TYK2 antibody (pTyr1054)

Catalog No. ABIN7138907

Product Details anti-TYK2 Antibody

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Binding Specificity: pTyr1054

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human, Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 1054 (H-E-Y(p)-Y-R) derived from Human TYK2.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TYK2

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Alternative Name: TYK2 (TYK2 Products)

Synonyms: JTK1 antibody, tyrosine kinase 2 antibody, TYK2 antibody, Tyk2 antibody

Background:

Background:

TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Zheng H, et al. (2005) Mol Cell Proteomics. 4(6):721-730.
Gauzzi MC, et al. (1996) J Biol Chem. 271(34): 20494-20500.

Aliases: JTK 1 antibody, JTK1 antibody, Non receptor tyrosine protein kinase 2 antibody, Non receptor tyrosine protein kinase TYK2 antibody, Non-receptor tyrosine-protein kinase TYK2 antibody, OTTHUMP00000232745 antibody, OTTHUMP00000232746 antibody, OTTHUMP00000232748 antibody, Protein Tyrosine Kinase 2 antibody, TYK 2 antibody, Tyk2 antibody, TYK2_HUMAN antibody, Tyrosine kinase 2 antibody

UniProt: P29597

Pathways: JAK-STAT Signaling, Hepatitis C