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Data suggest that UBR5 (show UBR5 ELISA Kits) down-regulates levels of TRAF3 (show TRAF3 ELISA Kits), a key component of Toll (show TLR4 ELISA Kits)-like receptor signaling, via the miRNA pathway; p90RSK is an upstream regulator of UBR5 (show UBR5 ELISA Kits); p90RSK phosphorylates UBR5 (show UBR5 ELISA Kits) as required for translational repression of TRAF3 (show TRAF3 ELISA Kits) mRNA. (UBR5 (show UBR5 ELISA Kits) = ubiquitin protein ligase E3 component n-recognin 5 (show UBR5 ELISA Kits) protein; TRAF3 (show TRAF3 ELISA Kits) = TNF receptor-associated factor 3 (show TRAF3 ELISA Kits); p90RSK = 90 kDa ribosomal protein S6 (show RPS6 ELISA Kits) kinase (show RPS6KB1 ELISA Kits))
Data indicate that BTG2 (show BTG2 ELISA Kits), MAP3K11 (show MAP3K11 ELISA Kits), RPS6KA1 and PRDM1 (show PRDM1 ELISA Kits) as putative targets of microRNA miR (show MLXIP ELISA Kits)-125b.
VEGF-A (show VEGFA ELISA Kits) driven Mdm2 (show MDM2 ELISA Kits) phosphorylation on Ser166 is dependent on the ERK1/2 (show MAPK1/3 ELISA Kits)/p90RSK signaling pathway in primary human endothelial cells.
The p90RSK has an essential role in promoting tumor growth and proliferation in non-small cell lung cancer (NSCLC). BID (show BID ELISA Kits) may serve as an alternative cancer treatment in NSCLC.
RSK1 binds to EBP50 (show SLC9A3R1 ELISA Kits) at its first PDZ domain (show INADL ELISA Kits), and mitogen activated RSK1 phosphorylates EBP50 (show SLC9A3R1 ELISA Kits) at T156, an event that is crucial for its nuclear localization
Data show that the 90 kDa ribosomal protein S6 (show RPS6 ELISA Kits) kinases RSK1 and RSK2 (show RPS6KA3 ELISA Kits) play a key role in the homing of ovarian cancer cells in metastatic sites by regulating cell adhesion and invasion.
RSK1 and 3 but not RSK2 (show RPS6KA3 ELISA Kits) are down-regulated in breast tumour and are associated with disease progression. RSK may be a key component in the progression and metastasis of breast cancer.
PKD2 (show PKD2 ELISA Kits) and RSK1 regulate integrin beta4 phosphorylation at threonine 1736 to stabilize keratinocyte cell adhesion and its hemidesmosomes.
Results indicate that the phosphorylation of EphA2 (show EPHA2 ELISA Kits) at Ser (show SIGLEC1 ELISA Kits)-897 is controlled by RSK and the RSK-EphA2 (show EPHA2 ELISA Kits) axis might contribute to cell motility and promote tumour malignant progression.
SL0101 and BI-D1870 induce distinct off-target effects in mTORC1-p70S6K (show RPS6KB1 ELISA Kits) signaling, and thus, the functions previously ascribed to RSK1/2 based on these inhibitors should be reassessed.
In hippocampal neurons of wild-type mice, pP90RSK translocates into the nucleus upon stimulation with forskolin (left), whereas in Period1-knockout (Per1 (show PER1 ELISA Kits)(-/-) ) mice (right) the kinase is trapped at the nuclear periphery
Data show that the phosphoinositide-dependent kinase 1 (PDK1 (show PDPK1 ELISA Kits))-p90 (show GPAM ELISA Kits) kDa ribosomal S6 kinases (Rsks) Rsk1/2 pathway is critical for establishment and maintenance of a normal Langerhans cells (LC) network.
IL-6 (show IL6 ELISA Kits) induces the activation of the Stat3 (show STAT3 ELISA Kits) signaling and promotes the downmodulation of the p90RSK/eEF2 (show EEF2 ELISA Kits) and mTOR (show FRAP1 ELISA Kits)/p70S6K (show RPS6KB1 ELISA Kits) axes, while it does not affect the activation of AKT (show AKT1 ELISA Kits).
analysis of p38 (show CRK ELISA Kits)-MK2 (show KCNA2 ELISA Kits)-activated Rsk signaling in toll (show TLR4 ELISA Kits)-like receptor-stimulated dendritic cells
These data indicate that aripiprazole and quetiapine signal to specific nuclear targets of ERK (show EPHB2 ELISA Kits), which for quetiapine occurs via an EGFR (show EGFR ELISA Kits)-linked mechanism, possibly indicating involvement of this system in its action.
hypoxia/reoxygenation (H/R)-mediated decrease in PKARIalpha protein levels leads to activation of RSK1, which via phosphorylation of NHE1 (show SLC9A1 ELISA Kits) induces cardiomyocyte apoptosis.
RSK1 Cys223 glutathionylation may contribute to regulate the levels of nitric in the brain.
Our study highlights the importance of the p90RSK/ERK5 (show MAPK7 ELISA Kits) module as a critical mediator of endothelial dysfunction in diabetes mellitus and atherosclerosis formation.
Results show increased protein levels of Rsk1 and Rsk2 (show RPS6KA3 ELISA Kits) in the striatum of Huntington disease (show HTT ELISA Kits) mice and and striatal cells transfected with full-length mutant Huntingtin (show HTT ELISA Kits).
Type I keratin (show KRT12 ELISA Kits) 17 (show KRT17 ELISA Kits) protein is phosphorylated on serine 44 by p90 (show GPAM ELISA Kits) ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
90 kDa ribosomal protein S6 kinase 1
, MAP kinase-activated protein kinase 1a
, MAPK-activated protein kinase 1a
, MAPKAP kinase 1a
, S6K-alpha 1
, dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)
, p90-RSK 1
, ribosomal S6 kinase 1
, ribosomal protein S6 kinase alpha 1
, ribosomal protein S6 kinase alpha-1
, ribosomal protein S6 kinase, 90kD, polypeptide 1; Ribosomal protein S6 kinase, 90kD, 1
, MAP kinase-activated protein kinase 1
, MAPK-activated protein kinase 1
, MAPKAP kinase 1
, ribosomal protein S6 kinase 2 alpha
, ribosomal protein S6 kinase II alpha
, S6 protein kinase (Rsk-1)
, S6 kinase II beta
, ribosomal protein S6 kinase 2 beta
, ribosomal protein S6 kinase II beta
, ribosomal protein S6 kinase a, polypeptide 1