Browse our SOCS6 Proteins (SOCS6)

Full name:
Suppressor of Cytokine Signaling 6 Proteins (SOCS6)
On are 3 Suppressor of Cytokine Signaling 6 (SOCS6) Proteins from 2 different suppliers available. Additionally we are shipping SOCS6 Antibodies (52) and SOCS6 Kits (2) and many more products for this protein. A total of 63 SOCS6 products are currently listed.
1500012M23Rik, 5830401B18Rik, AI447482, CIS-4, Cis4, Cish4, HSPC060, MGC81477, SOCS-4, SOCS-6, Socs4, SOCS6, SSI4, STAI4, STATI4
list all proteins Gene Name GeneID UniProt
Rat SOCS6 SOCS6 307200  
SOCS6 9306 O14544
SOCS6 54607 Q9JLY0

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SOCS6 Proteins (SOCS6) by Origin

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More Proteins for SOCS6 Interaction Partners

Rainbow Trout (Oncorhynchus mykiss) Suppressor of Cytokine Signaling 6 (SOCS6) interaction partners

  1. Four new members of the SOCS (show CISH Proteins) family of molecules in rainbow trout (Oncorhynchus mykiss), CISH (show CISH Proteins) and SOCS6, 7 and 9, are described for the first time in this species

Human Suppressor of Cytokine Signaling 6 (SOCS6) interaction partners

  1. miR (show MLXIP Proteins)-142-3p regulates NPC (show NPC1 Proteins) development by down-regulating SOCS6 expression and suggest that modulation of miR (show MLXIP Proteins)-142-3p expression could be a therapeutic strategy for NPC (show NPC1 Proteins)

  2. Stage-independent downregulation of SOCS2 (show SOCS2 Proteins) and SOCS6 correlate with disease-free survival in colorectal cancer.

  3. Studied both the function of upregulated miR (show MLXIP Proteins)-424-5p in pancreatic cancer and how downstream suppressor of cytokine-induced signaling 6 (SOCS6) is negatively regulated by miR (show MLXIP Proteins)-424-5p.

  4. miR-17-5p might function as a pro-proliferative factor by repressing SOCS6 in gastric cancer

  5. SOCS2 (show SOCS2 Proteins) and SOCS6 expression are remarkably reduced in hepatocellular carcinoma and correlate with aggressive tumor progression and poor prognosis

  6. Results show that SOCS6 forms complex with DRP1 and the mitochondrial phosphatase PGAM5, attenuates DRP1 phosphorylation, and promotes DRP1 mitochondrial translocation.

  7. SOCS6 negatively regulates Flt3 (show FLT3 Proteins) activation, the downstream Erk (show EPHB2 Proteins) signaling pathway, and cell proliferation.

  8. Reduced copy number and mRNA expression of SOCS6 are associated with disease recurrence in primary lung squamous cell carcinoma and may be useful prognostic biomarkers.

  9. The results may contribute to understanding SOCS5 (show SOCS5 Proteins) and SOCS6 expression regulation in various cancer tissues, and show that these two factors may be used for diagnosing cancer.

  10. SOCS6 has ubiquitin ligase activity toward c-KIT

Mouse (Murine) Suppressor of Cytokine Signaling 6 (SOCS6) interaction partners

  1. Our results show that endogenous Cul5 (show CUL5 Proteins) suppresses epithelial cell transformation by several pathways, including inhibition of Src (show SRC Proteins)-Cas (show CTNND1 Proteins)-induced ruffling through SOCS6

  2. SOCS-6 binds to insulin receptor substrate 4 (show IRS4 Proteins), and mice lacking the SOCS-6 gene exhibit mild growth retardation(SOCS-6)

  3. SOCS4 expression, in contrast, does not appear to be EPO (show EPO Proteins) inducible.SOCS4 is ineffective at counteracting EPO (show EPO Proteins)-mediated events.

  4. SOCS6 has a role as a negative regulator of receptor tyrosine kinases

  5. SOCS-6 expression is induced by insulin, which regulates its binding to the p85 monomer of phosphoinositide 3-kinase

  6. TH1 (show HAND1 Proteins)-specific chromatin structure is created by early recruitment of Swi (show SMARCA1 Proteins)-SNF (show SNRPA Proteins) complexes and nucleosome remodeling dependent on Stat4 (show STAT4 Proteins).

SOCS6 Protein Profile

Protein Summary

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.

Alternative names and synonyms associated with SOCS6

  • suppressor of cytokine signaling 6 (Socs6)
  • suppressor of cytokine signaling 6 (SOCS6)
  • suppressor of cytokine signaling 6 (socs6)
  • suppressor of cytokine signaling (socs6)
  • 1500012M23Rik protein
  • 5830401B18Rik protein
  • AI447482 protein
  • CIS-4 protein
  • Cis4 protein
  • Cish4 protein
  • HSPC060 protein
  • MGC81477 protein
  • SOCS-4 protein
  • SOCS-6 protein
  • Socs4 protein
  • SOCS6 protein
  • SSI4 protein
  • STAI4 protein
  • STATI4 protein

Protein level used designations for SOCS6

suppressor of cytokine signaling 6 , suppressor of cytokine signaling , hypothetical protein LOC100124796 , STAT induced STAT inhibitor-4 , cytokine-inducible SH2 protein 4 , suppressor of cytokine signaling 4 , CIS-4 , SH2 domain containing SOCS box protein SOCS6 , cytokine inducible SH2-containing protein 4 , cytokine inducible SH2-containing protein CIS4 , SOCS-6

307200 Rattus norvegicus
421020 Gallus gallus
446567 Xenopus laevis
455521 Pan troglodytes
476171 Canis lupus familiaris
615146 Bos taurus
704108 Macaca mulatta
778986 Ciona intestinalis
100015445 Monodelphis domestica
100052089 Equus caballus
100124796 Xenopus (Silurana) tropicalis
100144310 Takifugu rubripes
100144377 Oryzias latipes
100155619 Sus scrofa
100344911 Oryctolagus cuniculus
100474949 Ailuropoda melanoleuca
100499596 Oncorhynchus mykiss
100526650 Bombyx mori
9306 Homo sapiens
54607 Mus musculus
100172146 Pongo abelii
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