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Human Monoclonal GABPA Primary Antibody for ICC, ELISA - ABIN969163
Batchelor, Piper, de la Brousse, McKnight, Wolberger: The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA. in Science (New York, N.Y.) 1998
Show all 3 Pubmed References
Human Polyclonal GABPA Primary Antibody for ICC, IF - ABIN4313121
Sharma, Massie, Butter, Mann, Bon, Ramos-Montoya, Menon, Stark, Lamb, Scott, Warren, Neal, Mills: The ETS family member GABP? modulates androgen receptor signalling and mediates an aggressive phenotype in prostate cancer. in Nucleic acids research 2014
Human Polyclonal GABPA Primary Antibody for IF (p), IHC (p) - ABIN1714176
Chang, Wu, Xu, Liao, Wu, Cheng: Scopoletin Protects against Methylglyoxal-Induced Hyperglycemia and Insulin Resistance Mediated by Suppression of Advanced Glycation Endproducts (AGEs) Generation and Anti-Glycation. in Molecules (Basel, Switzerland) 2015
CRISPR-mediated reversal of mutant TERT (show TERT Antibodies) promoters, or deletion of its long-range interacting chromatin, abrogates GABPA binding and long-range interactions, leading to depletion of active histone marks, loss of POL2 recruitment, and suppression of TERT (show TERT Antibodies) transcription
potential mechanism of TERT (show TERT Antibodies) reactivation mediated by a novel long-range chromatin interaction between the TERT (show TERT Antibodies) promoter on chromosome 5p and a 300-kb upstream region. This permits recruitment of the transcription factor GABPA in mutant TERT (show TERT Antibodies) promoters but not in wild-type promoters.
a key role for GABPA/B1 as the critical ETS (show ETS1 Antibodies) transcription factors deregulating SDHD (show SDHD Antibodies) expression in the context of highly recurrent promoter mutations in melanoma.
Analyses of data sets link GABPa to cognitive disorders, diabetes, KRAB zinc finger (KRAB-ZNF (show ZNF629 Antibodies)), and human-specific genes.
ELF1 (show EFNA2 Antibodies) binding occurs at both TERT (show TERT Antibodies) promoter mutations in melanoma in vitro such that increased recruitment of GABP is enabled by the spatial architecture of native and novel ETS (show ETS1 Antibodies) motifs in the TERT (show TERT Antibodies) promoter region.
The results suggest that NRF-2alpha is a regulator of SIRT3 (show SIRT3 Antibodies) expression and may shed light on how SIRT3 (show SIRT3 Antibodies) is upregulated during nutrient stress.
GABPalpha Binding to Overlapping ETS (show ETS1 Antibodies) and CRE DNA Motifs Is Enhanced by CREB1 (show CREB1 Antibodies)
Expression of the ETS transcription factor (show FEV Antibodies) GABPalpha is positively correlated to the BCR (show BCR Antibodies)-ABL1/ABL1 (show ABL1 Antibodies) ratio in CML (show BCR Antibodies) patients and affects imatinib sensitivity in vitro.
study supports the crucial role of GABP in myeloid cell differentiation and identified ITGAM/CD11b (show ITGAM Antibodies) as a novel GABP target gene
GABPA thus directly links TERT (show TERT Antibodies) promoter mutations to aberrant expression in multiple cancers.
conditionally deleted Gabpa, the DNA-binding component of this transcription factor complex, from embryonic fibroblasts to examine the role of Gabp in mitochondrial biogenesis, function, and gene expression
Loss of Gabpalpha prevented development of CML, although mice continued to generate BCR-ABL (show ABL1 Antibodies)-expressing Gabpalpha-null cells for months that were serially transplantable and contributed to all lineages in secondary recipients.
NRF-2 (show NFE2L2 Antibodies) and NRF-1 (show NRF1 Antibodies) operate in a concurrent and parallel manner in mediating the tight coupling between energy metabolism and neuronal activity at the molecular level.
Through genome-wide mapping of GABPalpha binding and transcriptomic analysis of GABPalpha-deficient HSCs, we identified Zfx (show ZFX Antibodies) and Etv6 (show ETV6 Antibodies) transcription factors and prosurvival Bcl-2 (show BCL2 Antibodies) family members including Bcl-2 (show BCL2 Antibodies), Bcl-X(L (show BCL2L1 Antibodies)), and Mcl-1 (show MCL1 Antibodies) as direct GABP target genes.
Disruption of Gabpa was associated with a marked reduction in myeloid progenitor cells, and Gabpalpha null myeloid cells express reduced levels of the transcriptional repressor, Gfi-1.
chemical shift and secondary structure of the PNT (show ETS2 Antibodies)/SAM (show TTN Antibodies) domains
Erralpha (show ESRRA Antibodies) and GA-binding protein a (show GPR153 Antibodies) partner with PGC-1alpha (show PPARGC1A Antibodies) in muscle to form a double-positive-feedback loop that drives the expression of many oxidative phosphorylation genes
Gabpa function is essential and is not compensated for by other ETS (show ETS1 Antibodies) transcription factors and is consistent with a specific requirement for Gabp expression for the maintenance of target genes involved in embryo essential mitochondrial cellular functions
GABP is essential for the regulation of IL-7Ralpha (show IL7R Antibodies) expression in T cells.
This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene.
GA binding protein transcription factor, alpha subunit 60kDa
, transcription factor GABP alpha subunit
, GA binding protein transcription factor, alpha subunit (60kD)
, GA-binding protein alpha chain-like
, GA repeat binding protein, alpha
, GA-binding protein alpha chain
, nuclear respiratory factor 2 alpha
, GA binding protein transcription factor alpha subunit 60kDa
, GABP subunit alpha
, human nuclear respiratory factor-2 subunit alpha
, nuclear respiratory factor 2 alpha subunit
, nuclear respiratory factor 2 subunit alpha
, transcription factor E4TF1-60
, GA repeat binding protein alpha
, GA-binding protein alpha-subunit
, E4tf1-60 transcription factor