Browse our SOCS2 Proteins (SOCS2)

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Suppressor of Cytokine Signaling 2 Proteins (SOCS2)
On are 11 Suppressor of Cytokine Signaling 2 (SOCS2) Proteins from 5 different suppliers available. Additionally we are shipping SOCS2 Antibodies (52) and SOCS2 Kits (14) and many more products for this protein. A total of 82 SOCS2 products are currently listed.
8030460M17, AI527257, AW108012, CIS2, Cish2, D130043N08Rik, hg, JAB, si:dkey-202b22.1, Socs-2, socs2, SSI-2, SSI2, STATI2
list all proteins Gene Name GeneID UniProt
SOCS2 8835 O14508
SOCS2 216233 O35717
SOCS2 84607 O88582

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SOCS2 Proteins (SOCS2) by Origin

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Top referenced SOCS2 Proteins

  1. Human SOCS2 Protein expressed in Wheat germ - ABIN1320927 : Sen, Peng, Woods, Wistuba, Bell, El-Naggar, Lai, Johnson: STAT5A-mediated SOCS2 expression regulates Jak2 and STAT3 activity following c-Src inhibition in head and neck squamous carcinoma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012 (PubMed)

More Proteins for SOCS2 Interaction Partners

Rainbow Trout (Oncorhynchus mykiss) Suppressor of Cytokine Signaling 2 (SOCS2) interaction partners

  1. The upregulation of SOCS-1 (show SOCS1 Proteins) and SOCS-2 by cortisol may be playing a key role in suppressing cytokine signaling and the associated inflammatory response.

Human Suppressor of Cytokine Signaling 2 (SOCS2) interaction partners

  1. Targeting of SOCS2 by miR (show MLXIP Proteins)-194 resulted in derepression of the oncogenic kinases FLT3 (show FLT3 Proteins) and JAK2 (show JAK2 Proteins), leading to enhanced ERK (show EPHB2 Proteins) and STAT3 (show STAT3 Proteins) signaling.

  2. Single-cell RNA sequencing reveals enrichment of homeostatic modules in monocytes and dendritic cells from human metastatic melanoma. Suppressor-of-cytokine-2 (SOCS2) protein, a conserved program transcript, is expressed by mononuclear phagocytes infiltrating primary melanoma and is induced by IFNgamma.

  3. this study shows that IL-7 (show IL7 Proteins) induces the expression of SOCS2 through the JAK (show JAK3 Proteins)/STAT-5 (show STAT5A Proteins) pathway and that SOCS2 interacts with CD127 (show IL7R Proteins) in early endosomes and direct the receptor complex to the proteasome for degradation

  4. Overexpression of SOCS2 inverted these phenotypes generated by hsv2-miR (show MLXIP Proteins)-H9-5p, indicating the potential roles of SOCS2 in Hsv2-miR (show MLXIP Proteins)-H9-5p-driven metastasis in lung cancers. The results highlighted that Hsv2-miR (show MLXIP Proteins)-H9-5p regulated and contributed to bone metastasis of lung cancers. We proposed that Hsv2-miR (show MLXIP Proteins)-H9-5p could be used as a potential target in lung cancer therapy

  5. Overexpression of SOCS-2 is associated with hepatocellular carcinoma.

  6. focus on SOCS2 and review its biological function as well as its implication in pathological processes

  7. SOCS2 may improve outcome of TBI (show TBPL1 Proteins) in mice by regulating aspects of the neuroinflammatory response

  8. This study showed that there was significantly increased levels of SOCS-2 mRNA in elderly and Alzheimer's disease brains.

  9. crystals of SOCS2 in complex with its adaptor proteins, Elongin C (show TCEB1 Proteins) and Elongin B (show TCEB2 Proteins), underwent a change in crystallographic parameters when treated with dimethyl sulfoxide during soaking experiments.

  10. miR (show MLXIP Proteins)-101 functions as a growth-suppressive miRNA in H. pylori related GC, and that its suppressive effects are mediated mainly by repressing SOCS2 expression.

Mouse (Murine) Suppressor of Cytokine Signaling 2 (SOCS2) interaction partners

  1. Our data show that absence of SOCS2 turns cardiomyocytes unresponsive to LIF (show LIF Proteins)-induced [Ca(2 (show CA2 Proteins)+)] raise, indicating that endogenous levels of SOCS2 are crucial for full activation of LIF (show LIF Proteins) signaling in the heart.

  2. Knockdown of SOCS2 makes mice less sensitive to multiple low dose streptozotocin.

  3. Study provides an insight into the role of SOCS2 in modulating the immune response to Bovine herpesvirus 5 [BoHV-5]infection.

  4. Data (including data from studies in knockout mice) suggest Socs2 regulates liver regeneration rate after partial hepatectomy, Ghr (growth hormone receptor (show GHR Proteins)) level via ubiquitination/proteolysis, and serum Igf1 (insulin-like growth factor-1 (show IGF1 Proteins)) level.

  5. GH appears to act directly on the metatarsals of Socs2(-/-) mice, promoting growth via a mechanism that is independent of IGF-1 (show IGF1 Proteins).

  6. comparison of murine wt and Socs2(-/-) HSC (show FUT1 Proteins) gene expression in response to 5-FU revealed a significant overlap with the molecular programs that correlate with SOCS2 expression in leukemias, particularly with the oncogenic pathways

  7. Studies indicate the critical role of suppressor of cytokine signaling 2 (SOCS2) in ontrolling the local growth hormone (GH (show GH1 Proteins)) anabolic bone effects.

  8. Taken together, our observations indicated that SOCS2 could suppress myotube formation, act as an anti-regulator of mitochondria biogenesis via inhibiting p38 MAPK (show MAPK14 Proteins) signal pathway.

  9. SOCS2 immunoprecipitates with TrkA (show NTRK1 Proteins) and a juxtamembrane motif of TrkA (show NTRK1 Proteins) is required for this interaction. Over-expression of SOCS2 in PC12 Tet-On cells increased total and surface TrkA (show NTRK1 Proteins) expression. SOCS2 regulates neurite outgrowth.

  10. Results show that CISH (show CISH Proteins) has no non-redundant functions in beta cell proliferation or glucose homeostasis during pregnancy in mice. Socs2 might compensate for the loss of Cish (show CISH Proteins) during pregnancy.

Pig (Porcine) Suppressor of Cytokine Signaling 2 (SOCS2) interaction partners

Cow (Bovine) Suppressor of Cytokine Signaling 2 (SOCS2) interaction partners

  1. hepatic growth hormone receptor (show GHR Proteins) and suppressor of cytokine signaling (SOCS (show CISH Proteins))2 messenger RNA expression appeared to be promptly and sensitively regulated by increased estradiol levels before ovulation of dairy heifers

  2. relative amount of suppressors of cytokine signaling-2 (SOCS-2)messenger RNA increased after parturition

SOCS2 Protein Profile

Protein Summary

This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with SOCS2

  • suppressor of cytokine signaling 2 (SOCS2)
  • suppressor of cytokine signaling 2 (socs2)
  • suppressor of cytokine signaling 2 (LOC100229201)
  • suppressor of cytokine signaling 2 (Socs2)
  • 8030460M17 protein
  • AI527257 protein
  • AW108012 protein
  • CIS2 protein
  • Cish2 protein
  • D130043N08Rik protein
  • hg protein
  • JAB protein
  • si:dkey-202b22.1 protein
  • Socs-2 protein
  • socs2 protein
  • SSI-2 protein
  • SSI2 protein
  • STATI2 protein

Protein level used designations for SOCS2

suppressor of cytokine signaling-2 , suppressor of cytokine signaling 2 , suppressor of cytokine signaling 2 variant 1 , CIS-2 , STAT induced STAT inhibitor-2 , STAT-induced STAT inhibitor 2 , STAT-induced STAT inhibitor-2 , cytokine-inducible SH2 protein 2 , cytokine inducible SH2-containing protein 2 , SOCS-2 , suppressor of cytokine signalling 2

452127 Pan troglodytes
562062 Danio rerio
100144308 Takifugu rubripes
100144375 Oryzias latipes
100190869 Gasterosteus aculeatus
100272211 Oncorhynchus mykiss
395219 Gallus gallus
100151723 Xenopus (Silurana) tropicalis
100229201 Taeniopygia guttata
8835 Homo sapiens
216233 Mus musculus
482603 Canis lupus familiaris
100037966 Sus scrofa
338437 Bos taurus
84607 Rattus norvegicus
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