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OSMR-beta deficiency in macrophages improved high-fat diet-induced atherogenesis and plaque vulnerability
OSM and OSMR are highly expressed in inflammatory bowel disease intestinal mucosa compared to control mucosa. Intestinal stromal cells express abundant OSMR.
OSM:OSMR interactions are able to induce EMT (show ITK ELISA Kits), increased cancer stem cell-like properties and enhanced lung colonisation in SCC (show CYP11A1 ELISA Kits) cells
the RET (show RET ELISA Kits) p.S891A mutation combined with OSMR p.G513D may underlie a novel phenotype manifesting as familial medullary thyroid carcinoma and cutaneous amyloidosis
this study offers new findings on the molecular genetics and disease relevance of mutations in OSMR in Familial primary localized cutaneous amyloidosis.
Oncostatin M (show OSM ELISA Kits) and interleukin-31 (show IL31 ELISA Kits): Cytokines, receptors, signal transduction and physiology.
primary localized cutaneous amyloidosis has a missense mutation in oncostatin M receptor beta
The interleukin IL-31 (show IL31 ELISA Kits)/IL-31receptor axis contributes to tumor growth in human follicular lymphoma.
oncostatin M (show OSM ELISA Kits) is a cytokine possessing vigorous antiviral and immunostimulatory properties which is released by APC (show APC ELISA Kits) upon interaction with CD40L (show CD40LG ELISA Kits) present on activated CD4 (show CD4 ELISA Kits)+ T cells.
The disease severity of rheumatoid arthritis and systemic lupus erythematosus can be partially affected by the OSMR promoter polymorphisms.
Osmr expression in healthy mouse colon tissue was detected in endothelial and stromal cells. In agreement with observations of increased OSMR expression in inflamed colon tissue, the number of cells expressing Osmr was markedly increased in the lamina propria of mice with colitis.
In astrocytes but not microglia, phosphorylation of STAT1 (show STAT1 ELISA Kits) and STAT3 (show STAT3 ELISA Kits) occurred in response to OSM (show OSM ELISA Kits), whereas both microglia and astrocytes responded to hyper-IL-6 (IL-6 (show IL6 ELISA Kits) linked to the soluble IL-6 (show IL6 ELISA Kits) receptor).
OSM (show OSM ELISA Kits) signaling via OSMR in synovial fibroblasts has the potential to contribute significantly to joint destruction in inflammatory arthritis.
defects in OSM (show OSM ELISA Kits) signaling promote the deterioration of high-fat diet-induced obesity and related metabolic disorders
Data indicate that OSM (show OSM ELISA Kits) receptor beta subunit (show POLG ELISA Kits)-deficient (OSMRbeta(-/-)) mice exhibited phenotypic changes in adipose tissue macrophages (ATMs) to M1, increased proinflammatory cytokines in the adipose tissue, and systemic insulin (show INS ELISA Kits) resistance.
These data indicate that the transient RANKL (show TNFSF11 ELISA Kits) induction by intermittent PTH (show PTH ELISA Kits) administration, which is associated with its anabolic action, is changed to a prolonged induction in OSMR-deficient osteoblasts, resulting in bone destruction.
Bone formation can be stimulated independently of bone resorption and provide new insights into OSMR signaling.
Expression of oncostatin M receptor beta in a specific subset of nociceptive sensory neurons.
This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
IL-31 receptor subunit beta
, IL-31R subunit beta
, interleukin-31 receptor subunit beta
, oncostatin-M specific receptor beta subunit
, oncostatin-M-specific receptor subunit beta
, oncostatin receptor
, oncostatin-M specific receptor subunit beta
, oncostatin M specific receptor