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|Antigen||Protein-tyrosine Phosphatase 1C (PTPN6) Antibodies|
|Conjugate||This PTPN6 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
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Product Details anti-PTPN6 AntibodyTarget Details PTPN6 Application Details Handling Images
|Specificity||This antibody recognizes single 67 kDa PTP1-C in Human cells that express the enzyme and the SH2(C) domain.|
|Purification||Protein G affinity purified|
|Immunogen||Purified recombinant protein corresponding to full-length PTP1-C.|
Target Details PTPN6Product Details anti-PTPN6 Antibody Application Details Handling Images back to top
|Alternative Name||PTPN6 (PTPN6 Antibody Abstract)|
|Background||The phosphorylation state of receptors and signal transduction molecules influences almost every cell activities. The phosphorylation rate is regulated by kinases which add phosphate group and by phosphatases which remove phosphate group form the amino acid residues on protein molecules. Protein tyrosine phosphatase 1 C (PTP1C) is a tyrosine phosphatase highly expressed in heomatopoietic cells. PTP1C was found to co-precipitate with B lymphocytespecific cell surface glycoprotein CD22, after anti-immunoglobulin stimulation. Study with PTP1C deficient mice showed that the phosphatase may implicate with negative selection in B cell immunity.Synonyms: HCP, Hematopoietic cell protein-tyrosine phosphatase, PTP-1C, PTP1C, PTPN-6, Protein-tyrosine phosphatase 1C, Protein-tyrosine phosphatase SHP-1, SH-PTP1, Tyrosine-protein phosphatase non-receptor type 6|
|Pathways||JAK-STAT Signaling, TCR Signaling, TLR Signaling, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2|
Application DetailsProduct Details anti-PTPN6 Antibody Target Details PTPN6 Handling Images back to top
ELISA. Western Blot. Immunohistochemistry on frozen sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-PTPN6 Antibody Target Details PTPN6 Application Details Images back to top
|Reconstitution||Restore with Double distillated water is recommended and to adjust the final concentration to 1.0 mg/mL|
|Buffer||0.01 M PBS, pH 7.2 without preservatives|
|Handling Advice||Avoid repeated freezing and thawing.|