anti-Monkey SIRT1 antibody for Enzyme Immunoassay

Recommended SIRT1 Antibody (supplied by: Log in to see )

Antigen
Sirtuin 1 (SIRT1) Antibodies
  • sirtuin 1
  • AA673258
  • SIR2L1
  • Sir2
  • Sir2a
  • Sir2alpha
  • sir2l1
  • sirtuin
  • SIR2
  • sirtuin 1
  • SIRT1
  • SRT1
  • LOC100349271
  • Sirt1
  • sirt1
Reactivity
Human, Monkey
306
138
70
21
13
11
7
7
7
6
5
4
4
2
2
2
2
1
Host
Mouse
206
86
27
6
3
Clonality
Monoclonal
Conjugate
This SIRT1 antibody is un-conjugated
17
14
10
7
7
6
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
255
132
88
66
60
51
41
40
36
7
5
5
4
2
2
2
2
2
1
1
Supplier
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Catalog No. ABIN1109014
$ 390.50
Plus shipping costs $45.00

General

Antigen Sirtuin 1 (SIRT1) Antibodies
Reactivity Human, Monkey
(306), (138), (70), (21), (13), (11), (7), (7), (7), (6), (5), (4), (4), (2), (2), (2), (2), (1)
Host Mouse
(206), (86), (27), (6), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This SIRT1 antibody is un-conjugated
(17), (14), (10), (7), (7), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1)
Application Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(255), (132), (88), (66), (60), (51), (41), (40), (36), (7), (5), (5), (4), (2), (2), (2), (2), (2), (1), (1)
Pubmed 2 references available
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Product Details anti-SIRT1 Antibody

Target Details SIRT1 Application Details Handling ProductDetails: References for anti-SIRT1 antibody (ABIN1109014) Images
Specificity Recognizes SIRT1
Cross-Reactivity (Details) Species reactivity (tested):Human, Monkey.
Purification Ascites
Clone 1F3
Isotype IgG1

Target Details SIRT1

Product Details anti-SIRT1 Antibody Application Details Handling ProductDetails: References for anti-SIRT1 antibody (ABIN1109014) Images back to top
Antigen
Alternative Name SIRT1 (SIRT1 Antibody Abstract)
Background The Sir2 protein in yeast is known to function in transcriptional silencing processes through the deacetylation of histones H3 and H4. The more recently described human homologue of Sir2, known as SIRT1, has been found to associate with the tumor suppressor protein p53.SIRT1 binds and deacetylates p53 with specificity for its C-terminal Lys382 residue in response to the upregulation of promyelocytic leukemia protein (PML) nuclear bodies or oncogenic Ras. The deacetylation of p53 SIRT1 has been shown to negatively regulate p53-mediated transcription, preventing cellular senescence and apoptosis induced by DNA damage and stress.SIRT1 has the closest homology to the yeast Sir2p and is widely expressed in fetal and adult tissues, with high expression in heart, brain and skeletal muscle and low expression in lung and placenta. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically at Lysine 382.Synonyms: NAD-dependent deacetylase sirtuin-1, S. cerevisiae, SIR2-like protein 1, SIR2L1, SIR2alpha, SIRT-1, homolog) 1, sirtuin (silent mating type information regulation 2, sirtuin 1, sirtuin type 1, sirtuin-1
Molecular Weight 120 kDa
Gene ID 23411
Research Area Chromatin and Nuclear Signaling, Apoptosis/Necrosis, Proteases
Pathways MAPK Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Negative Regulation of intrinsic apoptotic Signaling

Application Details

Product Details anti-SIRT1 Antibody Target Details SIRT1 Handling ProductDetails: References for anti-SIRT1 antibody (ABIN1109014) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-SIRT1 Antibody Target Details SIRT1 Application Details ProductDetails: References for anti-SIRT1 antibody (ABIN1109014) Images back to top
Format Liquid

ProductDetails: References for anti-SIRT1 antibody (ABIN1109014)

Product Details anti-SIRT1 Antibody Target Details SIRT1 Application Details Handling Images back to top
Background publications

Sowa, Bennett, Gygi, Harper: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009

Xie, Park, Kim, Hwang, Oh, Park, Shong, Lee, Choi: "Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 28762-74, 2009

Images

Product Details anti-SIRT1 Antibody Target Details SIRT1 Application Details Handling ProductDetails: References for anti-SIRT1 antibody (ABIN1109014) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-Sirtuin 1 (SIRT1) antibody (ABIN1109014) anti-Sirtuin 1 (SIRT1) antibody
Western Blotting (WB) image for anti-Sirtuin 1 (SIRT1) antibody (ABIN1109014) anti-Sirtuin 1 (SIRT1) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-Sirtuin 1 (SIRT1) antibody (ABIN1109014) anti-Sirtuin 1 (SIRT1) antibody (Image 3)
Immunofluorescence (IF) image for anti-Sirtuin 1 (SIRT1) antibody (ABIN1109014) anti-Sirtuin 1 (SIRT1) antibody (Image 4)