anti-Monkey STAT3 antibody for Enzyme Immunoassay

Recommended STAT3 Antibody (supplied by: Log in to see )

Antigen
Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Antibodies
  • 1110034C02Rik
  • AW109958
  • Aprf
  • APRF
  • HIES
  • Xstat3
  • aprf
  • hies
  • stat3
  • wu:fc15d02
  • wu:fl59g06
  • z-Stat3
  • signal transducer and activator of transcription 3 (acute-phase response factor)
  • signal transduction and activation of transcription 3
  • signal transducer and activator of transcription 3
  • signal transducer and activator of transcription 3 (acute-phase response factor), gene 1
  • STAT3
  • stat3
  • Stat3
  • stat3.1
Reactivity
Human, Monkey, Mouse (Murine)
623
364
287
40
38
33
28
16
11
10
7
5
5
5
4
3
3
2
1
1
1
1
1
Host
Mouse
480
148
34
6
2
1
Clonality
Monoclonal
Conjugate
This STAT3 antibody is un-conjugated
28
24
20
14
12
11
10
7
5
5
5
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
561
244
229
93
87
84
74
59
27
12
11
9
8
6
5
4
3
3
3
2
2
2
2
1
1
1
1
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Catalog No. ABIN1109152
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1109150 EIA WB Rabbit IgG C-Term Log in to see Polyclonal

General

Antigen Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Antibodies
Reactivity Human, Monkey, Mouse (Murine)
(623), (364), (287), (40), (38), (33), (28), (16), (11), (10), (7), (5), (5), (5), (4), (3), (3), (2), (1), (1), (1), (1), (1)
Host Mouse
(480), (148), (34), (6), (2), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This STAT3 antibody is un-conjugated
(28), (24), (20), (14), (12), (11), (10), (7), (5), (5), (5), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(561), (244), (229), (93), (87), (84), (74), (59), (27), (12), (11), (9), (8), (6), (5), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Pubmed 2 references available
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Product Details anti-STAT3 Antibody

Target Details STAT3 Application Details Handling References for anti-STAT3 antibody (ABIN1109152) Images
Specificity Recognizes STAT3
Cross-Reactivity (Details) Species reactivity (tested):Human, Monkey, Mouse.
Purification Ascites
Clone 3B5
Isotype IgG1

Target Details STAT3

Product Details anti-STAT3 Antibody Application Details Handling References for anti-STAT3 antibody (ABIN1109152) Images back to top
Antigen
Alternative Name STAT3 (STAT3 Antibody Abstract)
Background The Stat3 transcription factor is an important signaling molecule for many cytokines and growth-factor receptors and is required for murine fetal development . Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation and DNA binding. Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways. Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3α (86 kDa) and Stat3β (79 kDa) depend on cell type, ligand exposure or cell maturation stage. It is notable that Stat3β lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain.Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.Synonyms: APRF, Acute-phase response factor, STAT-3, Signal transducer and activator of transcription 3
Molecular Weight 88 kDa
Gene ID 6774
Research Area Embryogenesis, Embryonic stem cells, Transcription Factors, Signaling, Receptors, Inflammation
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor

Application Details

Product Details anti-STAT3 Antibody Target Details STAT3 Handling References for anti-STAT3 antibody (ABIN1109152) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-STAT3 Antibody Target Details STAT3 Application Details References for anti-STAT3 antibody (ABIN1109152) Images back to top
Format Liquid

References for anti-STAT3 antibody (ABIN1109152)

Product Details anti-STAT3 Antibody Target Details STAT3 Application Details Handling Images back to top
Background publications

Schulze, Albers, Baranowsky, Keller, Spiro, Streichert, Zustin, Amling, Schinke: "Osteolytic prostate cancer cells induce the expression of specific cytokines in bone-forming osteoblasts through a Stat3/5-dependent mechanism." in: Bone, Vol. 46, Issue 2, pp. 524-33, 2010

Lin, Buettner, Yuan, Yip, Horne, Jove, Vaidehi: "Molecular dynamics simulations of the conformational changes in signal transducers and activators of transcription, Stat1 and Stat3." in: Journal of molecular graphics & modelling, Vol. 28, Issue 4, pp. 347-56, 2009

Images

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Supplier Images
Immunofluorescence (IF) image for anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) antibody (ABIN1109152) anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) antibody
Immunohistochemistry (IHC) image for anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) antibody (ABIN1109152) anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) antibody (Image 2)
Western Blotting (WB) image for anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) antibody (ABIN1109152) anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) antibody (Image 3)