anti-Human TYK2 antibody for Enzyme Immunoassay

Recommended TYK2 Antibody (supplied by: Log in to see )

Antigen
Tyrosine Kinase 2 (TYK2) Antibodies
  • JTK1
  • tyrosine kinase 2
  • tyrosine kinase 2-like
  • TYK2
  • Tyk2
  • LOC100344622
Reactivity
Human
179
74
59
3
2
2
1
1
1
Host
Mouse
146
34
Clonality
Monoclonal
Conjugate
This TYK2 antibody is un-conjugated
7
7
7
5
5
5
2
2
2
2
2
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
108
72
66
27
27
24
13
10
2
1
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Catalog No. ABIN1109416
$ 434.50
Plus shipping costs $45.00

General

Antigen Tyrosine Kinase 2 (TYK2) Antibodies
Reactivity Human
(179), (74), (59), (3), (2), (2), (1), (1), (1)
Host Mouse
(146), (34)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TYK2 antibody is un-conjugated
(7), (7), (7), (5), (5), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Enzyme Immunoassay (EIA), Western Blotting (WB)
(108), (72), (66), (27), (27), (24), (13), (10), (2), (1)
Pubmed 2 references available
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Product Details anti-TYK2 Antibody

Target Details TYK2 Application Details Handling ProductDetails: References for anti-TYK2 antibody (ABIN1109416) Images
Specificity Recognizes Tyk2 (tyrosine kinase 2)
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Clone 8G8E9
Isotype IgG1

Target Details TYK2

Product Details anti-TYK2 Antibody Application Details Handling ProductDetails: References for anti-TYK2 antibody (ABIN1109416) Images back to top
Antigen
Alternative Name TYK2 (TYK2 Antibody Abstract)
Background Tyk2 (tyrosine kinase 2),with 1187-amino acid protein (about 131 kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-alpha, IFN-beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance.Synonyms: JTK1, Non-receptor tyrosine-protein kinase TYK2
Gene ID 7297
Research Area Signaling, Tyrosine Kinases
Pathways JAK-STAT Signaling, Hepatitis C

Application Details

Product Details anti-TYK2 Antibody Target Details TYK2 Handling ProductDetails: References for anti-TYK2 antibody (ABIN1109416) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-TYK2 Antibody Target Details TYK2 Application Details ProductDetails: References for anti-TYK2 antibody (ABIN1109416) Images back to top
Format Liquid
Buffer 0.03 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

ProductDetails: References for anti-TYK2 antibody (ABIN1109416)

Product Details anti-TYK2 Antibody Target Details TYK2 Application Details Handling Images back to top
Background publications

Shaw, Freeman, Scott, Fox, Bzik, Belkaid, Yap: "Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 12, pp. 7263-71, 2006

Seto, Nakajima, Suto, Shimoda, Saito, Nakayama, Iwamoto: "Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 2, pp. 1077-83, 2003

Images

Product Details anti-TYK2 Antibody Target Details TYK2 Application Details Handling ProductDetails: References for anti-TYK2 antibody (ABIN1109416) back to top
Supplier Images
Western Blotting (WB) image for anti-Tyrosine Kinase 2 (TYK2) antibody (ABIN1109416) anti-Tyrosine Kinase 2 (TYK2) antibody