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anti-Rat (Rattus) PTPN6 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended PTPN6 Antibody (supplied by: Log in to see )

Antigen
Protein-tyrosine Phosphatase 1C (PTPN6) Antibodies
  • DRPLA
  • HCP
  • hcp
  • HCPH
  • Hcph
  • HPTP1C
  • me
  • motheaten
  • PTP-1C
  • Ptp1C
  • Ptph6
  • SH-PTP1
  • SHP
  • SHP-1
  • Shp-1
  • SHP-1L
  • Shp1
  • SHP1
Epitope
pTyr536
33
21
13
9
8
6
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
177
76
72
8
2
2
1
1
1
Host
Rabbit
112
33
32
Clonality
Polyclonal
Conjugate
This PTPN6 antibody is un-conjugated
7
7
7
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
132
74
53
28
25
23
8
7
7
6
1
Supplier
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Catalog No. ABIN319255
$ 357.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.00089487544 ABIN197592 IF IHC (p) WB Rabbit Tyr536 Log in to see Polyclonal 4
0.00089487544 ABIN271911 IHC (p) WB Rabbit Log in to see Polyclonal
0.00089487544 ABIN258467 FACS IHC (p) IP IHC WB Rabbit IgG C-Term Log in to see Y476
0.00089487544 ABIN711641 IF (p) IHC (p) WB Rabbit IgG pSer591 Log in to see Polyclonal
0.00089487544 ABIN711643 IHC (p) WB Biotin Rabbit IgG pSer591 Log in to see Polyclonal
0.00089487544 ABIN711650 IHC (p) WB HRP Rabbit IgG pSer591 Log in to see Polyclonal
0.00089487544 ABIN1738601 IHC (p) ELISA WB Goat Internal Region Log in to see Polyclonal
0.00089487544 ABIN738083 IHC (p) WB Biotin Rabbit IgG Log in to see Polyclonal
0.00089487544 ABIN738090 IHC (p) WB HRP Rabbit IgG Log in to see Polyclonal
0.00089487544 ABIN738081 IF (p) IHC (p) WB Rabbit IgG Log in to see Polyclonal

Top referenced anti-PTPN6 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Similar anti-PTPN6 Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus)
Western Blotting (WB) 136 Antibodies 48 Antibodies 45 Antibodies
Immunoprecipitation (IP) 8 Antibodies 4 Antibodies 4 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 29 Antibodies 12 Antibodies 11 Antibodies
Immunohistochemistry (IHC) 56 Antibodies 40 Antibodies 36 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 6 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 23 Antibodies 22 Antibodies 22 Antibodies
Immunofluorescence (IF) 29 Antibodies 17 Antibodies 16 Antibodies
Immunocytochemistry (ICC) 8 Antibodies

General

Antigen Protein-tyrosine Phosphatase 1C (PTPN6) Antibodies
Epitope pTyr536
(33), (21), (13), (9), (8), (6), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(177), (76), (72), (8), (2), (2), (1), (1), (1)
Host Rabbit
(112), (33), (32)
Clonality
Polyclonal
Conjugate This PTPN6 antibody is un-conjugated
(7), (7), (7), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(132), (74), (53), (28), (25), (23), (8), (7), (7), (6), (1)
Pubmed 4 references available
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Product Details anti-PTPN6 Antibody

Target Details PTPN6 Application Details Handling References for anti-PTPN6 Antibody (ABIN319255) Images
Specificity This Antibody AP08023PU detects endogenous levels of PTPN6/SHP-1 only when phosphorylated at Tyrosine 536.
Purification Affinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human SHP-1 around the phosphorylation site of Tyrosine 536 (S-E-YP-G-N).

Target Details PTPN6

Product Details anti-PTPN6 Antibody Application Details Handling References for anti-PTPN6 Antibody (ABIN319255) Images back to top
Antigen
Alternative Name PTPN6 (PTPN6 Antibody Abstract)
Background SHP1 is a member of the non receptor protein tyrosine phosphatase subfamily. The PTP family comprises of at least 37 proteins, characterized by a catalytic phosphatase domain of approximately 240 amino acids, and includes both transmembrane and cytosolic enzymes. PTP1B is cytosolic. The PTPs have high substrate specificity for phosphotyrosyl proteins, at the primary sequence level sharing little similarity with the protein serine phosphatases, protein threonine phosphatases, or the acid and alkaline phosphatases. SHP1 is implicated in the control of tyrosine kinase signalling pathways in cellular proliferation, with a potential role in cancer.Synonyms: HCP, Hematopoietic cell protein-tyrosine phosphatase, PTP-1C, PTP1C, PTPN-6, Protein-tyrosine phosphatase 1C, Protein-tyrosine phosphatase SHP-1, SH-PTP1, Tyrosine-protein phosphatase non-receptor type 6
Gene ID 5777
NCBI Accession NP_002822
UniProt P29350
Pathways JAK-STAT Signaling, TLR Signaling, Nuclear Receptor Transcription Pathway

Application Details

Product Details anti-PTPN6 Antibody Target Details PTPN6 Handling References for anti-PTPN6 Antibody (ABIN319255) Images back to top
Application Notes Immunofluorescence: 1/100-1/200. Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-PTPN6 Antibody Target Details PTPN6 Application Details References for anti-PTPN6 Antibody (ABIN319255) Images back to top
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at-20 °C.

References for anti-PTPN6 Antibody (ABIN319255)

Product Details anti-PTPN6 Antibody Target Details PTPN6 Application Details Handling Images back to top
Background publications

Kanagasundaram, Jaworowski, Byrne, Hamilton: "Separation and characterization of the activated pool of colony-stimulating factor 1 receptor forming distinct multimeric complexes with signalling molecules in macrophages." in: Molecular and cellular biology, Vol. 19, Issue 6, pp. 4079-92, 1999

Hauck, Gulbins, Lang, Meyer: "Tyrosine phosphatase SHP-1 is involved in CD66-mediated phagocytosis of Opa52-expressing Neisseria gonorrhoeae." in: Infection and immunity, Vol. 67, Issue 10, pp. 5490-4, 1999

Timms, Carlberg, Gu, Chen, Kamatkar, Nadler, Rohrschneider, Neel: "Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages." in: Molecular and cellular biology, Vol. 18, Issue 7, pp. 3838-50, 1998

Migone, Cacalano, Taylor, Yi, Waldmann, Johnston: "Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 7, pp. 3845-50, 1998

Images

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Supplier Images
 image for anti-PTPN6 antibody (Protein-tyrosine Phosphatase 1C) (pTyr536) (ABIN319255) anti-Protein-tyrosine Phosphatase 1C (PTPN6) (pTyr536) antibody
 image for anti-PTPN6 antibody (Protein-tyrosine Phosphatase 1C) (pTyr536) (ABIN319255) anti-Protein-tyrosine Phosphatase 1C (PTPN6) (pTyr536) antibody (Image 2)