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Browse our anti-LRP2 (LRP2) Antibodies

Full name:
anti-Low Density Lipoprotein Receptor-Related Protein 2 Antibodies (LRP2)
On www.antibodies-online.com are 61 Low Density Lipoprotein Receptor-Related Protein 2 (LRP2) Antibodies from 16 different suppliers available. Additionally we are shipping LRP2 Kits (15) and LRP2 Proteins (7) and many more products for this protein. A total of 83 LRP2 products are currently listed.
Synonyms:
AI315343, AW536255, D230004K18Rik, DBS, Gp330, im:680590, lrp2, Megalin

Most Popular Reactivities for anti-LRP2 (LRP2) Antibodies

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anti-Human LRP2 Antibodies:

anti-Mouse (Murine) LRP2 Antibodies:

anti-Rat (Rattus) LRP2 Antibodies:

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Top referenced anti-LRP2 Antibodies

  1. Human Monoclonal LRP2 Primary Antibody for IF, IHC (p) - ABIN360955 : Saito, Yamazaki, Rader, Nakatani, Ullrich, Kerjaschki, Orlando, Farquhar: Mapping rat megalin: the second cluster of ligand binding repeats contains a 46-amino acid pathogenic epitope involved in the formation of immune deposits in Heymann nephritis. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)
    Show all 6 references for ABIN360955

  2. Human Monoclonal LRP2 Primary Antibody for ICC, IHC (fro) - ABIN410077 : Chang, Ohse, Krofft, Wu, Eddy, Pippin, Shankland: Albumin-induced apoptosis of glomerular parietal epithelial cells is modulated by extracellular signal-regulated kinase 1/2. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012 (PubMed)
    Show all 6 references for ABIN410077

  3. Human Polyclonal LRP2 Primary Antibody for IF (p), IHC (p) - ABIN750988 : Jayachandran, Lugo, Heiling, Miller, Rule, Lieske: Extracellular vesicles in urine of women with but not without kidney stones manifest patterns similar to men: a case control study. in Biology of sex differences 2015 (PubMed)
    Show all 2 references for ABIN750988

  4. Human Polyclonal LRP2 Primary Antibody for IHC (p), IHC - ABIN315066 : Thelen, Abouhamed, Ciarimboli, Edemir, Bähler: Rho GAP myosin IXa is a regulator of kidney tubule function. in American journal of physiology. Renal physiology 2015 (PubMed)

  5. Human Polyclonal LRP2 Primary Antibody for IHC, IHC (p) - ABIN4331524 : Ma, Corsa, Zhou, Yang, Li, Tang, Babaev, Major, Linton, Fazio, Hunley, Kon, Fogo: Angiotensin type 1 receptor modulates macrophage polarization and renal injury in obesity. in American journal of physiology. Renal physiology 2011 (PubMed)

More Antibodies against LRP2 Interaction Partners

Zebrafish Low Density Lipoprotein Receptor-Related Protein 2 (LRP2) interaction partners

  1. Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development.

  2. These studies implicate altered Lrp2-mediated homeostasis as important for myopia and other risk factors for glaucoma.

Rabbit Low Density Lipoprotein Receptor-Related Protein 2 (LRP2) interaction partners

  1. Megalin mediates transepithelial albumin (show ALB Antibodies) clearance from the alveolar space of intact rabbit lungs

  2. low-level LPS (show IRF6 Antibodies)-mediated TNF-alpha (show TNF Antibodies)-ERK1/2 (show MAPK1/3 Antibodies) signaling pathway is involved in downregulation of megalin expression in IRPTCs.

Human Low Density Lipoprotein Receptor-Related Protein 2 (LRP2) interaction partners

  1. VDR (show CYP27B1 Antibodies) and MEGALIN gene variations can alter age-related cognitive trajectories differentially between men and women among African American urban adults, specifically in global mental status and domains of verbal fluency, visual/working memory, and executive function.

  2. the main role for placental megalin is not to mediate uptake of nutrients from the maternal bloodstream; results point toward novel and complex functions for megalin in the cytotrophoblasts.

  3. specific miRNA-146a regulation may contribute to Alzheimer's disease by downregulating the Lrp2/Akt (show AKT1 Antibodies) pathway

  4. abundances of megalin and Dab2 (show DAB2 Antibodies) (p = 0.046) were reduced in infected placentas from women with LBW deliveries

  5. homozygous Asp3779Asn and a hemizygous Ile262Met mutations in the LRP2 and TSPYL2 (show TSPYL2 Antibodies) genes, respectively, in a Pakistani family with two boys affected with mild nonsyndromic intellectual disability

  6. The megalin expression appears to vary inversely with gestational age with the greatest expression noted in the most premature samples. Age-dependent differences in placental megalin may therefore influence fetal exposure.

  7. we are the first to identify the association between LRP2 and gout in a Chinese population and to confirm this association in Asians.

  8. Two novel LRP2 mutations, a homozygous nonsense mutation and a missense mutation in two unrealted families with Donnai-Barrow syndrome.

  9. Loss of LRP2 is associated with buphthalmos

  10. melanoma cell expression of LRP2/megalin significantly decreases melanoma cell proliferation and survival rates.

Mouse (Murine) Low Density Lipoprotein Receptor-Related Protein 2 (LRP2) interaction partners

  1. study reveals a cross talk between ATR (show ATR Antibodies) signaling and DPP4 (show DPP4 Antibodies) activation in the regulation of megalin and underscores the significance of targeting DPP4 (show DPP4 Antibodies) in the prevention of obesity related kidney injury progression.

  2. LRP2 plays a crucial role in cardiovascular development in mice.

  3. Foxg1 (show FOXG1 Antibodies)-Cre mediated Lrp2 inactivation in developing mouse neural retina, ciliary and retinal pigment epithelia is a model of congenital high myopia

  4. megalin-deficient mice may provide a valuable model for future studies of megalin in ocular physiology and pathology.

  5. LRP2 is essential for cellular folate uptake in the developing neural tube, a crucial step for proper neural tube closure.

  6. we have identified hypothalamic clusterin (show CLU Antibodies) as a novel anorexigenic molecule that can potentiate central leptin (show LEP Antibodies) activity.

  7. Multiligand endocytic receptor megalin may be involved in AT1a (show AGTR1a Antibodies) receptor-mediated uptake of angiotensin II by proximal tubule cells.

  8. SNPs in the CYP24A1 (show CYP24A1 Antibodies), CYP2R1 (show CYP2R1 Antibodies), calcium sensing receptor (CASR (show CASR Antibodies)), vitamin D binding protein (GC (show GC Antibodies)), retinoid X receptor-alpha (RXRA (show RXRA Antibodies)) and megalin (LRP2) genes were significantly associated with pancreas cancer risk.

  9. Lrp2 is a novel target gene by progesterone and progesterone receptor (show PGR Antibodies).

  10. The hypothalamic clusterin (show CLU Antibodies)-low-density lipoprotein receptor-related protein-2 axis is a novel anorexigenic signalling pathway.

LRP2 Antigen Profile

Antigen Summary

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling\; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).

Alternative names and synonyms associated with LRP2

  • low density lipoprotein receptor-related protein 2 (LRP2) antibody
  • low density lipoprotein receptor-related protein 2a (lrp2a) antibody
  • low-density lipoprotein receptor-related protein 2 (LRP2.3) antibody
  • low density lipoprotein receptor-related protein 2 (lrp2) antibody
  • low-density lipoprotein receptor-related protein 2-like (LOC100183506) antibody
  • low density lipoprotein receptor-related protein 2 (Lrp2) antibody
  • AI315343 antibody
  • AW536255 antibody
  • D230004K18Rik antibody
  • DBS antibody
  • Gp330 antibody
  • im:680590 antibody
  • lrp2 antibody
  • Megalin antibody

Protein level used designations for LRP2

low density lipoprotein-related protein 2 , gp330b , low-density lipoprotein receptor-related protein 2 , megalin , low density lipoprotein receptor-related protein 2 , low-density lipoprotein receptor-related protein 2-like , Heymann nephritis antigen homolog , LRP-2 , calcium sensor protein , glycoprotein 330 , gp330

GENE ID SPECIES
459713 Pan troglodytes
478781 Canis lupus familiaris
568184 Danio rerio
589778 Strongylocentrotus purpuratus
7232953 Branchiostoma floridae
100024150 Monodelphis domestica
100062836 Equus caballus
100126618 Xenopus laevis
100183506 Ciona intestinalis
100346275 Oryctolagus cuniculus
100403066 Callithrix jacchus
100455598 Pongo abelii
100475386 Ailuropoda melanoleuca
100489914 Xenopus (Silurana) tropicalis
100543626 Meleagris gallopavo
100558696 Anolis carolinensis
100591561 Nomascus leucogenys
4036 Homo sapiens
14725 Mus musculus
29216 Rattus norvegicus
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