Handling Advice||This LEAF™ solution contains no preservative, handle under aseptic conditions|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-IL2RG Antibody (ABIN2665537)Product Details anti-IL2RG Antibody Target Details IL2RG Application Details Handling Images back to top
Habib, Senadheera, Weinberg et al.: "The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3." in: Biochemistry, Vol. 41, Issue 27, pp. 8725-31, 2002 (PubMed).
Itano, Tsuchiya, Morita et al.: "IL-2 receptor gamma chain expression on CD34 positive hematopoietic progenitor cells from bone marrow and cord blood." in: The Tohoku journal of experimental medicine, Vol. 178, Issue 4, pp. 389-98, 1996 (PubMed).
Kondo, Takeshita, Ishii et al.: "Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4." in: Science (New York, N.Y.), Vol. 262, Issue 5141, pp. 1874-7, 1994 (PubMed).
Nakarai, Robertson, Streuli et al.: "Interleukin 2 receptor gamma chain expression on resting and activated lymphoid cells." in: The Journal of experimental medicine, Vol. 180, Issue 1, pp. 241-51, 1994 (PubMed).
Matthews, Clark, Herbert et al.: "Function of the interleukin-2 (IL-2) receptor gamma-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-15." in: Blood, Vol. 85, Issue 1, pp. 38-42, 1995 (PubMed).
Kawahara, Minami, Miyazaki et al.: "Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 19, pp. 8724-8, 1995 (PubMed).