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anti-Human IGFBP3 Antibodies:
anti-Mouse (Murine) IGFBP3 Antibodies:
anti-Rat (Rattus) IGFBP3 Antibodies:
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Human Monoclonal IGFBP3 Primary Antibody for IF, WB - ABIN968565
Campbell, Durham, Hayes, Suwanichkul, Powell: Insulin-like growth factor-binding protein-3 binds fibrinogen and fibrin. in The Journal of biological chemistry 1999
Show all 5 Pubmed References
Human Polyclonal IGFBP3 Primary Antibody for IHC (p), WB - ABIN3044421
Pu, Zheng, Zhang, Xiao, Xu, Liu, Wang, Wen, Zhou, Wu: Higher expression of mRNA and protein of insulin-like growth factor binding protein-3 in old rat penile tissues: implications for erectile dysfunction. in The journal of sexual medicine 2011
Show all 2 Pubmed References
Human Polyclonal IGFBP3 Primary Antibody for IHC (p), ELISA - ABIN3043859
Pu, Wen, Liu, Zheng, Xiao, Xu, Wang, Li, Zhang: shRNA constructs targeting IGFBP-3 alleviate age related erectile dysfunction in the rat. in The Journal of urology 2014
Show all 2 Pubmed References
Human Polyclonal IGFBP3 Primary Antibody for ELISA, WB - ABIN314305
Lin, Manson, Lee, Cook, Buring, Zhang: Intakes of calcium and vitamin D and breast cancer risk in women. in Archives of internal medicine 2007
Human Polyclonal IGFBP3 Primary Antibody for IF (p), IHC (p) - ABIN686497
Yuan, Han, Cong, Ge, Ma, Dai, Li, Bi: Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity. in International journal of nanomedicine 2014
insulin-like growth factor binding protein 3 exerts its ligand-independent action by antagonizing bone morphogenetic protein 2 (show BMP4 Antibodies) in zebrafish embryos
IGFBP-3 plays an important role in regulating pharyngeal cartilage and inner ear development and growth in zebrafish.
our results reveal a new function of IGFBP2 (show IGFBP2 Antibodies), providing a novel insight into the mechanism of adipogenic differentiation and identifying a potential target mediator for improving adipose tissue engineering based on Wharton's jelly of the umbilical cord (WJCMSCs).
Increased IGFBP3 level as associated with decreased risk of frailty in men.
Report serum IGF1 (show IGF1 Antibodies)/IGFBP3 levels in relation to clinical/pathobiological features of squamous cell carcinomas of the head and neck.
Functional IGFBP-3 was significantly lower in postmenopausal women than in premenopausal women, for both patients with rheumatoid arthritis and controls. There was a significant decrease in plasma functional IGFBP-3 levels in postmenopausal RA in comparison to healthy premenopausal subjects.
study suggests high-order interactions of the IGFBP-3 rs2854744 AA genotype, BMI>/=24kg/m2, and DISI<9.85 mg/day on increased BC risk, particularly among postmenopausal women
IGFBP2 (show IGFBP2 Antibodies) and IGFBP3 may serve as compensatory biomarkers for CA19-9. Early diagnosis with this marker combination may improve the prognosis of invasive ductal adenocarcinoma of pancreas patients.
The stratification of individuals by gender revealed that Slovak males carrying IGFBP-3 G alleles (G32G or GG) had marginally increased risk for developing MDD as compared to CC homozygous males (p=0.09). In women, inverse association was observed between SNP rs1042522 and MDD risk (p=0.04 for recessive model).
this study identified several loci associated with circulating IGF-I (show IGF1 Antibodies) and IGFBP-3 concentrations and provides clues to the potential role of the IGF axis in mediating effects of known (FOXO3 (show FOXO3 Antibodies)) and novel (ASXL2 (show ASXL2 Antibodies)) longevity-associated loci.
these findings suggest that IGFBP-3 suppresses transcription of EGR1 (show EGR1 Antibodies) and its target genes bFGF (show FGF2 Antibodies) and PDGF (show PDGFA Antibodies) through inhibiting IGF-1 (show IGF1 Antibodies)-dependent ERK (show EPHB2 Antibodies) and AKT (show AKT1 Antibodies) activation.
results indicate that hypoxia suppresses the osteogenic differentiation of mesenchymal stem cells via IGFBP3 up-regulation.
High Igfbp3 expression is associated with skin squamous cell carcinoma.
The study shows that the anti-tumoral effect of IGFBP-3 is due to inhibition of the Wnt (show WNT2 Antibodies) pathway and depends upon the presence of CD44 (show CD44 Antibodies), a receptor protein known to modulate Wnt (show WNT2 Antibodies) signaling.
IGFBP-3 influences severity of DSS (show PMP22 Antibodies)-induced colitis.
our studies found that the deletion of IGFBP3 results in behavioral impairments that are associated with abnormal synaptic function and monoaminergic neurotransmission, which helps to characterize the critical role of IGFBP3 in the brain
IGFBP-3 is an aggravating factor during hepatic ischemia-repefusion injury.
An increase in IGFBP-3 post-trauma may play an important role in limiting trauma-induced inflammatory and apoptotic pathways leading to retinal damage.
Even though knockout of IGFBP-3 is associated with only a subtle phenotype under control conditions, our results reveal that loss of this gene has measurable effects on breast carcinogenesis and breast cancer metastasis.
Igfbp3 is a marker for culture-activated hepatic stellate cells and plays a role in HSC (show FUT1 Antibodies) migration.
Igfbp2 (show IGFBP2 Antibodies)-5 are expressed in distinct and complementary patterns during cochlear development.
IGFBP-3 has novel protective effects on retinal and systemic vasculature and may be a therapeutic candidate for ocular complications such as diabetic retinopathy.
The study demonstrates that hyaluronan acts as an anti-inflammatory molecule by down-regulating IFNAR1 and IFNAR2, the signaling molecules STAT1, STAT2, JAK1 and the downstream apoptotic targets IGFBP3 and IFIT3.
These data suggest that endogenous IGFBP-3 plays a role in intrinsic apoptosis by facilitating phosphorylation and nuclear export of Nur77 (show NR4A1 Antibodies) to the cytoplasm where it exerts its apoptotic effect.
The present study suggests that the insulin (show INS Antibodies) like growth factor (IGF) system or imbalances between IGF and IGF binding (show HTRA1 Antibodies) proteins may be involved in cystic ovary disease of cattle.
spatial and temporal patterns of expression of IGFBP-2 (show IGFBP2 Antibodies) and -3 were markedly altered in the placentomes of nuclear transfer pregnancies
stimulation of IGFBP-3 mRNA levels by mitogens is regulated through both the PI3K and MAPK (show MAPK1 Antibodies) pathways in bovine mammary epithelial cells
Preincubation of erythroid cells with thrombospondin 1 (show THBS1 Antibodies) eliminated the inhibitory activity of IGFBP-3
GH, IGF-I (show IGF1 Antibodies) and IGF-IBP3 regulated the growth and development traits in different growth period.
delivery of insulin-like growth factor-1 (IGF-1 (show IGF1 Antibodies), delivered at concentrations of 0, 10, 50, and 100 ng/mL) affects the endogenous expression of IGF-1 (show IGF1 Antibodies), its receptor (IGF-1R (show IGF1R Antibodies)), and a well known IGF-1 (show IGF1 Antibodies) binding protein (IGFBP-3) by articular chondrocytes
Multivariable adjusted analyses did not reveal a statistically significant linear relationship between IGF1 (show IGF1 Antibodies) or IGFBP3 concentrations or their molar ratio and risk of myocardial infarction
Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells.
IGF-I (show IGF1 Antibodies), IGF-II, and IGFBP-3 mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
Increased oxidative stress from high glucose enhances IGFBP-3 expression, inducing apoptosis
Even though LRP-1 (show LRP1 Antibodies) mRNA and protein levels were dramatically reduced in LRP-1 (show LRP1 Antibodies)-silenced L6 cells compared with mock-silenced controls, rpIGFPB-3 suppressed proliferation rate to the same extent in both LRP-1 (show LRP1 Antibodies)-silenced and mock-silenced cultures.
cloning and sequencing; regulation of IGFBP-3 transcription by FSH (show BRD2 Antibodies) suggests a role for IGFBP-3 in follicular development that may be independent of IGF-I (show IGF1 Antibodies)
Follicle-stimulating hormone stimulation of IGFBP-3 transcription is mediated by cAMP via the PKA pathway and requires the P1-3 kinase and likely the MAPK (show MAPK1 Antibodies) pathways.
TAF4b may thus be the TFIID (show TBP Antibodies) component that binds to the TBP (show TBP Antibodies) site on the IGFBP-3 promoter and is essential for FSH (show BRD2 Antibodies) induction of IGFBP-3.
The results suggest that the expression of IGF2 and IGFBP3 mRNA in the adipose tissue of pigs exhibits specific developmental changes and different patterns between the two pig breeds.
allelic frequency of TAT (show C6orf134 Antibodies) in Chinese breeds was over 50%; allelic frequency of GGC (show GGCT Antibodies) was over 50% in all European breeds. TAT/TAT (show C6orf134 Antibodies) pigs scored higher in meat color than GGC/GGC (show GGCT Antibodies) pigs. results implied that IGFBP-3 may affect meat quality & carcass traits.
Data suggest that metabolism of IGFBP3, IGF1 (insulin-like growth factor I), and IGF2 (insulin-like growth factor II) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
insulin-like growth factor-binding protein 3
, insulin-like growth factor binding protein 3
, IGF-binding protein 3
, acid stable subunit of the 140 K IGF complex
, binding protein 29
, binding protein 53
, growth hormone-dependent binding protein
, insulin-like growth factor binding protein-3
, insulin-like growth factor-binding protein (IGF-BP3)