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Results provide evidence that CDCA1 plays a significant role in oral cavity carcinoma (OCC) tumorigenesis. Importantly, CDCA1 is associated with growth and survival of OCC cells where its elevated expression issignificantly associated with poor prognosis .
NUF2 modulates cell proliferation via cell cycle control in osteosarcoma Saos-2 cells.
found LncRNA AF339813 was positively regulated by NUF2
NUF2 silencing by RANi (RNA interference) reduced the proliferation and colony formation ability of pancreatic cancer cells in vitro.
NUF2 plays a critical role in the regulation of HCC (show FAM126A ELISA Kits) cell proliferation and apoptosis.
NUF2 was overexpressed in glioma tissues and differentially expressed in a series of glioma cell lines. Depletion of NUF2 by short-hairpin RNA inhibited cell growth in vitro and in vivo.
hnRNP K binds to the promoter region of NUF2 and activates its transcription.
These results suggest that CDCA1 could be a prognostic biomarker and a potential therapeutic target for colorectal cancers .
these findings demonstrated that three buried glutamic acid-lysine pairs, in concert with hydrophobic interactions of core residues, provide the major specificity and stability requirements for Hec1-Nuf2 dimerization
NDC80 (show NDC80 ELISA Kits), NUF2 and PTN (show PTN ELISA Kits) were significantly aberrantly overexpressed in serous adenocarcinomas.
Nuf2 is a critical regulator of meiotic cell cycle progression in mammalian oocytes.
This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described.
NUF2, NDC80 kinetochore complex component, homolog
, cancer/testis antigen 106
, cell division cycle associated 1
, cell division cycle-associated protein 1
, kinetochore protein Nuf2
, un-named hi2769
, unm hi2769