anti-Human IL2RG antibody for Neutralization

Recommended IL2RG Antibody (supplied by: Log in to see )

Antigen
Interleukin 2 Receptor, gamma (IL2RG) Antibodies
  • Ab2-183
  • Cd132
  • CD132
  • CIDX
  • IL-2RG
  • IMD4
  • P64
  • SCIDX
  • SCIDX1
  • [g]c
  • gamma(c)
  • gc
  • interleukin 2 receptor, gamma
  • interleukin 2 receptor, gamma chain
  • IL2RG
  • il2rg
  • Il2rg
Epitope
AA 23-254
15
15
11
10
8
8
7
7
7
5
5
4
4
3
3
3
2
2
1
1
Reactivity
Human
120
78
29
2
1
Host
Mouse
88
41
30
2
Clonality
Monoclonal
Conjugate
This IL2RG antibody is un-conjugated
11
10
9
5
5
5
5
5
5
4
4
4
3
3
2
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Neutralization (Neut)
75
68
46
15
13
5
3
3
3
3
2
1
1
1
1
1
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Catalog No. ABIN4899740
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
39.04927 ABIN4899741 FACS Neut WB Goat IgG AA 23-254 Log in to see Polyclonal 3
1 ABIN2291724 FACS Neut ELISA WB Mouse IgG2b AA 23-254 Log in to see 11n93

Top referenced anti-IL2RG antibody for Neutralization

Similar anti-IL2RG Antibodies

Application / Reactivity Human
ELISA 39 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies
Flow Cytometry (FACS) 46 Antibodies
Immunocytochemistry (ICC) 1 Antibodies
Immunofluorescence (IF) 2 Antibodies
Immunofluorescence (fixed cells) (IF/ICC) 1 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 13 Antibodies
Immunohistochemistry (IHC) 13 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 3 Antibodies
Immunoprecipitation (IP) 2 Antibodies
Neutralization (Neut) 3 Antibodies
Western Blotting (WB) 65 Antibodies

General

Antigen Interleukin 2 Receptor, gamma (IL2RG) Antibodies
Epitope AA 23-254
(15), (15), (11), (10), (8), (8), (7), (7), (7), (5), (5), (4), (4), (3), (3), (3), (2), (2), (1), (1)
Reactivity Human
(120), (78), (29), (2), (1)
Host Mouse
(88), (41), (30), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL2RG antibody is un-conjugated
(11), (10), (9), (5), (5), (5), (5), (5), (5), (4), (4), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Application Flow Cytometry (FACS), Neutralization (Neut)
(75), (68), (46), (15), (13), (5), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1)
Pubmed 3 references available
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Product Details anti-IL2RG Antibody

Target Details IL2RG Application Details Handling ProductDetails: References for anti-IL2RG antibody (ABIN4899740) Images
Specificity Detects human Common gamma Chain/IL-2 R gamma in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-2 R alpha , rhIL-2 R beta , rhIL-15 R alpha , recombinant mouse IL-2 R gamma , or recombinant canine IL-2 R alpha is observed. In Western blots, approximately 80 % cross-reactivity with recombinant human IL-2 R beta , 50 % cross-reactivity with rhIL-15 R alpha and recombinant mouse IL-2 R alpha , and no cross-reactivity with rhIL-2 R alpha is observed.
Purification Protein A or G purified from hybridoma culture supernatant
Sterility 0.2 μm filtered
Endotoxin Level <0.10 EU per 1 μg of the antibody by the LAL method.
Immunogen S. frugiperda insect ovarian cell line Sf21-derived recombinant human Common gamma Chain/IL-2 gamma , Leu23-Asn254, Accession # P31785
Clone 633162
Isotype IgG2b

Target Details IL2RG

Product Details anti-IL2RG Antibody Application Details Handling ProductDetails: References for anti-IL2RG antibody (ABIN4899740) Images back to top
Antigen
Alternative Name IL2RG (IL2RG Antibody Abstract)
Background Alternative Names: CD132, CD132 antigen, CIDX, combined immunodeficiency, X-linked, common cytokine receptor gamma chain, common gamma-chain, cytokine receptor common subunit gamma, gamma(c), IL-2 R gamma, IL-2 receptor subunit gamma, IL2R gamma, IL-2R subunit gamma, IL2RG, IL-2RG, IMD4, interleukin 2 receptor, gamma, Interleukin-2 receptor subunit gamma, p64, SCIDX, SCIDX1, severe combined immunodeficiency
Gene ID 3561
UniProt P31785
Pathways JAK-STAT Signaling, Growth Factor Binding

Application Details

Product Details anti-IL2RG Antibody Target Details IL2RG Handling ProductDetails: References for anti-IL2RG antibody (ABIN4899740) Images back to top
Application Notes Flow Cytometry 2.5 μg/10^6 cells
Neutralization 0.08-0.4 μg/mL
CyTOF-ready
Restrictions For Research Use only

Handling

Product Details anti-IL2RG Antibody Target Details IL2RG Application Details ProductDetails: References for anti-IL2RG antibody (ABIN4899740) Images back to top
Reconstitution Sterile PBS to a final concentration of 0.5 mg/mL.
Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative Without preservative
Storage 4 °C,-20 °C,-80 °C
Storage Comment Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20°C to -70°C as supplied. 1 month,2°C to 8°C under sterile conditions after reconstitution. 6 months,-20°C to -70°C under sterile conditions after reconstitution.
Expiry Date 12 months

ProductDetails: References for anti-IL2RG antibody (ABIN4899740)

Product Details anti-IL2RG Antibody Target Details IL2RG Application Details Handling Images back to top
Product cited in:

Jiang, Chen, An, Yang, Zhang, Cheng: "Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling." in: Scientific reports, Vol. 6, pp. 32320, 2016 Method employed by authors: Flow Cytometry (FACS) (Sample species: Human).

Mujib, Jones, Lo, Aidarus, Clayton, Sakhdari, Benko, Kovacs, Ostrowski et al.: "Antigen-independent induction of Tim-3 expression on human T cells by the common ?-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 188, Issue 8, pp. 3745-56, 2012 Method employed by authors: Neutralization (Neut) (Sample species: Human).

Giron-Michel, Azzi, Khawam, Mortier, Caignard, Devocelle, Ferrini, Croce, François, Lecru, Charpentier, Chouaib, Azzarone, Eid: "Interleukin-15 plays a central role in human kidney physiology and cancer through the γc signaling pathway." in: PLoS ONE, Vol. 7, Issue 2, pp. e31624, 2012 Method employed by authors: Neutralization (Neut) (Sample species: Human).

Images

Product Details anti-IL2RG Antibody Target Details IL2RG Application Details Handling ProductDetails: References for anti-IL2RG antibody (ABIN4899740) back to top
Supplier Images
Neutralization (Neut) image for anti-IL2RG antibody (Interleukin 2 Receptor, gamma) (AA 23-254) (ABIN4899740) Cell Proliferation Induced by IL-2 and Neutralization by Human Common gamma Chain/ IL...
Flow Cytometry (FACS) image for anti-IL2RG antibody (Interleukin 2 Receptor, gamma) (AA 23-254) (ABIN4899740) Detection of Common gamma Chain/IL-2 R gamma in Human PBMC by Flow Cytometry. Human p...