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Browse our anti-TYK2 (TYK2) Antibodies

Full name:
anti-Tyrosine Kinase 2 Antibodies (TYK2)
On are 173 Tyrosine Kinase 2 (TYK2) Antibodies from 22 different suppliers available. Additionally we are shipping TYK2 Kits (16) and TYK2 Proteins (5) and many more products for this protein. A total of 201 TYK2 products are currently listed.
list all antibodies Gene Name GeneID UniProt
TYK2 7297 P29597
TYK2 54721  
TYK2 100361294  

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anti-Human TYK2 Antibodies:

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Top referenced anti-TYK2 Antibodies

  1. Human Monoclonal TYK2 Primary Antibody for IF, IP - ABIN967792 : Blesofsky, Mowen, Arduini, Baker, Murphy, Bowtell, David: Regulation of STAT protein synthesis by c-Cbl. in Oncogene 2001 (PubMed)
    Show all 5 references for ABIN967792

  2. Human Polyclonal TYK2 Primary Antibody for WB - ABIN319229 : Zheng, Hu, Quinn, Wang: Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography. in Molecular & cellular proteomics : MCP 2005 (PubMed)
    Show all 2 references for ABIN319229

  3. Human Polyclonal TYK2 Primary Antibody for IF, IHC - ABIN1533032 : Firmbach-Kraft, Byers, Shows, Dalla-Favera, Krolewski: tyk2, prototype of a novel class of non-receptor tyrosine kinase genes. in Oncogene 1990 (PubMed)
    Show all 2 references for ABIN1533032

  4. Human Monoclonal TYK2 Primary Antibody for ELISA, WB - ABIN969448 : Shaw, Freeman, Scott, Fox, Bzik, Belkaid, Yap: Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation. in Journal of immunology (Baltimore, Md. : 1950) 2006 (PubMed)
    Show all 2 references for ABIN969448

  5. Human Monoclonal TYK2 Primary Antibody for EIA, WB - ABIN1109416 : Seto, Nakajima, Suto, Shimoda, Saito, Nakayama, Iwamoto: Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice. in Journal of immunology (Baltimore, Md. : 1950) 2003 (PubMed)
    Show all 2 references for ABIN1109416

  6. Human Polyclonal TYK2 Primary Antibody for IHC (p) - ABIN197298 : Gauzzi, Velazquez, McKendry, Mogensen, Fellous, Pellegrini: Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. in The Journal of biological chemistry 1996 (PubMed)
    Show all 2 references for ABIN197298

More Antibodies against TYK2 Interaction Partners

Human Tyrosine Kinase 2 (TYK2) interaction partners

  1. demonstration of the single marker association of tyrosine kinase-2 polymorphisms with ulcerative colitis and Crohn's disease in Turkish population.

  2. The TYK2 promoter variant is associated with an overall risk for diabetes.

  3. Genetic associations and gene-gene interactions of IRF5 and TYK2 were significantly detected in Han Chinese with systemic lupus erythematosus

  4. the role of TYK2 in the pathogenesis of rheumatoid arthritis

  5. present findings suggest that TYK2 regulates apoptotic and proinflammatory pathways in pancreatic beta-cells via modulation of IFNalpha signaling, subsequent increase in MHC class I protein, and modulation of chemokines such as CXCL10 (show CXCL10 Antibodies).

  6. Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.

  7. Data indicate a chimeric fusion involving nucleophosmin NPM1 (show NPM1 Antibodies) (5q35) and TYK2 kinase (19p13) that encodes an NPM1 (show NPM1 Antibodies)-TYK2 protein in cutaneous CD30 (show TNFRSF8 Antibodies) antigen-positve lymphoproliferative disorders.

  8. the E3 ubiquitin ligase (show MUL1 Antibodies) seven-in-absentia-2 (SIAH2 (show SIAH2 Antibodies)) accelerates the proteasomal degradation of TYK which consequently suppresses the activation of STAT3 (show STAT3 Antibodies) in non-small-cell lung cancer

  9. Immune cell dysfunction may contribute to enhancement and maintenance of immune inflammatory and autoimmune responses by production of pathogenic cytokines and immune complexes. The role of Tyk2 in innate and adaptive immune cells is discussed. Review.

  10. In cellular assays, SAR (show SARDH Antibodies)-20347 dose dependently (1 nM-10 muM) inhibited JAK1 (show JAK1 Antibodies)- and/or TYK2-dependent signaling from the IL-12 (show IL12A Antibodies)/IL-23 (show IL23A Antibodies), IL-22 (show IL22 Antibodies), and IFN-alpha (show IFNA Antibodies) receptors.

Mouse (Murine) Tyrosine Kinase 2 (TYK2) interaction partners

  1. Decreased Tyk2 expression in pancreatic beta cells due to mutation determines susceptibility to virus-induced diabetes mellitus.

  2. Tyk2 protects against acute colitis in part by amplifying inflammation-induced epithelial IL-22 (show IL22 Antibodies) signaling to STAT3 (show STAT3 Antibodies)

  3. A reduced survival fitness of the Th17 in the absence of Tyk-2 mediated by the up-regulation of SOCS3 (show SOCS3 Antibodies).

  4. Data indicate the important role of Tyk2 in skin inflammation and the therapeutic potential of Tyk2 inhibition in psoriasis.

  5. The conditional Tyk2 mouse strain will be instrumental to further dissect TYK2 functions in infection, inflammation and cancer.

  6. In cellular assays, SAR (show SRL Antibodies)-20347 dose dependently (1 nM-10 muM) inhibited JAK1 (show JAK1 Antibodies)- and/or TYK2-dependent signaling from the IL-12 (show IL12A Antibodies)/IL-23 (show IL23A Antibodies), IL-22 (show IL22 Antibodies), and IFN-alpha (show IFNA Antibodies) receptors.

  7. this report identifies Tyk2 as a prerequisite factor in the molecular networks that are involved in generation of IL-27 (show IL27 Antibodies).

  8. Tyk2-mediated IL-12 (show IL12A Antibodies) signaling is differentially required for the development of different Th1 (show HAND1 Antibodies) cell subsets but similarly induces their bystander IFN-gamma (show IFNG Antibodies) production

  9. Expression of Tyk2 or the constitutively active form of the transcription factor Stat3 (show STAT3 Antibodies) (CAStat3) restores differentiation in Tyk2(-/-) brown preadipocytes.

  10. The first mouse Tyk2 crystal structures, which are complexed to 3-aminoindazole compounds, are described.

TYK2 Antigen Profile

Antigen Summary

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Alternative names and synonyms associated with TYK2

  • tyrosine kinase 2 (TYK2) antibody
  • tyrosine kinase 2 (Tyk2) antibody
  • tyrosine kinase 2-like (LOC100344622) antibody
  • JTK1 antibody

Protein level used designations for TYK2

non-receptor tyrosine-protein kinase TYK2 , tyrosine kinase TYK2 , non-receptor tyrosine kinase Tyk2

7297 Homo sapiens
54721 Mus musculus
100361294 Rattus norvegicus
430113 Gallus gallus
476714 Canis lupus familiaris
397363 Sus scrofa
512484 Bos taurus
100715734 Cavia porcellus
100344622 Oryctolagus cuniculus
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