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Human SOCS2 Protein expressed in Wheat germ - ABIN1320927
Sen, Peng, Woods, Wistuba, Bell, El-Naggar, Lai, Johnson: STAT5A-mediated SOCS2 expression regulates Jak2 and STAT3 activity following c-Src inhibition in head and neck squamous carcinoma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012
The upregulation of SOCS-1 (show SOCS1 Proteins) and SOCS-2 by cortisol may be playing a key role in suppressing cytokine signaling and the associated inflammatory response.
focus on SOCS2 and review its biological function as well as its implication in pathological processes
SOCS2 may improve outcome of TBI (show TBPL1 Proteins) in mice by regulating aspects of the neuroinflammatory response
This study showed that there was significantly increased levels of SOCS-2 mRNA in elderly and Alzheimer's disease brains.
crystals of SOCS2 in complex with its adaptor proteins, Elongin C (show TCEB1 Proteins) and Elongin B (show TCEB2 Proteins), underwent a change in crystallographic parameters when treated with dimethyl sulfoxide during soaking experiments.
miR (show MLXIP Proteins)-101 functions as a growth-suppressive miRNA in H. pylori related GC, and that its suppressive effects are mediated mainly by repressing SOCS2 expression.
our study indicates that high SOCS2 expression is associated with poor survival in pediatric AML (show RUNX1 Proteins).
This study shows that over-expression of SOCS2 reduces the psychostimulant effects of amphetamine, enhances PPI, and alters mesolimbic dopaminergic activity.
The SOCS2 polymorphism (rs3782415) has an influence on the adult height of children with Turner syndrome and growth hormone deficiency after long-term therapy.
SOCS2 correlates with malignancy and exerts growth-promoting effects in prostate cancer.
Stage-independent downregulation of SOCS2 and SOCS6 (show SOCS6 Proteins) correlate with disease-free survival in colorectal cancer.
Data (including data from studies in knockout mice) suggest Socs2 regulates liver regeneration rate after partial hepatectomy, Ghr (growth hormone receptor (show GHR Proteins)) level via ubiquitination/proteolysis, and serum Igf1 (insulin-like growth factor-1 (show IGF1 Proteins)) level.
GH appears to act directly on the metatarsals of Socs2(-/-) mice, promoting growth via a mechanism that is independent of IGF-1 (show IGF1 Proteins).
comparison of murine wt and Socs2(-/-) HSC (show FUT1 Proteins) gene expression in response to 5-FU revealed a significant overlap with the molecular programs that correlate with SOCS2 expression in leukemias, particularly with the oncogenic pathways
Studies indicate the critical role of suppressor of cytokine signaling 2 (SOCS2) in ontrolling the local growth hormone (GH (show GH1 Proteins)) anabolic bone effects.
Taken together, our observations indicated that SOCS2 could suppress myotube formation, act as an anti-regulator of mitochondria biogenesis via inhibiting p38 MAPK (show MAPK14 Proteins) signal pathway.
SOCS2 immunoprecipitates with TrkA (show NTRK1 Proteins) and a juxtamembrane motif of TrkA (show NTRK1 Proteins) is required for this interaction. Over-expression of SOCS2 in PC12 Tet-On cells increased total and surface TrkA (show NTRK1 Proteins) expression. SOCS2 regulates neurite outgrowth.
Results show that CISH (show CISH Proteins) has no non-redundant functions in beta cell proliferation or glucose homeostasis during pregnancy in mice. Socs2 might compensate for the loss of Cish (show CISH Proteins) during pregnancy.
SOCS2-mediated feedback regulation of the JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) pathway is deficient in BCR (show BCR Proteins)/ABL1 (show ABL1 Proteins)-induced chronic myeloid leukemia (show BCL11A Proteins).
SOCS2 plays a role in modulating heart damage and function in a murine model of acute Chagas disease.
This study identified SOCS2 as an important regulator of hepatic homeostasis under conditions of high-fat dietary stress.
hepatic growth hormone receptor (show GHR Proteins) and suppressor of cytokine signaling (SOCS (show CISH Proteins))2 messenger RNA expression appeared to be promptly and sensitively regulated by increased estradiol levels before ovulation of dairy heifers
relative amount of suppressors of cytokine signaling-2 (SOCS-2)messenger RNA increased after parturition
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants.
suppressor of cytokine signaling-2
, suppressor of cytokine signaling 2
, suppressor of cytokine signaling 2 variant 1
, STAT induced STAT inhibitor-2
, STAT-induced STAT inhibitor 2
, STAT-induced STAT inhibitor-2
, cytokine-inducible SH2 protein 2
, cytokine inducible SH2-containing protein 2
, suppressor of cytokine signalling 2