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anti-Human PTPN6 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended PTPN6 Antibody (supplied by: Log in to see )

Antigen
Protein-tyrosine Phosphatase 1C (PTPN6) Antibodies
  • DRPLA
  • HCP
  • hcp
  • HCPH
  • Hcph
  • HPTP1C
  • me
  • motheaten
  • PTP-1C
  • Ptp1C
  • Ptph6
  • SH-PTP1
  • SHP
  • SHP-1
  • Shp-1
  • SHP-1L
  • Shp1
  • SHP1
Reactivity
Human
182
81
76
8
2
2
1
1
1
Host
Mouse
116
35
31
Clonality
Monoclonal
Conjugate
This PTPN6 antibody is un-conjugated
7
7
7
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
136
76
55
30
27
23
9
7
7
6
1
Supplier
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Catalog No. ABIN264440
$ 632.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008982679 ABIN319255 IF IHC (p) Rabbit pTyr536 Log in to see Polyclonal 4
0.0008982679 ABIN197592 IF IHC (p) WB Rabbit Tyr536 Log in to see Polyclonal 4
0.0008982679 ABIN271911 IHC (p) WB Rabbit Log in to see Polyclonal
0.0008982679 ABIN1882123 IF IHC (p) WB Rabbit AA 247-277, Center Log in to see Polyclonal 2
0.0008982679 ABIN954377 EIA IHC (p) WB Mouse IgG1 Log in to see 14D5
0.0008982679 ABIN258467 FACS IHC (p) IP IHC WB Rabbit IgG C-Term Log in to see Y476
0.0008982679 ABIN1103855 IHC (p) ELISA WB Goat Internal Region Log in to see Polyclonal
0.0008982679 ABIN957753 IHC (p) ELISA WB Mouse IgG1, kappa Log in to see 14D5
0.0008982679 ABIN1804594 IHC (p) WB Mouse IgG2b, kappa Log in to see 1SH01
0.0008982679 ABIN711626 IF (p) IHC (p) WB Rabbit IgG pTyr536 Log in to see Polyclonal
0.0008982679 ABIN711641 IF (p) IHC (p) WB Rabbit IgG pSer591 Log in to see Polyclonal
0.0008982679 ABIN957800 IHC (p) ELISA WB Mouse IgG1, kappa Log in to see
0.0008982679 ABIN1724482 IHC (p) ELISA WB Mouse IgG1 kappa Log in to see 14D5
0.0008982679 ABIN1959784 IF IHC (p) Rabbit Tyr536, pTyr536 Log in to see Polyclonal
0.0008982679 ABIN711643 IHC (p) WB Biotin Rabbit IgG pSer591 Log in to see Polyclonal
0.0008982679 ABIN711650 IHC (p) WB HRP Rabbit IgG pSer591 Log in to see Polyclonal
0.0008982679 ABIN1724483 IHC (p) ELISA WB Mouse IgG1 kappa Log in to see
0.0008982679 ABIN408478 IHC (p) IHC WB Rabbit IgG Tyr536 Log in to see Polyclonal
0.0008982679 ABIN1738601 IHC (p) ELISA WB Goat Internal Region Log in to see Polyclonal
0.0008982679 ABIN738083 IHC (p) WB Biotin Rabbit IgG Log in to see Polyclonal

Top referenced anti-PTPN6 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Similar anti-PTPN6 Antibodies

Application / Reactivity Human
ELISA 76 Antibodies
Enzyme Immunoassay (EIA) 7 Antibodies
Flow Cytometry (FACS) 1 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunocytochemistry (ICC) 9 Antibodies
Immunofluorescence (IF) 30 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 23 Antibodies
Immunohistochemistry (IHC) 57 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 6 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 30 Antibodies
Immunoprecipitation (IP) 9 Antibodies
Western Blotting (WB) 139 Antibodies

General

Antigen Protein-tyrosine Phosphatase 1C (PTPN6) Antibodies
Reactivity Human
(182), (81), (76), (8), (2), (2), (1), (1), (1)
Host Mouse
(116), (35), (31)
Clonality (Clone)
Monoclonal   ( )
Conjugate This PTPN6 antibody is un-conjugated
(7), (7), (7), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(136), (76), (55), (30), (27), (23), (9), (7), (7), (6), (1)
Pubmed 5 references available
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Product Details anti-PTPN6 Antibody

Target Details PTPN6 Application Details Handling References for anti-PTPN6 Antibody (ABIN264440) Images
Specificity Recognizes a protein of ~50 kDa, which is identified as the SH2-containing protein-tyrosine phosphatase 1 (SHP-1). This antibody is highly specific to SHP-1 and shows no cross-reaction with other protein-tyrosine phosphatase.
Characteristics Synonyms: PTPN-6, HCP, PTP1C, EC=3.1.3.48, Protein-tyrosine phosphatase 1C, PTP-1C, SH-PTP1,Protein-tyrosine phosphatase SHP-1, Hematopoietic cell protein-tyrosine phosphatase,Tyrosine-protein phosphatase non-receptor type 6
Purification Purified
Immunogen Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized withrecombinant human SHP1 protein and mouse myeloma NS1 cells. Genename: PTPN6
Clone 1SH01
Isotype IgG2b

Target Details PTPN6

Product Details anti-PTPN6 Antibody Application Details Handling References for anti-PTPN6 Antibody (ABIN264440) Images back to top
Antigen
Alternative Name PTPN6 (PTPN6 Antibody Abstract)
Background SHP-1 is known to play a crucial role in the regulation of hematopoiesis and it regulates the transcriptional activity stimulated by the erythropoietin (EPO)-induced JAK/STAT and MAPK pathways and is involved in the signaling machinery responsible for erythroid differentiation and suppression of apoptosis. Furthermore, the observation that SHP-1 associates with RAFTK/Pyk2/CAK activated by beta-chemokine receptor (CCR5) and SHP-1 also associates with the adaptor protein Grb2 and the Src-related kinase Syk indicates the role of SHP-1 in modulating cell migration, proliferation, and immune functions.Synonyms: HCP, Hematopoietic cell protein-tyrosine phosphatase, PTP-1C, PTP1C, PTPN-6, Protein-tyrosine phosphatase 1C, Protein-tyrosine phosphatase SHP-1, SH-PTP1, Tyrosine-protein phosphatase non-receptor type 6
Gene ID 5777
UniProt P29350
Pathways JAK-STAT Signaling, TLR Signaling, Nuclear Receptor Transcription Pathway

Application Details

Product Details anti-PTPN6 Antibody Target Details PTPN6 Handling References for anti-PTPN6 Antibody (ABIN264440) Images back to top
Application Notes Western Blot (1 μg/mL). Immunoprecipitation (2 g/mg of protein lysate). Positive Control: HeLa cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-PTPN6 Antibody Target Details PTPN6 Application Details References for anti-PTPN6 Antibody (ABIN264440) Images back to top
Buffer PBS containing 0.08 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Expiry Date 12 months

References for anti-PTPN6 Antibody (ABIN264440)

Product Details anti-PTPN6 Antibody Target Details PTPN6 Application Details Handling Images back to top
Background publications

Bittorf, Seiler, Zhang, Jaster, Brock: "SHP1 protein tyrosine phosphatase negatively modulates erythroid differentiation and suppression of apoptosis in J2E erythroleukemic cells." in: Biological chemistry, Vol. 380, Issue 10, pp. 1201-9, 2000

Ganju, Brubaker, Chernock, Avraham, Groopman: "Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk." in: The Journal of biological chemistry, Vol. 275, Issue 23, pp. 17263-8, 2000

Xie, Zhang, Siraganian: "Positive regulation of c-Jun N-terminal kinase and TNF-alpha production but not histamine release by SHP-1 in RBL-2H3 mast cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 3, pp. 1521-8, 2000

Daws, Eriksson, Oberg, Ullén, Sentman: "H-2Dd engagement of Ly49A leads directly to Ly49A phosphorylation and recruitment of SHP1." in: Immunology, Vol. 97, Issue 4, pp. 656-64, 1999

Bone, Dechert, Jirik, Schrader, Welham: "SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates." in: The Journal of biological chemistry, Vol. 272, Issue 22, pp. 14470-6, 1997