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Single nucleotide polymorphism c.459A > G in the IRF9 gene significantly decreased the IFN-gamma (show IFNG Proteins) concentration and increased the ratio of IFN-gamma (show IFNG Proteins)/IL-10 (show IL10 Proteins) in serum of piglets after challenged with classical swine fever vaccine.
Interferonstimulated gene factor 3 complex, which consists of STAT1 (show STAT1 Proteins), STAT2 (show STAT2 Proteins) and IRF9, is required for the induction of SAMHD1 (show SAMHD1 Proteins) expression by IFN-alpha (show IFNA Proteins) in SMMC-7721 cells.
U-ISGF3 (show STAT1 Proteins) induced by IFN-lambdas and -beta drives prolonged expression of a set of IFN-stimulated genes during HCV infection
IRF9 is a vascular injury-response molecule that promotes VSMC proliferation. IRF9 expression is upregulated during neointima formation.
DC-SIGN (show CD209 Proteins)-induced ISGF3 (show STAT1 Proteins) by fucose-based PAMPs has an essential role in driving IL-27 (show IL27 Proteins) and subsequent TFH polarization, which might be harnessed for vaccination design
IRF9 mediated myocardial reperfusion injury
STAT2 (show STAT2 Proteins) and IRF9 overexpression is sufficient to drive interferon (show IFNA Proteins)-related DNA damage signature expression upon cell crowding.
IL6 (show IL6 Proteins) is an inducer of IRF9 expression in prostate cancer and a sensitizer for the antiproliferative effects of IFNalpha2 (show IFNA2 Proteins).
The hepatitis C virus (HCV) non-structural 5A (NS5A) protein, which is known to modulate the IFN response, competes with IRF9 for CypA (show PPIA Proteins) binding and can prevent the formation of IRF9-CypA (show PPIA Proteins) complexes.
HDAC1 (show HDAC1 Proteins) and HDAC2 (show HDAC2 Proteins) differentially modulate STAT (show STAT1 Proteins) activity in response to IFNalpha2 (show IFNA2 Proteins): while they are required for the induction of ISGF3 (show STAT1 Proteins)-responsive genes, they impair the transcription of STAT3 (show STAT3 Proteins)-dependent genes.
Western blot and electrophoretic mobility-shift assays identified the interferon (show IFNA Proteins)-stimulated gene factor-3 (ISGF-3 (show STAT1 Proteins)) components STAT1 (show STAT1 Proteins) and IRF-9 as the proximal targets of human herpesvirus 8 vIRF-2 activity.
Much more significant induction of zebrafish IRF9 by zebrafish IFNgamma2.
IFN-alpha (show IFNA Proteins)/beta is able to drive the formation of a Stat2 (show STAT2 Proteins) and IRF-9 complex that drives the expression of a subset of IFN-stimulated genes, but with substantially delayed kinetics.
In a murine model of dextran sodium sulfate -induced colitis, IRF9 deficiency protects animals, whereas the combined loss of interferon (show IFNA Proteins) I and interferon (show IFNA Proteins) III receptors worsens their condition.
STAT2 (show STAT2 Proteins)/IRF9 regulates antiviral activity through a prolonged ISGF3-like transcriptional response.
IRF9 directly activates neuronal death signaling pathways through the downregulation of Sirt1 (show SIRT1 Proteins) deacetylase in response to acute I/R stress.
IFN-beta (show IFNB1 Proteins)-induced necroptosis of macrophages proceeds through tonic IFN-stimulated gene factor 3 (ISGF3) signaling, which leads to persistent expression of STAT1 (show STAT1 Proteins), STAT2 (show STAT2 Proteins), and IRF9 and sustained Rip3 activation.
IRF9 inhibits the development of cardiac hypertrophy by suppressing the transcriptional activity of myocardin in the heart.
Interferon regulatory factor 9 protects against hepatic insulin (show INS Proteins) resistance and steatosis in male mice.
STAT1 (show STAT1 Proteins), not STAT2 (show STAT2 Proteins) or IRF9, prevent the emergence of a lethal antiviral CD4 (show CD4 Proteins)(+) T-cell response after lymphocytic choriomeningitis virus infection.
Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
interferon regulatory factor 9
, interferon-stimulated transcription factor 3, gamma 48kDa
, IFN-alpha-responsive transcription factor subunit
, ISGF-3 gamma
, ISGF3 p48 subunit
, interferon-stimulated gene factor 3 gamma
, interferon-stimulated transcription factor 3, gamma (48kD)
, transcriptional regulator ISGF3 subunit gamma
, interferon dependent positive acting transcription factor 3 gamma