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anti-Human IGFBP3 Antibodies:
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Human Monoclonal IGFBP3 Primary Antibody for IF, WB - ABIN968565
Campbell, Durham, Hayes, Suwanichkul, Powell: Insulin-like growth factor-binding protein-3 binds fibrinogen and fibrin. in The Journal of biological chemistry 1999
Show all 5 references for ABIN968565
Human Polyclonal IGFBP3 Primary Antibody for EIA, IHC (p) - ABIN359863
Novosyadlyy, Dargel, Scharf: Expression of insulin-like growth factor-I and insulin-like growth factor binding proteins during thioacetamide-induced liver cirrhosis in rats. in Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2005
Show all 2 references for ABIN359863
Human Polyclonal IGFBP3 Primary Antibody for EIA, IHC (p) - ABIN359861
Muzumdar, Ma, Fishman, Yang, Atzmon, Vuguin, Einstein, Hwang, Cohen, Barzilai: Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin action. in Diabetes 2006
Show all 2 references for ABIN359861
Human Polyclonal IGFBP3 Primary Antibody for IF (p), IHC (p) - ABIN686497
Yuan, Han, Cong, Ge, Ma, Dai, Li, Bi: Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity. in International journal of nanomedicine 2014
Human Polyclonal IGFBP3 Primary Antibody for ELISA, WB - ABIN238551
Lin, Manson, Lee, Cook, Buring, Zhang: Intakes of calcium and vitamin D and breast cancer risk in women. in Archives of internal medicine 2007
insulin-like growth factor binding protein 3 exerts its ligand-independent action by antagonizing bone morphogenetic protein 2 (show BMP4 Antibodies) in zebrafish embryos
IGFBP-3 plays an important role in regulating pharyngeal cartilage and inner ear development and growth in zebrafish.
The stratification of individuals by gender revealed that Slovak males carrying IGFBP-3 G alleles (G32G or GG) had marginally increased risk for developing MDD as compared to CC homozygous males (p=0.09). In women, inverse association was observed between SNP rs1042522 and MDD risk (p=0.04 for recessive model).
this study identified several loci associated with circulating IGF-I (show IGF1 Antibodies) and IGFBP-3 concentrations and provides clues to the potential role of the IGF axis in mediating effects of known (FOXO3 (show FOXO3 Antibodies)) and novel (ASXL2 (show ASXL2 Antibodies)) longevity-associated loci.
these findings suggest that IGFBP-3 suppresses transcription of EGR1 (show EGR1 Antibodies) and its target genes bFGF (show FGF2 Antibodies) and PDGF (show PDGFA Antibodies) through inhibiting IGF-1 (show IGF1 Antibodies)-dependent ERK (show EPHB2 Antibodies) and AKT (show AKT1 Antibodies) activation.
results indicate that hypoxia suppresses the osteogenic differentiation of mesenchymal stem cells via IGFBP3 up-regulation.
Data suggest that serum levels IGF-I (insulin-like growth factor I (show IGF1 Antibodies)) and IGFBP-3 (insulin-like growth factor binding protein 3) in pediatric patients with osteogenesis imperfecta (show COL1A2 Antibodies) (OI) and short statue are not different according to severity of OI or type of OI (patients with types 3 and 4 were investigated here); all patients had been treated with intravenous neridronate every 3 months for at least 2 years.
Meta-analysis suggests that for esophageal cancer, the low IGFBP-3 level is associated with high cancer risk, poor prognosis, and unfavorable tumor stage and metastasis. [meta-analysis]
Expression of IL-24 (show IL24 Antibodies) and IGFBP-3 significantly suppressed prostate cancer tumor growth in vivo.
Blood IGFBP3 was lower in Black participants compared to Whites.
The microRNA-125b level promotes invasive ability in p53 (show TP53 Antibodies)-mutated cells via PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) activation by targeting of insulin-like growth factor-binding protein-3.
Increased IGF-1 (show IGF1 Antibodies) or IGFBP-3 in subcutaneous adipose tissue of acromegaly do not appear to contribute to systemic differences in insulin (show INS Antibodies) sensitivity.
our studies found that the deletion of IGFBP3 results in behavioral impairments that are associated with abnormal synaptic function and monoaminergic neurotransmission, which helps to characterize the critical role of IGFBP3 in the brain
IGFBP-3 is an aggravating factor during hepatic ischemia-repefusion injury.
An increase in IGFBP-3 post-trauma may play an important role in limiting trauma-induced inflammatory and apoptotic pathways leading to retinal damage.
Even though knockout of IGFBP-3 is associated with only a subtle phenotype under control conditions, our results reveal that loss of this gene has measurable effects on breast carcinogenesis and breast cancer metastasis.
Igfbp3 is a marker for culture-activated hepatic stellate cells and plays a role in HSC (show FUT1 Antibodies) migration.
Igfbp2 (show IGFBP2 Antibodies)-5 are expressed in distinct and complementary patterns during cochlear development.
IGFBP-3 has novel protective effects on retinal and systemic vasculature and may be a therapeutic candidate for ocular complications such as diabetic retinopathy.
IGFBP-3 activates inhibitory Smad (show SMAD1 Antibodies) signaling in 3T3-L1 cells and that endogenous IGFBP-3 modulates their adipogenic differentiation by regulating cell sensitivity towards the inhibitory effect of TGFbeta (show TGFB1 Antibodies).
Wnt (show WNT2 Antibodies) signaling exerts an antiproliferative effect on adult cardiac progenitor cells through IGFBP3.
IGFBP-3 positively and negatively impacts on IGF1 (show IGF1 Antibodies)-induced lung cancer development.
These data suggest that endogenous IGFBP-3 plays a role in intrinsic apoptosis by facilitating phosphorylation and nuclear export of Nur77 (show NR4A1 Antibodies) to the cytoplasm where it exerts its apoptotic effect.
The present study suggests that the insulin (show INS Antibodies) like growth factor (IGF) system or imbalances between IGF and IGF binding (show HTRA1 Antibodies) proteins may be involved in cystic ovary disease of cattle.
spatial and temporal patterns of expression of IGFBP-2 (show IGFBP2 Antibodies) and -3 were markedly altered in the placentomes of nuclear transfer pregnancies
stimulation of IGFBP-3 mRNA levels by mitogens is regulated through both the PI3K and MAPK (show MAPK1 Antibodies) pathways in bovine mammary epithelial cells
Preincubation of erythroid cells with thrombospondin 1 (show THBS1 Antibodies) eliminated the inhibitory activity of IGFBP-3
GH, IGF-I (show IGF1 Antibodies) and IGF-IBP3 regulated the growth and development traits in different growth period.
delivery of insulin-like growth factor-1 (IGF-1 (show IGF1 Antibodies), delivered at concentrations of 0, 10, 50, and 100 ng/mL) affects the endogenous expression of IGF-1 (show IGF1 Antibodies), its receptor (IGF-1R (show IGF1R Antibodies)), and a well known IGF-1 (show IGF1 Antibodies) binding protein (IGFBP-3) by articular chondrocytes
Multivariable adjusted analyses did not reveal a statistically significant linear relationship between IGF1 (show IGF1 Antibodies) or IGFBP3 concentrations or their molar ratio and risk of myocardial infarction
Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells.
IGF-I (show IGF1 Antibodies), IGF-II, and IGFBP-3 mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
Increased oxidative stress from high glucose enhances IGFBP-3 expression, inducing apoptosis
Even though LRP-1 (show LRP1 Antibodies) mRNA and protein levels were dramatically reduced in LRP-1 (show LRP1 Antibodies)-silenced L6 cells compared with mock-silenced controls, rpIGFPB-3 suppressed proliferation rate to the same extent in both LRP-1 (show LRP1 Antibodies)-silenced and mock-silenced cultures.
cloning and sequencing; regulation of IGFBP-3 transcription by FSH (show BRD2 Antibodies) suggests a role for IGFBP-3 in follicular development that may be independent of IGF-I (show IGF1 Antibodies)
Follicle-stimulating hormone stimulation of IGFBP-3 transcription is mediated by cAMP via the PKA pathway and requires the P1-3 kinase and likely the MAPK (show MAPK1 Antibodies) pathways.
TAF4b may thus be the TFIID (show TBP Antibodies) component that binds to the TBP (show TBP Antibodies) site on the IGFBP-3 promoter and is essential for FSH (show BRD2 Antibodies) induction of IGFBP-3.
The results suggest that the expression of IGF2 and IGFBP3 mRNA in the adipose tissue of pigs exhibits specific developmental changes and different patterns between the two pig breeds.
allelic frequency of TAT (show C6orf134 Antibodies) in Chinese breeds was over 50%; allelic frequency of GGC (show GGCT Antibodies) was over 50% in all European breeds. TAT/TAT (show C6orf134 Antibodies) pigs scored higher in meat color than GGC/GGC (show GGCT Antibodies) pigs. results implied that IGFBP-3 may affect meat quality & carcass traits.
Data suggest that metabolism of IGFBP3, IGF1 (insulin-like growth factor I), and IGF2 (insulin-like growth factor II) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
insulin-like growth factor-binding protein 3
, insulin-like growth factor binding protein 3
, IGF-binding protein 3
, acid stable subunit of the 140 K IGF complex
, binding protein 29
, binding protein 53
, growth hormone-dependent binding protein
, insulin-like growth factor binding protein-3
, insulin-like growth factor-binding protein (IGF-BP3)